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FKBP5: Function, Interactions & Structure

FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.

Language: English [EN]
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FKBP5 topic overview

The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around FKBP5.

Related topics
23
Source areas
6
Connected nodes
29
Extracted relationships
126
Concept neighborhoods
16
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics
Interactions · 5 topics
Structure · 4 topics
Overview · 2 topics
Clinical significance · 1 topics
FKBP51 Ligands · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

5.2.1.8
Aliases
FKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, FK506 binding protein 5, FKBP prolyl isomerase 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KT0, 3O5D, 3O5E, 3O5F, 3O5G, 3O5I, 3O5J, 3O5K, 3O5L, 3O5M, 3O5O, 3O5P, 3O5Q, 3O5R, 4DRH, 4DRI, 4DRK, 4DRM,…
Band
6p21.31 · 17 A3.3|17 14.66 cM
Bgee
gastric mucosa · pericardium · Skeletal muscle tissue of biceps brachii · right lung · skin of hip
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Clinical significance

FKBP51 Ligands

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How FKBP5 connects Entity context

The extracted context around FKBP5 shows recurring relationship patterns in the source. For example, FKBP5 → corpus epididymis, gastric mucosa, gastrocnemius muscle, gastrula, Gonadal ridge, lacrimal gland, left uterine tube, muscle of thigh, pericardium, primary oocyte, right lung, secondary oocyte, seminal vesicula, Skeletal muscle tissue of biceps brachii, skin of hip, skin of thigh, stroma of bone marrow, synovial joint, thymus, zygote Another extracted example is FKBP5 → chaperone-mediated protein folding, cytoplasm, cytosol, extracellular exosome, FK506 binding, heat shock protein binding, isomerase activity, membrane, nucleoplasm, nucleus, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein folding, protein peptidyl-prolyl isomerization, response to bacterium. Use these groups to spot repeated connection types before inspecting the individual relationships.

FKBP5

Top relations

Bgee · 20
FKBP5 → corpus epididymis, gastric mucosa, gastrocnemius muscle, gastrula, Gonadal ridge, lacrimal gland, left uterine tube, muscle of thigh, pericardium, primary oocyte, right lung, secondary oocyte, seminal vesicula, Skeletal muscle tissue of biceps brachii, skin of hip, skin of thigh, stroma of bone marrow, synovial joint, thymus, zygote
RNA expression pattern · 20
FKBP5 → corpus epididymis, gastric mucosa, gastrocnemius muscle, gastrula, Gonadal ridge, lacrimal gland, left uterine tube, muscle of thigh, pericardium, primary oocyte, right lung, secondary oocyte, seminal vesicula, Skeletal muscle tissue of biceps brachii, skin of hip, skin of thigh, stroma of bone marrow, synovial joint, thymus, zygote
Gene ontology · 15
FKBP5 → chaperone-mediated protein folding, cytoplasm, cytosol, extracellular exosome, FK506 binding, heat shock protein binding, isomerase activity, membrane, nucleoplasm, nucleus, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein folding, protein peptidyl-prolyl isomerization, response to bacterium
related to Structure · 14
FKBP5 → C-terminal, FK1, FK2, FKBP, FKBP-like, FKBP-type, Hsp90, In, Instead, It, PPIase, The FK1, The TPR, TPR
related to Function · 9
FKBP5 → As, FK506, FKBP51, Hsp90-associated, It, P23, PTGES3, The, This
related to AKT phosphorylation · 6
FKBP5 → AKT, FK1, PHLPP, Ser473, TPR, Without FKBP51
related to Steroid hormone regulation · 6
FKBP5 → AR, GR, In, Interestingly, PR, These
related to FKBP51 Ligands · 4
FKBP5 → As, FKBP51, Macrocyclic FKBP51-selective, SAFit2
see also · 3
FKBP5 → DNA, FKBP, FKBP4
Band · 2
FKBP5 → 17 A3.3|17 14.66 cM, 6p21.31

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene bp fkbp51 activity chr human band binding fk506 chromosome akt isomerase also ppiase location function receptors domain fk1

FKBP5 relationships Subject–Predicate–Object triples

TTTA extracted 126 structured relationships around FKBP5. Examples in this analysis include FKBP5 → 5.2.1.8 → ↗ and FKBP5 → Aliases → FKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, FK506 binding protein 5, FKBP prolyl isomerase 5. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FKBP55.2.1.81.00infobox
FKBP5AliasesFKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, FK506 binding protein 5, FKBP prolyl isomerase 51.00infobox
FKBP5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KT0, 3O5D, 3O5E, 3O5F, 3O5G, 3O5I, 3O5J, 3O5K, 3O5L, 3O5M, 3O5O, 3O5P, 3O5Q, 3O5R, 4DRH, 4DRI, 4DRK, 4DRM,…1.00infobox
FKBP5Band6p21.311.00infobox
FKBP5Band17 A3.3|17 14.66 cM1.00infobox
FKBP5Bgeegastric mucosa1.00infobox
FKBP5Bgeepericardium1.00infobox
FKBP5BgeeSkeletal muscle tissue of biceps brachii1.00infobox
FKBP5Bgeeright lung1.00infobox
FKBP5Bgeeskin of hip1.00infobox
FKBP5Bgeeskin of thigh1.00infobox
FKBP5Bgeegastrocnemius muscle1.00infobox
FKBP5Bgeeleft uterine tube1.00infobox
FKBP5Bgeecorpus epididymis1.00infobox
FKBP5Bgeesynovial joint1.00infobox
FKBP5Bgeestroma of bone marrow1.00infobox
FKBP5Bgeelacrimal gland1.00infobox
FKBP5Bgeemuscle of thigh1.00infobox
FKBP5Bgeesecondary oocyte1.00infobox
FKBP5Bgeethymus1.00infobox
FKBP5Bgeegastrula1.00infobox
FKBP5Bgeezygote1.00infobox
FKBP5Bgeeprimary oocyte1.00infobox
FKBP5BgeeGonadal ridge1.00infobox
FKBP5Bgeeseminal vesicula1.00infobox
FKBP5BioGPSMore reference expression data1.00infobox
FKBP5Chr.Chromosome 6 (human)1.00infobox
FKBP5Chr.Chromosome 17 (mouse)1.00infobox
FKBP5DatabasesNCBI: entry; OMA: entry1.00infobox
FKBP5End35,728,583 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around FKBP5 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • FKBP5
    • Gene
    • Protein
    • Activity
    • Fkbp
    • Akt
    • Receptors
    • Search
    • Function
    • Heat
    • Hormone
    • Location
    • Phlpp
  • fkbp5
    • Gene
    • Protein
    • Activity
    • Fkbp
    • Akt
    • Receptors
    • Search
    • Function
    • Heat
    • Hormone
    • Location
    • Phlpp
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Mouse
    • Search
    • Function
    • Protein
    • Band
    • Isomerase
  • cis-trans prolyl isomerase
    • Cis-trans
    • Isomerase
    • Encoded
    • Search
    • Fk506
    • Location
    • Ppiase
    • Protein
    • End
    • Folding
    • Mouse
    • Cellular
  • 90 kda heat shock protein
    • Heat
    • Shock
    • Protein
    • Isomerase
    • Cellular
    • End
    • Folding
    • Mouse
    • Search
    • Cis-trans
    • Location
    • Also
  • peptidyl-prolyl cis-trans isomerase
    • Cis-trans
    • Isomerase
    • Encoded
    • Search
    • Fk506
    • Location
    • Ppiase
    • Protein
    • End
    • Folding
    • Mouse
    • Cellular
  • heat shock protein 90kda alpha (cytosolic), member a1
    • Heat
    • Shock
    • Protein
    • Isomerase
    • Cellular
    • End
    • Folding
    • Mouse
    • Search
    • Cis-trans
    • Location
    • Also
  • akt
    • Phlpp
    • Activity
    • Fkbp51
    • Fkbp5
    • Search
    • Also
    • Fkbp
    • Function
    • Hormone
    • Interactions
    • Location
    • Steroid

Connections between topic areas Semantic bridges

For FKBP5, one of the stronger structural bridges in this analysis connects FKBP5 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FKBP5Function · splits 19 ⟂ 11
FKBP5Interactions · splits 24 ⟂ 6
FKBP5Structure · splits 25 ⟂ 5
FKBP5Overview · splits 27 ⟂ 3

Map overview Semantic statistics

FKBP5

Nodes30
Edges29
Triples126
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around FKBP5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FKBP5 · EN edition · Analysis: TopicsToTalkAbout

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