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MECR: Function, Structure & Clinical significance

Mitochondrial trans-2-enoyl-CoA reductase (MECR) is an enzyme that in humans is encoded by the MECR gene. It belongs to the enzyme class of oxidoreductases and catalyzes the last step of mitochondrial fatty acid synthesis (mtFAS). In doing so, MECR makes the fatty acyl chain bound to mitochondrial acyl carrier protein (mtACP) available again for…

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MECR topic overview

The analysis highlights Function, Structure and Clinical significance as prominent areas in the source structure around MECR.

Related topics
66
Source areas
5
Connected nodes
71
Extracted relationships
107
Concept neighborhoods
21
Bridge connections
71

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 28 topics
Overview · 15 topics
Structure · 10 topics
Clinical significance · 9 topics
Reaction · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.3.1.104
↗
Aliases
MECR, CGI-63, FASN2B, NRBF1, mitochondrial trans-2-enoyl-CoA reductase, ETR1, nuclear receptor binding factor 1, trans-2-enoyl-CoA reductase, mitochondrial, mitochondrial 2-enoy…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZSY, 2VCY
Band
1p35.3 · 4|4 D2.3
Bgee
apex of heart · muscle of thigh · gastrocnemius muscle · prefrontal cortex · anterior cingulate cortex
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Reaction

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MECR connects Entity context

The extracted context around MECR shows recurring relationship patterns in the source. For example, MECR → anterior cingulate cortex, apex of heart, brown adipose tissue, C1 segment, epithelium of stomach, gastrocnemius muscle, left colon, left ventricle, lens, lip, lumbar spinal ganglion, muscle of thigh, neural layer of retina, prefrontal cortex, primary oocyte, proximal tubule, right adrenal gland, right auricle of heart, right frontal lobe, right kidney Another extracted example is MECR → C16, C2, C8, CoA, Condensation, In, It, Longer-chain, LYRM, NADK2, NADPH, Octanoyl-mtACP, PPAR, The MECR, Through. Use these groups to spot repeated connection types before inspecting the individual relationships.

MECR

Top relations

Bgee · 20
MECR → anterior cingulate cortex, apex of heart, brown adipose tissue, C1 segment, epithelium of stomach, gastrocnemius muscle, left colon, left ventricle, lens, lip, lumbar spinal ganglion, muscle of thigh, neural layer of retina, prefrontal cortex, primary oocyte, proximal tubule, right adrenal gland, right auricle of heart, right frontal lobe, right kidney
RNA expression pattern · 20
MECR → anterior cingulate cortex, apex of heart, brown adipose tissue, C1 segment, epithelium of stomach, gastrocnemius muscle, left colon, left ventricle, lens, lip, lumbar spinal ganglion, muscle of thigh, neural layer of retina, prefrontal cortex, primary oocyte, proximal tubule, right adrenal gland, right auricle of heart, right frontal lobe, right kidney
related to Function · 15
MECR → C16, C2, C8, CoA, Condensation, In, It, Longer-chain, LYRM, NADK2, NADPH, Octanoyl-mtACP, PPAR, The MECR, Through
Gene ontology · 10
MECR → cytoplasm, fatty acid beta-oxidation, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolism, mitochondrial matrix, mitochondrion, nucleus, oxidoreductase activity, trans-2-enoyl-CoA reductase (NADPH) activity
related to Structure · 7
MECR → C16, C4, CoA, N-terminal, The, The MECR, Through
related to Clinical significance · 4
MECR → LHON-like, MEPAN, MRI, Pathogenic
Band · 2
MECR → 1p35.3, 4|4 D2.3
Chr. · 2
MECR → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
MECR → 131,595,097 bp, 29,230,942 bp
1.3.1.104 · 1
MECR → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mitochondrial gene bp fatty chr human band enzyme trans-2-enoyl-coa reductase chromosome acid mtfas nuclear chain species protein available location synthesis

MECR relationships Subject–Predicate–Object triples

TTTA extracted 107 structured relationships around MECR. Examples in this analysis include MECR → 1.3.1.104 → ↗ and MECR → Aliases → MECR, CGI-63, FASN2B, NRBF1, mitochondrial trans-2-enoyl-CoA reductase, ETR1, nuclear receptor binding factor 1, trans-2-enoyl-CoA reductase, mitochondrial, mitochondrial 2-enoy…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MECR1.3.1.104↗1.00infobox
MECRAliasesMECR, CGI-63, FASN2B, NRBF1, mitochondrial trans-2-enoyl-CoA reductase, ETR1, nuclear receptor binding factor 1, trans-2-enoyl-CoA reductase, mitochondrial, mitochondrial 2-enoy…1.00infobox
MECRAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZSY, 2VCY1.00infobox
MECRBand1p35.31.00infobox
MECRBand4|4 D2.31.00infobox
MECRBgeeapex of heart1.00infobox
MECRBgeemuscle of thigh1.00infobox
MECRBgeegastrocnemius muscle1.00infobox
MECRBgeeprefrontal cortex1.00infobox
MECRBgeeanterior cingulate cortex1.00infobox
MECRBgeeleft ventricle1.00infobox
MECRBgeeright frontal lobe1.00infobox
MECRBgeeright auricle of heart1.00infobox
MECRBgeeC1 segment1.00infobox
MECRBgeeright adrenal gland1.00infobox
MECRBgeebrown adipose tissue1.00infobox
MECRBgeeneural layer of retina1.00infobox
MECRBgeeright kidney1.00infobox
MECRBgeelens1.00infobox
MECRBgeeproximal tubule1.00infobox
MECRBgeelip1.00infobox
MECRBgeelumbar spinal ganglion1.00infobox
MECRBgeeprimary oocyte1.00infobox
MECRBgeeepithelium of stomach1.00infobox
MECRBgeeleft colon1.00infobox
MECRBioGPSMore reference expression data1.00infobox
MECRChr.Chromosome 1 (human)1.00infobox
MECRChr.Chromosome 4 (mouse)1.00infobox
MECRDatabasesNCBI: entry; OMA: entry1.00infobox
MECREnd29,230,942 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MECR bring nearby vocabulary together. In this analysis, examples include Gene, Mitochondrial and Reductase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MECR
    • Gene
    • Mitochondrial
    • Reductase
    • Trans-2-enoyl-coa
    • Fatty
    • Cause
    • Function
    • Mepan
    • Pathogenic
    • Variants
    • Acyl
    • Also
  • mecr
    • Gene
    • Mitochondrial
    • Reductase
    • Trans-2-enoyl-coa
    • Fatty
    • Cause
    • Function
    • Mepan
    • Pathogenic
    • Variants
    • Acyl
    • Also
  • gene
    • Mecr
    • Reductase
    • Trans-2-enoyl-coa
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Mitochondrial
    • Cause
    • Function
    • Mepan
  • mitochondrial fatty acid synthesis
    • Synthesis
    • Fatty
    • Mecr
    • Chain
    • Catalyzes
    • Last
    • Step
    • Mtfas
    • Acid
    • Mitochondrial
    • Reductase
    • Trans-2-enoyl-coa
  • mitochondrial acyl carrier protein
    • Chain
    • Bound
    • Mtacp
    • Mecr
    • Acid
    • Reductase
    • Trans-2-enoyl-coa
    • Fatty
    • Gene
    • Enzyme
    • Protein
    • Synthesis
  • mitochondrial
    • Mecr
    • Acid
    • Reductase
    • Trans-2-enoyl-coa
    • Fatty
    • Gene
    • Enzyme
    • Protein
    • Synthesis
    • Mtfas
    • Catalyzes
    • Cmecr
  • mitochondrial targeting sequence
    • Mecr
    • Acid
    • Reductase
    • Trans-2-enoyl-coa
    • Fatty
    • Gene
    • Enzyme
    • Protein
    • Synthesis
    • Mtfas
    • Catalyzes
    • Cmecr
  • lipoic acid
    • Synthesis
    • Fatty
    • Catalyzes
    • Last
    • Step
    • Mitochondrial
    • Protein
    • Enzyme
    • Species
    • Mtfas
    • Reductase
    • Trans-2-enoyl-coa

Connections between topic areas Semantic bridges

For MECR, one of the stronger structural bridges in this analysis connects MECR with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MECR — Function · splits 43 ⟂ 29
MECR — Overview · splits 56 ⟂ 16
MECR — Structure · splits 61 ⟂ 11
MECR — Clinical significance · splits 62 ⟂ 10
MECR — Reaction · splits 67 ⟂ 5

Map overview Semantic statistics

MECR

Nodes72
Edges71
Triples107
Avg. degree1.97
Density0.027778
Components1

Source & methodology

TTTA analyzes the structure around MECR to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MECR · EN edition · Analysis: TopicsToTalkAbout

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