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Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes…
The analysis highlights Applications, Role in cancer and Diagnostic uses as prominent areas in the source structure around Mucin short variant S1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Mucin short variant S1 shows recurring relationship patterns in the source. For example, Mucin short variant S1 → apical plasma membrane, cytokine-mediated signaling pathway, cytoplasm, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, extracellular exosome, extracellular region, extracellular space, Golgi lumen, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of cell adhesion mediated by integrin, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of transcription by competitive promoter binding, nucleus, O-glycan processing, p53 binding, plasma membrane, positive regulation of histone H4 acetylation Another extracted example is Mucin short variant S1 → buccal mucosa cell, cardia, gastric mucosa, lower lobe of lung, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, pancreatic ductal cell, pylorus, right uterine tube. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
muc1 cell cancer domain extracellular surface gene glycosylation protein associated cells breast beta-catenin ca mucin cytoplasmic tail shown human 15-3
TTTA extracted 67 structured relationships around Mucin short variant S1. Examples in this analysis include Mucin short variant S1 → Aliases → MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca… and Mucin short variant S1 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1SM3, 2ACM. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Mucin short variant S1 | Aliases | MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca… | 1.00 | infobox |
| Mucin short variant S1 | Available structures | Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1SM3, 2ACM | 1.00 | infobox |
| Mucin short variant S1 | Band | 1q22 | 1.00 | infobox |
| Mucin short variant S1 | Bgee | pylorus | 1.00 | infobox |
| Mucin short variant S1 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| Mucin short variant S1 | Bgee | nasal epithelium | 1.00 | infobox |
| Mucin short variant S1 | Bgee | right uterine tube | 1.00 | infobox |
| Mucin short variant S1 | Bgee | cardia | 1.00 | infobox |
| Mucin short variant S1 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| Mucin short variant S1 | Bgee | lower lobe of lung | 1.00 | infobox |
| Mucin short variant S1 | Bgee | buccal mucosa cell | 1.00 | infobox |
| Mucin short variant S1 | Bgee | gastric mucosa | 1.00 | infobox |
| Mucin short variant S1 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| Mucin short variant S1 | BioGPS | More reference expression data | 1.00 | infobox |
| Mucin short variant S1 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| Mucin short variant S1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Mucin short variant S1 | End | 155,192,916 bp | 1.00 | infobox |
| Mucin short variant S1 | Ensembl | ENSG00000185499 | 1.00 | infobox |
| Mucin short variant S1 | Entrez | 4582 | 1.00 | infobox |
| Mucin short variant S1 | External IDs | OMIM: 158340; GeneCards: MUC1 | 1.00 | infobox |
| Mucin short variant S1 | Gene location (Human) | Gene location (Human)Chr.Chromosome 1 (human)Band1q22Start155,185,824 bpEnd155,192,916 bp | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | protein binding | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | transcription coregulator activity | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | p53 binding | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | extracellular region | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | cytoplasm | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | integral component of membrane | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | nucleus | 1.00 | infobox |
| Mucin short variant S1 | Gene ontology | Golgi lumen | 1.00 | infobox |
The concept neighborhoods around Mucin short variant S1 bring nearby vocabulary together. In this analysis, examples include Human, Preventing and P53. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Mucin short variant S1, one of the stronger structural bridges in this analysis connects Mucin short variant S1 with Role in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Mucin short variant S1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Role in cancer & Diagnostic uses, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Mucin short variant S1 · EN edition · Analysis: TopicsToTalkAbout