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Gap junction

Gap junctions are membrane channels between adjacent cells that allow the direct exchange of cytoplasmic substances, such as small molecules, substrates, and metabolites. Gap junctions were first described as close appositions alongside tight junctions, but based on electron microscopy studies, they were later renamed gap junctions to distinguish them…

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FMA
67423
MeSH
D017629
TH
H1.00.01.1.02024

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Properties of connexon pairs

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Gap junction

Nodes111
Edges110
Triples93
Avg. degree1.98
Density0.018018
Components1

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Gap junction

Top relations

related to Occurrence and distribution · 14
Gap junction → Adult, An, Exceptions, Gap, However, Innexins, Of, Pannexins, Since, Sometimes, Techniques, The, Tissues, Trypanosomatidae
related to Levels of organization · 10
Gap junction → DNA, In, Molecules, One, Otherwise, RNA, Tens, The, Two, When
related to Embryonic, organ and tissue development · 8
Gap junction → Conversely, Embryos, Gap, In, It, Refinement, The, While
related to Hemichannel function · 8
Gap junction → At, E2, Hemichannels, In, Nicotinamide, On, This, With
related to Form to function · 7
Gap junction → Gap, Implicit, Later, The, This, Well, When
related to Functions · 7
Gap junction → Adhesive, At, Cx32, Cx36, Cx43, Electrical, Role
related to Properties of connexon pairs · 6
Gap junction → Allows, Ca2, Ensures, Generally, IP, Large
related to Properties of connexons as hemichannels · 6
Gap junction → It, Mechanical, Pore, Some, They, Unpaired
related to Structure · 5
Gap junction → Hetero-hexamers, In, Innexins, Invertebrate, Though
related to Electrical and chemical synapses · 4
Gap junction → Another, Because, By, The

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Important terminology

gap junction junctions connexins cells proteins connexin plaques cell form electrical plaque connexons protein hemichannels connexon membrane channels also intercellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Gap junctionFMA674231.00infobox
Gap junctionMeSHD0176291.00infobox
Gap junctionTHH1.00.01.1.020241.00infobox
confocal microscopy allow more rapid surveys of large areas of tissueinstance ofTechniques0.80text
in bone were shown to have cells that were still connected with gap junctionsinstance ofTissues that were traditionally considered to have isolated cells0.80text
however tenuouslyinstance ofTissues that were traditionally considered to have isolated cells0.80text
cancers or the aging process.Since the discovery of innexinsinstance ofSometimes the number of gap junctions are reduced or absent in diseased tissues0.80text
pannexinsinstance ofSometimes the number of gap junctions are reduced or absent in diseased tissues0.80text
unnexinsinstance ofSometimes the number of gap junctions are reduced or absent in diseased tissues0.80text
gaps in our knowledge of intercellular communication are becoming more definedinstance ofSometimes the number of gap junctions are reduced or absent in diseased tissues0.80text
secondary messengersinstance ofwhich facilitates the transfer of small molecules0.80text
metabolitesinstance ofwhich facilitates the transfer of small molecules0.80text

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