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Donepezil: History, Applications & Research

Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. It appears to result in a small benefit in mental function and ability to function. Use, however, has not been shown to change the progression of the disease. Treatment should be stopped if no benefit is seen. It is taken by mouth or…

Language: English [EN]
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Donepezil topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Donepezil.

Related topics
73
Source areas
7
Connected nodes
80
Extracted relationships
112
Concept neighborhoods
29
Bridge connections
80

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Research · 26 topics
Mechanism of action · 12 topics
Overview · 12 topics
Adverse effects · 10 topics
Medical uses · 7 topics
History · 5 topics
Stereochemistry · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06DA02 (WHO)
Bioavailability
100%
CAS Number
120014-06-4 Y
ChEBI
CHEBI:53289 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Mechanism of action

Stereochemistry

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Donepezil connects Entity context

The extracted context around Donepezil shows recurring relationship patterns in the source. For example, Donepezil → Alzheimer's, Aricept, As, Drug Administration, Eisai, FDA, Hachiro Sugimoto, November, Pfizer, Ranbaxy Labs, Research, The, United States Food, US FDA Another extracted example is Donepezil → Alzheimer's, Clinical Excellence, Drug Administration, FDA, Food, In, NICE, Six-to-twelve-month, The, The UK National Institute, There. Use these groups to spot repeated connection types before inspecting the individual relationships.

Donepezil

Top relations

related to history · 14
Donepezil → Alzheimer's, Aricept, As, Drug Administration, Eisai, FDA, Hachiro Sugimoto, November, Pfizer, Ranbaxy Labs, Research, The, United States Food, US FDA
related to Alzheimer's disease · 11
Donepezil → Alzheimer's, Clinical Excellence, Drug Administration, FDA, Food, In, NICE, Six-to-twelve-month, The, The UK National Institute, There
related to Research · 10
Donepezil → Alzheimer's, At, CADASIL, Down, E4, Health, In, It, Lewy, National Institutes
related to Other · 7
Donepezil → Dementia, Lewy, Parkinson's, Some, Studies, Traumatic, Vascular
Legal status · 6
Donepezil → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
has effect · 6
Donepezil → Dosing, In, Most, Other, REM, Side
related to ADHD · 5
Donepezil → ADHD, ADHD's, In, The, Tourette
related to Precautions · 5
Donepezil → Although, NSAIDs, People, Slow, These
related to Synergy · 5
Donepezil → Alzheimer's, FK960, FK962, However, Phase II
related to Anorexia nervosa · 4
Donepezil → Based, Emerging, Habit, However

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

disease effects alzheimer's dementia people shown treatment action patients mild use side medication cognitive acetylcholinesterase also however disorder aricept may

Donepezil relationships Subject–Predicate–Object triples

TTTA extracted 112 structured relationships around Donepezil. Examples in this analysis include Donepezil → 3D model (JSmol) → Interactive image and Donepezil → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Donepezil3D model (JSmol)Interactive image1.00infobox
DonepezilAHFS/Drugs.comMonograph1.00infobox
DonepezilATC codeN06DA02 (WHO)1.00infobox
DonepezilBioavailability100%1.00infobox
DonepezilCAS Number120014-06-4 Y1.00infobox
DonepezilChEBICHEBI:53289 Y1.00infobox
DonepezilChEMBLChEMBL502 Y1.00infobox
DonepezilChemSpider3040 Y1.00infobox
DonepezilChiralityRacemic mixture1.00infobox
DonepezilCompTox Dashboard (EPA)DTXSID80483171.00infobox
DonepezilDrug classAcetylcholinesterase inhibitor1.00infobox
DonepezilDrugBankDB00843 Y1.00infobox
DonepezilDuration of actionWith daily dosing, steady-state concentration is reached in 15–21 days.1.00infobox
DonepezilECHA InfoCard100.125.1981.00infobox
DonepezilElimination half-life70 hours Around 100 hours in elderly patients.1.00infobox
DonepezilExcretion0.11–0.13 (L/h/kg); excreted mostly by the kidneys. Around 17% is excreted unchanged in the urine. About 15% to 20% is excreted in feces. Steady-state clearance is similar at al…1.00infobox
DonepezilFormulaC24H29NO31.00infobox
DonepezilIUPHAR/BPS65991.00infobox
DonepezilKEGGD07869 Y1.00infobox
DonepezilLegal statusAU: S4 (Prescription only)1.00infobox
DonepezilLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DonepezilLegal statusCA: ℞-only1.00infobox
DonepezilLegal statusUK: POM (Prescription only)1.00infobox
DonepezilLegal statusUS: ℞-only1.00infobox
DonepezilLegal statusIn general: ℞ (Prescription only)1.00infobox
DonepezilLicense dataUS DailyMed: Donepezil1.00infobox
DonepezilMedlinePlusa6970321.00infobox
DonepezilMetabolismCYP2D6, CYP3A4, and glucuronidation. Four major metabolites, two of which are active.1.00infobox
DonepezilMolar mass379.500 g·mol−11.00infobox
DonepezilOnset of actionPeak plasma levels in 3–4 h.1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Donepezil bring nearby vocabulary together. In this analysis, examples include Dementia, Alzheimer's and Disease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Donepezil
    • Dementia
    • Alzheimer's
    • Disease
    • Cognitive
    • Disorder
    • Mild
    • Shown
    • Treatment
    • Acetylcholinesterase
    • Administration
    • People
    • Effects
  • donepezil
    • Dementia
    • Alzheimer's
    • Disease
    • Cognitive
    • Disorder
    • Mild
    • Shown
    • Treatment
    • Acetylcholinesterase
    • Administration
    • People
    • Effects
  • alzheimer's type
    • Disease
    • Mild
    • Aricept
    • Also
    • Donepezil
    • Treatment
    • Administration
    • Action
    • Dementia
    • People
    • Approved
    • Inhibitor
  • parkinson's disease
    • Donepezil
    • Mild
    • Treatment
    • Progression
    • Administration
    • However
    • Use
    • Action
    • People
    • Approved
    • Heart
    • Inhibitor
  • parkinson's disease dementia
    • Cognitive
    • Approved
    • Donepezil
    • Mild
    • Treatment
    • Progression
    • Shown
    • Administration
    • However
    • Use
    • Action
    • Alzheimer's
  • heart disease
    • People
    • Seen
    • Donepezil
    • Mild
    • Treatment
    • May
    • Progression
    • Administration
    • Side
    • However
    • Use
    • Action
  • chronic obstructive pulmonary disease
    • Donepezil
    • Mild
    • Treatment
    • Progression
    • Administration
    • However
    • Use
    • Action
    • People
    • Approved
    • Heart
    • Inhibitor
  • peptic ulcer disease
    • Donepezil
    • Mild
    • Treatment
    • Progression
    • Administration
    • However
    • Use
    • Action
    • People
    • Approved
    • Heart
    • Inhibitor

Connections between topic areas Semantic bridges

For Donepezil, one of the stronger structural bridges in this analysis connects Donepezil with Research. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Donepezil — Research · splits 54 ⟂ 27
Donepezil — Overview · splits 68 ⟂ 13
Donepezil — Mechanism of action · splits 68 ⟂ 13
Donepezil — Adverse effects · splits 70 ⟂ 11
Donepezil — Medical uses · splits 73 ⟂ 8
Donepezil — History · splits 75 ⟂ 6

Map overview Semantic statistics

Donepezil

Nodes81
Edges80
Triples112
Avg. degree1.98
Density0.024691
Components1

Source & methodology

TTTA analyzes the structure around Donepezil to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Donepezil · EN edition · Analysis: TopicsToTalkAbout

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