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Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency…
The analysis highlights Standards, Overview and Derivatives as prominent areas in the source structure around Wortmannin.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around Wortmannin shows recurring relationship patterns in the source. For example, Wortmannin → Inhibiting PI3K, Phosphoinositide-3-kinase, PI3K, PTEN Another extracted example is Wortmannin → commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, PI3K inhibitor. Use these groups to spot repeated connection types before inspecting the individual relationships.
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pi3k phase inhibitor sonolisib inhibit cell vitro ic50 commonly used also 10 ii references signaling trial mw-parser-output solid media screen
TTTA extracted 11 structured relationships around Wortmannin. Examples in this analysis include Wortmannin → is a → commonly used cell biology reagent that has been used previously in research to inhibit DNA repair and Wortmannin → is a → PI3K inhibitor. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Wortmannin | is a | commonly used cell biology reagent that has been used previously in research to inhibit DNA repair | 0.90 | text |
| Wortmannin | is a | PI3K inhibitor | 0.90 | text |
| mTOR | instance of | and III PI3K members although it can also inhibit other PI3K-related enzymes | 0.80 | text |
| DNA-PKcs | instance of | and III PI3K members although it can also inhibit other PI3K-related enzymes | 0.80 | text |
| some phosphatidylinositol 4-kinases | instance of | and III PI3K members although it can also inhibit other PI3K-related enzymes | 0.80 | text |
| myosin light chain kinase | instance of | and III PI3K members although it can also inhibit other PI3K-related enzymes | 0.80 | text |
| Wortmannin | related to Derivatives | Medicinal | 0.60 | section |
| Wortmannin | related to Phosphoinositide-3-kinase | Phosphoinositide-3-kinase | 0.60 | section |
| Wortmannin | related to Phosphoinositide-3-kinase | PI3K | 0.60 | section |
| Wortmannin | related to Phosphoinositide-3-kinase | PTEN | 0.60 | section |
| Wortmannin | related to Phosphoinositide-3-kinase | Inhibiting PI3K | 0.60 | section |
The concept neighborhoods around Wortmannin bring nearby vocabulary together. In this analysis, examples include Also, Dark and Derivatives. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Wortmannin, one of the stronger structural bridges in this analysis connects Wortmannin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Wortmannin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Overview & Derivatives, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Wortmannin · EN edition · Analysis: TopicsToTalkAbout