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Insulin-like growth factor 1

Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. In the 1950s IGF1 was called "sulfation factor" because it stimulated sulfation of cartilage in vitro, and in the 1970s due to its effects it was…

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Aliases
IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Band
12q23.2 · 10 C1|10 43.7 cM
Bgee
pericardium · tail of epididymis · tendon of biceps brachii · gastric mucosa · superficial temporal artery
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

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Overview

Synthesis and circulation

Mechanism of action

Related disorders

Use as a diagnostic test

Causes of elevated IGF1 levels

Causes of reduced IGF1 levels

Health effects

Advanced semantic analysis

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Map overview Semantic statistics

Insulin-like growth factor 1

Nodes149
Edges148
Triples161
Avg. degree1.99
Density0.013423
Components1

How this topic connects Entity context

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Insulin-like growth factor 1

Top relations

Gene ontology · 84
Insulin-like growth factor 1 → activation of protein kinase B activity, alphav-beta3 integrin-IGF-1-IGF1R complex, bone mineralization involved in bone maturation, cell activation, cell population proliferation, cellular response to amyloid-beta, DNA replication, ERK1 and ERK2 cascade, exocytic vesicle, extracellular region, extracellular space, glycolate metabolic process, growth factor activity, hormone activity, insulin receptor binding, insulin-like growth factor binding protein complex, insulin-like growth factor receptor binding, insulin-like growth factor receptor signaling pathway, insulin-like growth factor ternary complex, integrin binding
Bgee · 20
Insulin-like growth factor 1 → caput epididymis, corpus epididymis, efferent ductule, endometrium, external carotid artery, gallbladder, gastric mucosa, genital tubercle, internal carotid artery, iris, left lobe of liver, pericardium, seminal vesicula, stria vascularis, stroma of bone marrow, superficial temporal artery, tail of epididymis, tendon of biceps brachii, urethra, white adipose tissue
RNA expression pattern · 20
Insulin-like growth factor 1 → caput epididymis, corpus epididymis, efferent ductule, endometrium, external carotid artery, gallbladder, gastric mucosa, genital tubercle, internal carotid artery, iris, left lobe of liver, pericardium, seminal vesicula, stria vascularis, stroma of bone marrow, superficial temporal artery, tail of epididymis, tendon of biceps brachii, urethra, white adipose tissue
related to Laron syndrome · 10
Insulin-like growth factor 1 → Affected, GH, GHR, GHRD, IGF-1, It, Laron, LS, The, Zvi Laron
Band · 2
Insulin-like growth factor 1 → 10 C1|10 43.7 cM, 12q23.2
Chr. · 2
Insulin-like growth factor 1 → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
Insulin-like growth factor 1 → 102,481,744 bp, 87,772,904 bp
Aliases · 1
Insulin-like growth factor 1 → IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Available structures · 1
Insulin-like growth factor 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
BioGPS · 1
Insulin-like growth factor 1 → More reference expression data

Important terminology Word statistics

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Important terminology

igf1 growth hormone levels cell insulin factor liver insulin-like gh effects protein metabolic associated bp also disease receptor production binding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Insulin-like growth factor 1AliasesIGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF1.00infobox
Insulin-like growth factor 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS1.00infobox
Insulin-like growth factor 1Band12q23.21.00infobox
Insulin-like growth factor 1Band10 C1|10 43.7 cM1.00infobox
Insulin-like growth factor 1Bgeepericardium1.00infobox
Insulin-like growth factor 1Bgeetail of epididymis1.00infobox
Insulin-like growth factor 1Bgeetendon of biceps brachii1.00infobox
Insulin-like growth factor 1Bgeegastric mucosa1.00infobox
Insulin-like growth factor 1Bgeesuperficial temporal artery1.00infobox
Insulin-like growth factor 1Bgeeseminal vesicula1.00infobox
Insulin-like growth factor 1Bgeeurethra1.00infobox
Insulin-like growth factor 1Bgeecaput epididymis1.00infobox
Insulin-like growth factor 1Bgeecorpus epididymis1.00infobox
Insulin-like growth factor 1Bgeeendometrium1.00infobox
Insulin-like growth factor 1Bgeestria vascularis1.00infobox
Insulin-like growth factor 1Bgeeinternal carotid artery1.00infobox
Insulin-like growth factor 1Bgeeefferent ductule1.00infobox
Insulin-like growth factor 1Bgeeexternal carotid artery1.00infobox
Insulin-like growth factor 1Bgeeiris1.00infobox
Insulin-like growth factor 1Bgeeleft lobe of liver1.00infobox
Insulin-like growth factor 1Bgeegallbladder1.00infobox
Insulin-like growth factor 1Bgeestroma of bone marrow1.00infobox
Insulin-like growth factor 1Bgeegenital tubercle1.00infobox
Insulin-like growth factor 1Bgeewhite adipose tissue1.00infobox
Insulin-like growth factor 1BioGPSMore reference expression data1.00infobox
Insulin-like growth factor 1Chr.Chromosome 12 (human)1.00infobox
Insulin-like growth factor 1Chr.Chromosome 10 (mouse)1.00infobox
Insulin-like growth factor 1DatabasesNCBI: entry; OMA: entry1.00infobox
Insulin-like growth factor 1End102,481,744 bp1.00infobox
Insulin-like growth factor 1End87,772,904 bp1.00infobox

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