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Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein…

Art, Some roles of caspases & Overview

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Key facts & relationships

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AlphaFold
IPR002398 · PF00656
Available protein structures:
IPR002398 · PF00656
InterPro
IPR002398
MEROPS
C14
PDB
IPR002398 PF00656 (ECOD; PDBsum)
Pfam
PF00656

Topics to explore

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Overview

Activation of caspases

Some roles of caspases

Discovery of caspases

Detection

Advanced semantic analysis

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Map overview Semantic statistics

Caspase

Nodes79
Edges78
Triples131
Avg. degree1.97
Density0.025316
Components1

How this topic connects Entity context

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Caspase

Top relations

related to External links · 18
Caspase → Accessed, Apoptosis, Apoptosis Archived, Beaker Blog, Eukaryotic Linear Motif, FAS, March, Medicine Medical Subject Headings, MeSH, National Library, Pages, PMAP-animationCaspases, Simple, The Mechanisms, TNF, Tumors Beware, Video Demonstrates, Wayback Machine Kimball's Biology
related to Discovery of caspases · 13
Caspase → At, Caspases, CPP32, Drosophila, For, Horvitz, ICE, In, Junying Yuan, Other, Researchers, Robert Horvitz, Yama
related to Detection · 12
Caspase → AFC, AMC, Asp, Aspartic, Chromogenic, Detection, DEVD, Glu, Glutamic, In, Val, Valine
related to Functional classification of caspases · 9
Caspase → Caspase-14, Executioner, Inflammatory, Initiator, Most, Note, The, These, UVB
related to Pyroptosis · 7
Caspase → Caspase-1, Caspase-11, Caspase-4, Caspase-5, It, Pyroptosis, This
related to Apoptosis · 6
Caspase → Additionally, Apoptosis, Apoptotic, DNA, The, This
related to Cleavage · 6
Caspase → Caspases, Cleavage, Executioner, Initiator, Once, This
related to Role in inflammation · 6
Caspase → Caspase-1, Caspase-11, Caspase-4, Caspase-5, Inflammation, Inflammatory Caspases
related to Dimerisation · 5
Caspase → CARD, DED, Multiprotein, Some, The
related to Activation of caspases · 4
Caspase → Activation, Caspases, The, This

Important terminology Word statistics

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Important terminology

caspases cell death apoptosis activation caspase-1 programmed cellular role identified form cells pyroptosis inflammatory also called cleavage roles protein initiator

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CaspaseAlphaFoldIPR0023981.00infobox
CaspaseAlphaFoldPF006561.00infobox
CaspaseAvailable protein structures:IPR0023981.00infobox
CaspaseAvailable protein structures:PF006561.00infobox
CaspaseInterProIPR0023981.00infobox
CaspaseMEROPSC141.00infobox
CaspasePDBIPR002398 PF00656 (ECOD; PDBsum)1.00infobox
CaspasePfamPF006561.00infobox
CaspasePfam clanCL00931.00infobox
CaspasePROSITEPS502081.00infobox
CaspaseSCOP21ice / SCOPe / SUPFAM1.00infobox
CaspaseSymbolPeptidase_C141.00infobox

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    Min side: 3
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