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Mucin short variant S1: Applications, Role in cancer & Diagnostic uses

Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes…

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Mucin short variant S1 topic overview

The analysis highlights Applications, Role in cancer and Diagnostic uses as prominent areas in the source structure around Mucin short variant S1.

Related topics
66
Source areas
7
Connected nodes
73
Extracted relationships
67
Concept neighborhoods
13
Bridge connections
73

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in cancer · 28 topics
Diagnostic uses · 10 topics
Structure · 8 topics
Overview · 7 topics
Interactions · 6 topics
As a therapeutic drug target · 4 topics
Function · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca…
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1SM3, 2ACM
Band
1q22
Bgee
pylorus · pancreatic ductal cell · nasal epithelium · right uterine tube · cardia
BioGPS
More reference expression data
Chr.
Chromosome 1 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Interactions

Role in cancer

Diagnostic uses

As a therapeutic drug target

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mucin short variant S1 connects Entity context

The extracted context around Mucin short variant S1 shows recurring relationship patterns in the source. For example, Mucin short variant S1 → apical plasma membrane, cytokine-mediated signaling pathway, cytoplasm, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, extracellular exosome, extracellular region, extracellular space, Golgi lumen, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of cell adhesion mediated by integrin, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of transcription by competitive promoter binding, nucleus, O-glycan processing, p53 binding, plasma membrane, positive regulation of histone H4 acetylation Another extracted example is Mucin short variant S1 → buccal mucosa cell, cardia, gastric mucosa, lower lobe of lung, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, pancreatic ductal cell, pylorus, right uterine tube. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mucin short variant S1

Top relations

Gene ontology · 27
Mucin short variant S1 → apical plasma membrane, cytokine-mediated signaling pathway, cytoplasm, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, extracellular exosome, extracellular region, extracellular space, Golgi lumen, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of cell adhesion mediated by integrin, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of transcription by competitive promoter binding, nucleus, O-glycan processing, p53 binding, plasma membrane, positive regulation of histone H4 acetylation
Bgee · 10
Mucin short variant S1 → buccal mucosa cell, cardia, gastric mucosa, lower lobe of lung, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, pancreatic ductal cell, pylorus, right uterine tube
RNA expression pattern · 10
Mucin short variant S1 → buccal mucosa cell, cardia, gastric mucosa, lower lobe of lung, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, pancreatic ductal cell, pylorus, right uterine tube
Aliases · 1
Mucin short variant S1 → MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca…
Available structures · 1
Mucin short variant S1 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1SM3, 2ACM
Band · 1
Mucin short variant S1 → 1q22
BioGPS · 1
Mucin short variant S1 → More reference expression data
Chr. · 1
Mucin short variant S1 → Chromosome 1 (human)
Databases · 1
Mucin short variant S1 → NCBI: entry; OMA: entry
End · 1
Mucin short variant S1 → 155,192,916 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

muc1 cell cancer domain extracellular surface gene glycosylation protein associated cells breast beta-catenin ca mucin cytoplasmic tail shown human 15-3

Mucin short variant S1 relationships Subject–Predicate–Object triples

TTTA extracted 67 structured relationships around Mucin short variant S1. Examples in this analysis include Mucin short variant S1 → Aliases → MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca… and Mucin short variant S1 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1SM3, 2ACM. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mucin short variant S1AliasesMUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca…1.00infobox
Mucin short variant S1Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1SM3, 2ACM1.00infobox
Mucin short variant S1Band1q221.00infobox
Mucin short variant S1Bgeepylorus1.00infobox
Mucin short variant S1Bgeepancreatic ductal cell1.00infobox
Mucin short variant S1Bgeenasal epithelium1.00infobox
Mucin short variant S1Bgeeright uterine tube1.00infobox
Mucin short variant S1Bgeecardia1.00infobox
Mucin short variant S1Bgeeolfactory zone of nasal mucosa1.00infobox
Mucin short variant S1Bgeelower lobe of lung1.00infobox
Mucin short variant S1Bgeebuccal mucosa cell1.00infobox
Mucin short variant S1Bgeegastric mucosa1.00infobox
Mucin short variant S1Bgeepalpebral conjunctiva1.00infobox
Mucin short variant S1BioGPSMore reference expression data1.00infobox
Mucin short variant S1Chr.Chromosome 1 (human)1.00infobox
Mucin short variant S1DatabasesNCBI: entry; OMA: entry1.00infobox
Mucin short variant S1End155,192,916 bp1.00infobox
Mucin short variant S1EnsemblENSG000001854991.00infobox
Mucin short variant S1Entrez45821.00infobox
Mucin short variant S1External IDsOMIM: 158340; GeneCards: MUC11.00infobox
Mucin short variant S1Gene location (Human)Gene location (Human)Chr.Chromosome 1 (human)Band1q22Start155,185,824 bpEnd155,192,916 bp1.00infobox
Mucin short variant S1Gene ontologyprotein binding1.00infobox
Mucin short variant S1Gene ontologytranscription coregulator activity1.00infobox
Mucin short variant S1Gene ontologyRNA polymerase II cis-regulatory region sequence-specific DNA binding1.00infobox
Mucin short variant S1Gene ontologyp53 binding1.00infobox
Mucin short variant S1Gene ontologyextracellular region1.00infobox
Mucin short variant S1Gene ontologycytoplasm1.00infobox
Mucin short variant S1Gene ontologyintegral component of membrane1.00infobox
Mucin short variant S1Gene ontologynucleus1.00infobox
Mucin short variant S1Gene ontologyGolgi lumen1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mucin short variant S1 bring nearby vocabulary together. In this analysis, examples include Human, Preventing and P53. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Mucin
    • Bp
    • Membrane
    • 15-3
    • Human
    • P53
    • Promoter
    • Ca
    • Associated
    • Muc1
    • Protein
    • Apical
  • src (gene)
    • Mucin
    • Bp
    • Membrane
    • 15-3
    • Human
    • P53
    • Promoter
    • Ca
    • Associated
    • Muc1
    • Protein
    • Apical
  • anaplastic large cell lymphoma
    • Surface
    • Muc1
    • Cancer
    • Protein
    • Bp
    • Ema
    • Preventing
    • Human
    • Mucin
    • P53
    • Expression
    • Prevents
  • role in cancer
    • Cells
    • Muc1
    • 15-3
    • Ca
    • Cell
    • Expression
    • Increased
    • Beta-catenin
    • Gene
    • Surface
    • Bp
    • Ema
  • immune cells
    • Cancer
    • Epithelial
    • Surface
    • Muc1
    • Mucins
    • Cell
    • Expression
    • Increased
    • Prevents
    • Beta-catenin
    • Glycosylation
    • Interaction
  • o-linked glycosylation
    • Extracellular
    • Domain
    • Protein
    • Mucin
    • Overexpression
    • Prevents
    • Associated
    • Cells
    • Shown
    • Cancer
    • Muc1
  • tumour antigen
    • Breast
    • Gene
    • Ema
    • Epithelial
    • Membrane
    • 15-3
    • Mucin
    • Ca
    • Protein
    • Muc1
    • Cancer
  • beta-catenin
    • Expression
    • Increased
    • Muc1
    • Binding
    • Cancer
    • Interaction
    • Cells
    • Cytoplasmic
    • Shown
    • Tail
    • Cell

Connections between topic areas Semantic bridges

For Mucin short variant S1, one of the stronger structural bridges in this analysis connects Mucin short variant S1 with Role in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Mucin short variant S1Role in cancer · splits 45 ⟂ 29
Mucin short variant S1Diagnostic uses · splits 63 ⟂ 11
Mucin short variant S1Structure · splits 65 ⟂ 9
Mucin short variant S1Overview · splits 66 ⟂ 8
Mucin short variant S1Interactions · splits 67 ⟂ 7
Mucin short variant S1As a therapeutic drug target · splits 69 ⟂ 5
Mucin short variant S1Function · splits 70 ⟂ 4

Map overview Semantic statistics

Mucin short variant S1

Nodes74
Edges73
Triples67
Avg. degree1.97
Density0.027027
Components1

Source & methodology

TTTA analyzes the structure around Mucin short variant S1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Role in cancer & Diagnostic uses, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mucin short variant S1 · EN edition · Analysis: TopicsToTalkAbout

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