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Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. It appears to result in a small benefit in mental function and ability to function.
History, Applications & Research
Explore the main themes, entities and connections around Donepezil. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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disease effects alzheimer's dementia people shown treatment action patients mild use side medication cognitive acetylcholinesterase also however disorder aricept may
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Donepezil | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Donepezil | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Donepezil | ATC code | N06DA02 (WHO) | 1.00 | infobox |
| Donepezil | Bioavailability | 100% | 1.00 | infobox |
| Donepezil | CAS Number | 120014-06-4 Y | 1.00 | infobox |
| Donepezil | ChEBI | CHEBI:53289 Y | 1.00 | infobox |
| Donepezil | ChEMBL | ChEMBL502 Y | 1.00 | infobox |
| Donepezil | ChemSpider | 3040 Y | 1.00 | infobox |
| Donepezil | Chirality | Racemic mixture | 1.00 | infobox |
| Donepezil | CompTox Dashboard (EPA) | DTXSID8048317 | 1.00 | infobox |
| Donepezil | Drug class | Acetylcholinesterase inhibitor | 1.00 | infobox |
| Donepezil | DrugBank | DB00843 Y | 1.00 | infobox |
| Donepezil | Duration of action | With daily dosing, steady-state concentration is reached in 15–21 days. | 1.00 | infobox |
| Donepezil | ECHA InfoCard | 100.125.198 | 1.00 | infobox |
| Donepezil | Elimination half-life | 70 hours Around 100 hours in elderly patients. | 1.00 | infobox |
| Donepezil | Excretion | 0.11–0.13 (L/h/kg); excreted mostly by the kidneys. Around 17% is excreted unchanged in the urine. About 15% to 20% is excreted in feces. Steady-state clearance is similar at al… | 1.00 | infobox |
| Donepezil | Formula | C24H29NO3 | 1.00 | infobox |
| Donepezil | IUPHAR/BPS | 6599 | 1.00 | infobox |
| Donepezil | KEGG | D07869 Y | 1.00 | infobox |
| Donepezil | Legal status | AU: S4 (Prescription only) | 1.00 | infobox |
| Donepezil | Legal status | BR: Class C1 (Other controlled substances) | 1.00 | infobox |
| Donepezil | Legal status | CA: ℞-only | 1.00 | infobox |
| Donepezil | Legal status | UK: POM (Prescription only) | 1.00 | infobox |
| Donepezil | Legal status | US: ℞-only | 1.00 | infobox |
| Donepezil | Legal status | In general: ℞ (Prescription only) | 1.00 | infobox |
| Donepezil | License data | US DailyMed: Donepezil | 1.00 | infobox |
| Donepezil | MedlinePlus | a697032 | 1.00 | infobox |
| Donepezil | Metabolism | CYP2D6, CYP3A4, and glucuronidation. Four major metabolites, two of which are active. | 1.00 | infobox |
| Donepezil | Molar mass | 379.500 g·mol−1 | 1.00 | infobox |
| Donepezil | Onset of action | Peak plasma levels in 3–4 h. | 1.00 | infobox |
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