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Wortmannin: Standards, Overview & Derivatives

Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency…

Language: English [EN]
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Wortmannin topic overview

The analysis highlights Standards, Overview and Derivatives as prominent areas in the source structure around Wortmannin.

Related topics
24
Source areas
2
Connected nodes
26
Extracted relationships
15
Concept neighborhoods
16
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 19 topics
Derivatives · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Derivatives

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Wortmannin connects Entity context

The extracted context around Wortmannin shows recurring relationship patterns in the source. For example, Wortmannin → Media, PDB, Wikimedia Commons Wortmannin, Wiktionary-logo-en-v2 Another extracted example is Wortmannin → Inhibiting PI3K, Phosphoinositide-3-kinase, PI3K, PTEN. Use these groups to spot repeated connection types before inspecting the individual relationships.

Wortmannin

Top relations

related to External links · 4
Wortmannin → Media, PDB, Wikimedia Commons Wortmannin, Wiktionary-logo-en-v2
related to Phosphoinositide-3-kinase · 4
Wortmannin → Inhibiting PI3K, Phosphoinositide-3-kinase, PI3K, PTEN
is a · 2
Wortmannin → commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, PI3K inhibitor
related to Derivatives · 1
Wortmannin → Medicinal

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pi3k phase inhibitor sonolisib inhibit cell vitro ic50 commonly used also 10 ii references signaling trial mw-parser-output solid media screen

Wortmannin relationships Subject–Predicate–Object triples

TTTA extracted 15 structured relationships around Wortmannin. Examples in this analysis include Wortmannin → is a → commonly used cell biology reagent that has been used previously in research to inhibit DNA repair and Wortmannin → is a → PI3K inhibitor. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Wortmanninis acommonly used cell biology reagent that has been used previously in research to inhibit DNA repair0.90text
Wortmanninis aPI3K inhibitor0.90text
mTORinstance ofand III PI3K members although it can also inhibit other PI3K-related enzymes0.80text
DNA-PKcsinstance ofand III PI3K members although it can also inhibit other PI3K-related enzymes0.80text
some phosphatidylinositol 4-kinasesinstance ofand III PI3K members although it can also inhibit other PI3K-related enzymes0.80text
myosin light chain kinaseinstance ofand III PI3K members although it can also inhibit other PI3K-related enzymes0.80text
Wortmanninrelated to DerivativesMedicinal0.60section
Wortmanninrelated to External linksWiktionary-logo-en-v20.60section
Wortmanninrelated to External linksMedia0.60section
Wortmanninrelated to External linksWikimedia Commons Wortmannin0.60section
Wortmanninrelated to External linksPDB0.60section
Wortmanninrelated to Phosphoinositide-3-kinasePhosphoinositide-3-kinase0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Wortmannin bring nearby vocabulary together. In this analysis, examples include Also, Dark and Derivatives. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Wortmannin
    • Also
    • Dark
    • Derivatives
    • Html
    • Media
    • Mw-parser-output
    • Pi3k
    • Prefers-color-scheme
    • Reported
    • Research
    • Screen
    • Skin-theme-clientpref-night
  • wortmannin
    • Also
    • Dark
    • Derivatives
    • Html
    • Media
    • Mw-parser-output
    • Pi3k
    • Prefers-color-scheme
    • Reported
    • Research
    • Screen
    • Skin-theme-clientpref-night
  • pi3k inhibitor
    • Signaling
    • Also
    • Important
    • Vitro
    • Cell
    • Inhibit
    • Ly294002
    • Wortmannin
    • Pi3k
    • Commonly
    • Ic50
    • Kinase
  • irreversible inhibitor
    • Ly294002
    • Pi3k
    • Commonly
    • Ic50
    • Kinase
    • Media
    • Mw-parser-output
    • Prefers-color-scheme
    • Screen
    • Skin-theme-clientpref-night
    • Skin-theme-clientpref-os
    • Solid
  • ii
    • Dna-pkcs
    • Iii
    • Mtor
    • Also
    • Kinase
    • Reported
    • Solid
    • Vitro
    • Inhibit
    • Sonolisib
    • Phase
    • Pi3k
  • cell biology
    • Important
    • Inhibit
    • Signaling
    • Commonly
    • Phosphoinositide-3-kinase
    • Pi3k
    • References
    • Research
    • Standard
    • State
    • Used
    • Wortmannin
  • covalent
    • Dark
    • Html
    • Media
    • Mw-parser-output
    • Prefers-color-scheme
    • Screen
    • Skin-theme-clientpref-night
    • Skin-theme-clientpref-os
    • Solid
    • Inhibitor
    • Wortmannin
  • dna-pkcs
    • Iii
    • Mtor
    • Ic50
    • Ii
    • Kinase
    • Reported
    • Vitro
    • Inhibit
    • Pi3k
    • Wortmannin

Connections between topic areas Semantic bridges

For Wortmannin, one of the stronger structural bridges in this analysis connects Wortmannin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Wortmannin — Overview · splits 7 ⟂ 20
Wortmannin — Derivatives · splits 21 ⟂ 6

Map overview Semantic statistics

Wortmannin

Nodes27
Edges26
Triples15
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around Wortmannin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Overview & Derivatives, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Wortmannin · EN edition · Analysis: TopicsToTalkAbout

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