Cadherin-2

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Function

Neural tissue Neurons Metastasis Transmembrane Glycoprotein

41 related topics

Interactions

Interact CDH11 CTNND1 CTNNA1 LRRC7

10 related topics

Structure

Amino acids Cadherin repeats Cytoplasmic Interact Anti-parallel conformation

5 related topics

Clinical significance

Corpus callosum Obsessive-compulsive disorder Tourette disorder Heart disease

4 related topics

Key facts & relationships

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Aliases: CDH2, CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NCG, 1NCH, 1NCI, 1NCJ, 1OP4, 2QVI, 3Q2W, 4NUM, 4NUP, 4NUQ
Band: 18q12.1 · 18 A1|18 10.1 cM
Bgee: right ventricle · ventricular zone · stromal cell of endometrium · myocardium · myocardium of left ventricle
BioGPS: More reference expression data
Chr.: Chromosome 18 (human) · Chromosome 18 (mouse)

Topics to explore

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Overview

Structure

Amino acids Amino acid
Cadherin repeats Cadherin
Cytoplasmic Cytoplasm
Interact Protein-protein interaction
Anti-parallel conformation Antiparallel (biochemistry)

Function

Neural tissue
Neurons Neuron
Metastasis
Transmembrane Transmembrane protein
Glycoprotein
Calcium-dependent cell adhesion molecule family Cell adhesion molecule
Extracellular domain Ectodomain
C-terminal C-terminus
Catenins Catenin
Actin
Cytoskeleton
Gastrulation
Left-right asymmetry Symmetry (biology)
Embryo
Implantation Implantation (embryology)
Mesoderm
Myofibrillogenesis Myocyte
Epithelial cells Epithelial cell
Trabecular Trabeculae
Myocardium
Endocardium
Desmosomes Desmosome
Gap junction
Sarcolemma
Ventricular Ventricle (heart)
Z-line Sarcomere
Connexin 43 GJA1
Ventricular tachycardia
Arrhythmias Heart arrhythmia
Ion channel

Clinical significance

Interactions

Interact Protein–protein interaction
CDH11
CTNND1
CTNNA1 Catenin (cadherin-associated protein), alpha 1
LRRC7
PTPRM
PTPRT
Plakoglobin
XIRP1 XIRP1?action=edit&redlink=1
SCARB2

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes76

Edges75

Triples180

Avg. degree1.97

Density0.026316

Components1

How this topic connects Entity context

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Cadherin-2

Top relations

Gene ontology · 75

Cadherin-2 → adherens junction, adherens junction organization, alpha-catenin binding, apical part of cell, apical plasma membrane, basolateral plasma membrane, beta-catenin binding, blood vessel morphogenesis, brain morphogenesis, cadherin binding, calcium ion binding, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, catenin complex, cell adhesion, cell junction, cell migration, cell morphogenesis, cell surface, cell-cell adhesion, cell-cell adhesion mediated by cadherin

Bgee · 20

Cadherin-2 → arcuate nucleus, atrium, Brodmann area 23, cardiac muscle tissue of left ventricle, cardiac muscle tissue of right atrium, dorsomedial hypothalamic nucleus, endothelial cell, ganglionic eminence, lateral geniculate nucleus, lateral septal nucleus, mammillary body, median eminence, middle temporal gyrus, myocardium, myocardium of left ventricle, myocardium of ventricle, right ventricle, stromal cell of endometrium, ventricular zone, ventromedial nucleus

RNA expression pattern · 20

related to Role in cardiac muscle · 14

Cadherin-2 → Cre N-cadherin, E-cadherin, Expression, Further, In, KCNE2, Kv1, Mice, Mouse, N-cadherin, These, Ventricular, Within, Z-line

related to Interactions · 11

Cadherin-2 → Beta-catenin, CDH11, CTNNA1, CTNND1, IIb RPTPs, LRRC7, PTPmu, PTPrho, PTPRM, PTPRT, XIRP1SCARB2

related to Role in neurons · 6

Cadherin-2 → Cadherin-catenin, For, In, Loss, N-cadherin, N-cadherins

is a · 4

Cadherin-2 → essential component in adherens junctions, integral component in adherens junctions residing at intercalated discs, transmembrane, transmembrane protein expressed in multiple tissues and functions to mediate cell

related to Function · 3

Cadherin-2 → C-terminal, Neural, These

related to Role in cancer metastasis · 3

Cadherin-2 → E-cadherins, This, When

Band · 2

Cadherin-2 → 18 A1|18 10.1 cM, 18q12.1

Important terminology Word statistics

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Important terminology

cdh2 cell human adhesion protein cardiac function also expression bp gene cells intercalated muscle cadherin chr band n-cadherin development adjacent

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Cadherin-2	Aliases	CDH2, CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14	1.00	infobox
Cadherin-2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NCG, 1NCH, 1NCI, 1NCJ, 1OP4, 2QVI, 3Q2W, 4NUM, 4NUP, 4NUQ	1.00	infobox
Cadherin-2	Band	18q12.1	1.00	infobox
Cadherin-2	Band	18 A1\|18 10.1 cM	1.00	infobox
Cadherin-2	Bgee	right ventricle	1.00	infobox
Cadherin-2	Bgee	ventricular zone	1.00	infobox
Cadherin-2	Bgee	stromal cell of endometrium	1.00	infobox
Cadherin-2	Bgee	myocardium	1.00	infobox
Cadherin-2	Bgee	myocardium of left ventricle	1.00	infobox
Cadherin-2	Bgee	endothelial cell	1.00	infobox
Cadherin-2	Bgee	ganglionic eminence	1.00	infobox
Cadherin-2	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
Cadherin-2	Bgee	Brodmann area 23	1.00	infobox
Cadherin-2	Bgee	middle temporal gyrus	1.00	infobox
Cadherin-2	Bgee	median eminence	1.00	infobox
Cadherin-2	Bgee	atrium	1.00	infobox
Cadherin-2	Bgee	lateral septal nucleus	1.00	infobox
Cadherin-2	Bgee	myocardium of ventricle	1.00	infobox
Cadherin-2	Bgee	ventromedial nucleus	1.00	infobox
Cadherin-2	Bgee	lateral geniculate nucleus	1.00	infobox
Cadherin-2	Bgee	cardiac muscle tissue of left ventricle	1.00	infobox
Cadherin-2	Bgee	dorsomedial hypothalamic nucleus	1.00	infobox
Cadherin-2	Bgee	mammillary body	1.00	infobox
Cadherin-2	Bgee	arcuate nucleus	1.00	infobox
Cadherin-2	BioGPS	More reference expression data	1.00	infobox
Cadherin-2	Chr.	Chromosome 18 (human)	1.00	infobox
Cadherin-2	Chr.	Chromosome 18 (mouse)	1.00	infobox
Cadherin-2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Cadherin-2	End	28,177,946 bp	1.00	infobox
Cadherin-2	End	16,942,303 bp	1.00	infobox

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