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Leber's hereditary optic neuropathy

Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects adult males, and onset is more likely in younger adults. LHON is transmitted only through the…

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Frequency
1:30,000 to 1:50,000
Other names
Leber hereditary optic atrophy
Specialty
Ophthalmology

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Leber's hereditary optic neuropathy

Nodes102
Edges101
Triples25
Avg. degree1.98
Density0.019608
Components1

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Leber's hereditary optic neuropathy

Top relations

related to Further reading · 18
Leber's hereditary optic neuropathy → Carelli, Clin, Clinical, IFOND, January, Kerrison JB, Leber, Leber's, MedlinePlus, Mitochondrial, Neurosci, Newman NJ, PMID, Prog Retin Eye Res, Retrieved, Ross-Cisneros FN, S2CID, Sadun AA
Frequency · 1
Leber's hereditary optic neuropathy → 1:30,000 to 1:50,000
Other names · 1
Leber's hereditary optic neuropathy → Leber hereditary optic atrophy
Specialty · 1
Leber's hereditary optic neuropathy → Ophthalmology

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Important terminology

lhon mitochondrial idebenone mutation vision optic may loss citation needed mutations visual neuropathy eye onset disease hereditary affected retinal one

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Leber's hereditary optic neuropathyFrequency1:30,000 to 1:50,0001.00infobox
Leber's hereditary optic neuropathyOther namesLeber hereditary optic atrophy1.00infobox
Leber's hereditary optic neuropathySpecialtyOphthalmology1.00infobox
heart electrical conduction system abnormalitiesinstance ofIt is important to exclude other possible causes of vision loss and associated syndromes0.80text
smokinginstance ofEnvironmental factors0.80text
alcohol use may be involvedinstance ofEnvironmental factors0.80text
though studies of these factors have produced conflicting resultsinstance ofEnvironmental factors0.80text
Leber's hereditary optic neuropathyrelated to Further readingLeber0.60section
Leber's hereditary optic neuropathyrelated to Further readingMedlinePlus0.60section
Leber's hereditary optic neuropathyrelated to Further readingRetrieved0.60section
Leber's hereditary optic neuropathyrelated to Further readingKerrison JB0.60section
Leber's hereditary optic neuropathyrelated to Further readingNewman NJ0.60section

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