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Protein phosphorylation

Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or otherwise modifying its function.…

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History

AlsbergFritz LipmannPhosphoserineCaseinPhosvitin
20 related topics

Mechanisms and functions of phosphorylation

Side chainP53Conformational changeEnzymesReceptors
32 related topics

Sites

PyrophosphatesE. coliAlkaline phosphatasePeriplasmicH. sapiens
19 related topics

Detection and characterization

2D gelsETDEThcDMicroscale thermophoresisFRET
7 related topics

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Overview

History

Abundance

Mechanisms and functions of phosphorylation

Kinases

Receptor tyrosine kinases

Sites

Detection and characterization

Evolution

Pathology

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Protein phosphorylation

Nodes133
Edges132
Triples85
Avg. degree1.99
Density0.015038
Components1

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Protein phosphorylation

Top relations

related to Evolution · 15
Protein phosphorylation → CDK, CDKs, Conversely, However, In, It, Most, Positioning, Protein, Some, Targets, The, There, These, While CDK
related to Pathology · 15
Protein phosphorylation → Abnormal, Alzheimer, Alzheimer's, Association, In Alzheimer's, MAP1, MAP2, MAPs, Parkinson's, Phosphatases PP1, PP2A, PP2B, PP2C, Tau, The
related to Kinases · 12
Protein phosphorylation → Histidine, However, In, OH, Once, Phosphorylation, Ser, The, Thr, Tyr, Tyrosine, Within
related to Comparisons between eukaryotes and prokaryotes · 10
Protein phosphorylation → Compared, DNA, Hanks-type, In, It, Protein, PTSs, These, Whether, While
related to Non-canonical phosphorylation on His, Asp, Cys, Glu, Arg and Lys in human cells · 6
Protein phosphorylation → Due, HeLa, Ser, Thr, Tyr, Widespread
is a · 1
Protein phosphorylation → reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group

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Important terminology

phosphorylation protein proteins phosphorylated tyrosine serine sites kinases kinase cell signaling threonine eukaryotes histidine bacteria amino eukaryotic α-synuclein enzyme residues

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Protein phosphorylationis areversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group0.90text
p53 contain multiple phosphorylation sitesinstance ofSome proteins0.80text
facilitating complexinstance ofSome proteins0.80text
multi-level regulationinstance ofSome proteins0.80text
phosphoproteomicsinstance ofGlobal approaches0.80text
the study of phosphorylated proteinsinstance ofGlobal approaches0.80text
which is a sub-branch of proteomicsinstance ofGlobal approaches0.80text
combined with mass spectrometry-based proteomicsinstance ofGlobal approaches0.80text
have been utilised to identifyinstance ofGlobal approaches0.80text
quantify dynamic changes in phosphorylated proteins over timeinstance ofGlobal approaches0.80text
transcriptioninstance ofit has a negative impact on several fundamental biological processes0.80text
replicationinstance ofit has a negative impact on several fundamental biological processes0.80text

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