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PTPRK: Function, Interactions & Structure

Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene. PTPRK is also known as PTPkappa and PTPκ.

Language: English [EN]
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PTPRK topic overview

The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around PTPRK.

Related topics
25
Source areas
6
Connected nodes
31
Extracted relationships
138
Concept neighborhoods
10
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 8 topics
Interactions · 7 topics
Regulation · 3 topics
Structure · 3 topics
Clinical significance · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.3.48
Aliases
PTPRK, R-PTP-kappa, protein tyrosine phosphatase, receptor type K, protein tyrosine phosphatase receptor type K
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2C7S
Band
6q22.33 · 10 A4|10 15.06 cM
Bgee
corpus callosum · epithelium of colon · gallbladder · duodenum · Achilles tendon
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

  • RPTPM PTPmu?action=edit&redlink=1
  • RPTPT PTPrho?action=edit&redlink=1
  • RPTPU PCP-2

Regulation

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PTPRK connects Entity context

The extracted context around PTPRK shows recurring relationship patterns in the source. For example, PTPRK → adherens junction, axon, beta-catenin binding, cell adhesion, cell junction, cell migration, cell surface, cell-cell junction, cellular response to reactive oxygen species, cellular response to UV, dendrite, dephosphorylation, focal adhesion assembly, gamma-catenin binding, hydrolase activity, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, leading edge membrane, membrane Another extracted example is PTPRK → Achilles tendon, barrel cortex, ciliary body, corpus callosum, duodenum, epithelium of colon, epithelium of lens, gallbladder, genital tubercle, iris, islet of Langerhans, Paneth cell, rectum, Region I of hippocampus proper, right kidney, stomach, stromal cell of endometrium, superior frontal gyrus, tail of embryo, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

PTPRK

Top relations

Gene ontology · 40
PTPRK → adherens junction, axon, beta-catenin binding, cell adhesion, cell junction, cell migration, cell surface, cell-cell junction, cellular response to reactive oxygen species, cellular response to UV, dendrite, dephosphorylation, focal adhesion assembly, gamma-catenin binding, hydrolase activity, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, leading edge membrane, membrane
Bgee · 20
PTPRK → Achilles tendon, barrel cortex, ciliary body, corpus callosum, duodenum, epithelium of colon, epithelium of lens, gallbladder, genital tubercle, iris, islet of Langerhans, Paneth cell, rectum, Region I of hippocampus proper, right kidney, stomach, stromal cell of endometrium, superior frontal gyrus, tail of embryo, vestibular membrane of cochlear duct
RNA expression pattern · 20
PTPRK → Achilles tendon, barrel cortex, ciliary body, corpus callosum, duodenum, epithelium of colon, epithelium of lens, gallbladder, genital tubercle, iris, islet of Langerhans, Paneth cell, rectum, Region I of hippocampus proper, right kidney, stomach, stromal cell of endometrium, superior frontal gyrus, tail of embryo, vestibular membrane of cochlear duct
related to Glioma · 7
PTPRK → Assem, Expression, In, LOH, PTPkappa, U251-MG, U87-MG
related to Interactions · 7
PTPRK → Beta-catenin, CDH-1, E-cadherin, EGFR, Epidermal, HER2, Plakoglobin
related to Expression · 5
PTPRK → HaCaT, HER2, PTPkappa, Stimulation, TGFβ1
related to Function · 5
PTPRK → Protein, PTP, PTPs, The, Tyrosine
related to Alternative splicing · 3
PTPRK → Alternative, PTPkappa, Two
Band · 2
PTPRK → 10 A4|10 15.06 cM, 6q22.33
Chr. · 2
PTPRK → Chromosome 10 (mouse), Chromosome 6 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ptpkappa cells cell gene expression phosphatase activity tyrosine human protein observed also development egfr proliferation mrna tumor shown bp membrane

PTPRK relationships Subject–Predicate–Object triples

TTTA extracted 138 structured relationships around PTPRK. Examples in this analysis include PTPRK → 3.1.3.48 → ↗ and PTPRK → Aliases → PTPRK, R-PTP-kappa, protein tyrosine phosphatase, receptor type K, protein tyrosine phosphatase receptor type K. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PTPRK3.1.3.481.00infobox
PTPRKAliasesPTPRK, R-PTP-kappa, protein tyrosine phosphatase, receptor type K, protein tyrosine phosphatase receptor type K1.00infobox
PTPRKAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2C7S1.00infobox
PTPRKBand6q22.331.00infobox
PTPRKBand10 A4|10 15.06 cM1.00infobox
PTPRKBgeecorpus callosum1.00infobox
PTPRKBgeeepithelium of colon1.00infobox
PTPRKBgeegallbladder1.00infobox
PTPRKBgeeduodenum1.00infobox
PTPRKBgeeAchilles tendon1.00infobox
PTPRKBgeesuperior frontal gyrus1.00infobox
PTPRKBgeeislet of Langerhans1.00infobox
PTPRKBgeerectum1.00infobox
PTPRKBgeestromal cell of endometrium1.00infobox
PTPRKBgeestomach1.00infobox
PTPRKBgeetail of embryo1.00infobox
PTPRKBgeegenital tubercle1.00infobox
PTPRKBgeebarrel cortex1.00infobox
PTPRKBgeePaneth cell1.00infobox
PTPRKBgeeciliary body1.00infobox
PTPRKBgeeright kidney1.00infobox
PTPRKBgeeiris1.00infobox
PTPRKBgeeRegion I of hippocampus proper1.00infobox
PTPRKBgeeepithelium of lens1.00infobox
PTPRKBgeevestibular membrane of cochlear duct1.00infobox
PTPRKBioGPSMore reference expression data1.00infobox
PTPRKChr.Chromosome 6 (human)1.00infobox
PTPRKChr.Chromosome 10 (mouse)1.00infobox
PTPRKDatabasesNCBI: entry; OMA: entry1.00infobox
PTPRKEnd128,520,616 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PTPRK bring nearby vocabulary together. In this analysis, examples include Observed, Cell and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Chromosome
    • Β-gal
    • Ptprk
    • Suppressor
    • Activity
    • Tumor
    • Human
    • Bp
    • Chr
    • Phosphatase
    • Mouse
    • Expression
  • protein tyrosine phosphatase
    • Activity
    • Tyrosine
    • Domain
    • Mouse
    • Binding
    • Mrna
    • Ptprk
    • Gene
    • Ptpkappa
    • Expression
    • Development
    • Egfr
  • tumor suppressor gene
    • Tumor
    • Chromosome
    • Β-gal
    • Ptprk
    • Suppressor
    • Activity
    • Human
    • Bp
    • Chr
    • Phosphatase
    • Mouse
    • Expression
  • function
    • Bp
    • Chr
    • Chromosome
    • Growth
    • Suppressor
    • Melanoma
    • Migration
    • Proliferation
    • Tumor
    • Tyrosine
    • Human
    • Protein
  • PTPRK
    • Observed
    • Cell
    • Growth
    • Mrna
    • Shown
    • Tumor
    • Mouse
    • Suppressor
    • Domain
    • Membrane
    • Migration
    • Tyrosine
  • ptprk
    • Observed
    • Cell
    • Growth
    • Mrna
    • Shown
    • Tumor
    • Mouse
    • Suppressor
    • Domain
    • Membrane
    • Migration
    • Tyrosine
  • type i transmembrane protein
    • Mouse
    • Mrna
    • Tyrosine
    • Increased
    • Membrane
    • Proliferation
    • Ptpkappa
    • Cell
    • Band
    • Ptprk
    • Β-gal
    • Full-length
  • epidermal growth factor receptor
    • Migration
    • Mrna
    • Human
    • Ptprk
    • Increased
    • Mouse
    • Suppressor
    • Membrane
    • Proliferation
    • Shown
    • Tumor
    • Tyrosine

Connections between topic areas Semantic bridges

For PTPRK, one of the stronger structural bridges in this analysis connects PTPRK with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PTPRKFunction · splits 23 ⟂ 9
PTPRKInteractions · splits 24 ⟂ 8
PTPRKStructure · splits 28 ⟂ 4
PTPRKRegulation · splits 28 ⟂ 4
PTPRKOverview · splits 29 ⟂ 3
PTPRKClinical significance · splits 29 ⟂ 3

Map overview Semantic statistics

PTPRK

Nodes32
Edges31
Triples138
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around PTPRK to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PTPRK · EN edition · Analysis: TopicsToTalkAbout

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