Nicotinamide phosphoribosyltransferase

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Extracellular NAMPT

Adipocytes Adipose tissue Cytokine Dimer Monomer

14 related topics

Expression and regulation

SIRT1 Endurance-trained Expression Type 2 diabetic Aerobic

9 related topics

As a drug target

Glycolysis Melanoma Cutaneous T-cell lymphoma Leukemia Epithelial–mesenchymal transition

9 related topics

Function

Sirtuins PARPs CD38 De novo synthesis Tryptophan

7 related topics

Key facts & relationships

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2.4.2.12: ↗
Aliases: NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS,…
Band: 7q22.3 · 12|12 A3
Bgee: blood · pericardium · gastric mucosa · right lung · vena cava
BioGPS: More reference expression data

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Overview

Function

Sirtuins Sirtuin
PARPs Poly ADP ribose polymerase
CD38
De novo synthesis
Tryptophan
PPi Pyrophosphate
Glycosyltransferase

Expression and regulation

SIRT1 Sirtuin 1
Endurance-trained Endurance training
Expression Gene expression
Type 2 diabetic Type 2 diabetes
Aerobic Aerobic exercise
Resistance Strength training
Proinflammatory
Macrophages Macrophage
Astrocytes Astrocyte

Extracellular NAMPT

Adipocytes Adipocyte
Adipose tissue
Cytokine
Dimer Dimer (chemistry)
Monomer
B cell
Interleukin-7
Stem cell factor
Pancreatic Pancreas
Beta cells Beta cell
Neurons Neuron
Insulin
Osaka University Medical School Osaka University Medical School?action=edit&redlink=1
Committee for Research Integrity Committee for Research Integrity?action=edit&redlink=1

As a drug target

Ligands

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Nicotinamide phosphoribosyltransferase

Nodes64

Edges63

Triples134

Avg. degree1.97

Density0.03125

Components1

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Nicotinamide phosphoribosyltransferase

Top relations

Gene ontology · 45

Nicotinamide phosphoribosyltransferase → adipose tissue development, ageing, catalytic activity, cell junction, cell-cell signaling, cellular response to amyloid-beta, cellular response to ionizing radiation, cellular response to oxygen-glucose deprivation, circadian regulation of gene expression, circadian rhythm, cytokine activity, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, female pregnancy, glycosyltransferase activity, identical protein binding, insulin receptor signaling pathway

Bgee · 20

Nicotinamide phosphoribosyltransferase → blood, decidua, digastric muscle, gallbladder, gastric mucosa, gastrula, interventricular septum, iris, left uterine tube, lower lobe of lung, myocardium of ventricle, pericardium, right lung, sternocleidomastoid muscle, tail of epididymis, temporal muscle, triceps brachii muscle, upper lobe of left lung, vastus lateralis muscle, vena cava

RNA expression pattern · 20

related to External links · 13

Nicotinamide phosphoribosyltransferase → Human Nicotinamide, Medicine Medical Subject Headings, MeSH, Mouse Nicotinamide, NAMPT, National Library, Overview, P43490, PDB, PDBe-KB, Q99KQ4, UCSC Genome Browser, UniProt

related to Function · 11

Nicotinamide phosphoribosyltransferase → CD38, De, NAD, NAM, Nicotinamide, NMN, PARPs, PPi, The, This, Thus

Band · 2

Nicotinamide phosphoribosyltransferase → 12|12 A3, 7q22.3

Chr. · 2

Nicotinamide phosphoribosyltransferase → Chromosome 12 (mouse), Chromosome 7 (human)

End · 2

Nicotinamide phosphoribosyltransferase → 106,285,966 bp, 32,903,348 bp

2.4.2.12 · 1

Nicotinamide phosphoribosyltransferase → ↗

Aliases · 1

Nicotinamide phosphoribosyltransferase → NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase

Important terminology Word statistics

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Important terminology

nampt inampt nicotinamide nad enampt visfatin enzyme gene pbef human phosphoribosyltransferase bp activity cytokine chr band mouse extracellular reported nmn

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Nicotinamide phosphoribosyltransferase	2.4.2.12	↗	1.00	infobox
Nicotinamide phosphoribosyltransferase	Aliases	NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase	1.00	infobox
Nicotinamide phosphoribosyltransferase	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS,…	1.00	infobox
Nicotinamide phosphoribosyltransferase	Band	7q22.3	1.00	infobox
Nicotinamide phosphoribosyltransferase	Band	12\|12 A3	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	blood	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	pericardium	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	gastric mucosa	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	right lung	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	vena cava	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	upper lobe of left lung	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	left uterine tube	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	tail of epididymis	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	lower lobe of lung	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	gallbladder	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	gastrula	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	decidua	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	temporal muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	triceps brachii muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	iris	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	sternocleidomastoid muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	digastric muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	vastus lateralis muscle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	myocardium of ventricle	1.00	infobox
Nicotinamide phosphoribosyltransferase	Bgee	interventricular septum	1.00	infobox
Nicotinamide phosphoribosyltransferase	BioGPS	More reference expression data	1.00	infobox
Nicotinamide phosphoribosyltransferase	Chr.	Chromosome 7 (human)	1.00	infobox
Nicotinamide phosphoribosyltransferase	Chr.	Chromosome 12 (mouse)	1.00	infobox
Nicotinamide phosphoribosyltransferase	Databases	NCBI: entry; OMA: entry	1.00	infobox
Nicotinamide phosphoribosyltransferase	End	106,285,966 bp	1.00	infobox

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