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Major prion protein: Applications, Structure & Diseases caused by PrP misfolding
The major prion protein (PrP) is encoded in the human body by the PRNP gene also known as CD230 (cluster of differentiation 230). Expression of the protein is most prominent in the nervous system but occurs in many other tissues throughout the body.
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Major prion protein topic overview
The analysis highlights Applications, Structure and Diseases caused by PrP misfolding as prominent areas in the source structure around Major prion protein.
Related topics
148
Source areas
6
Connected nodes
154
Extracted relationships
149
Concept neighborhoods
32
Bridge connections
154
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Structure · 50 topics
Diseases caused by PrP misfolding · 38 topics
Overview · 36 topics
Function · 17 topics
Interactions · 5 topics
Gene · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…
Band
20p13 · 2 F2|2 64.07 cM
Bgee
Brodmann area 23 · Region I of hippocampus proper · retinal pigment epithelium · orbitofrontal cortex · endothelial cell
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Major prion protein connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Major prion protein shows recurring relationship patterns in the source. For example, Major prion protein → activation of protein kinase activity, amyloid-beta binding, anchored component of external side of plasma membrane, anchored component of membrane, ATP-dependent protein binding, calcium-mediated signaling using intracellular calcium source, cell cycle, cell surface, cellular copper ion homeostasis, cellular response to amyloid-beta, cellular response to copper ion, chaperone binding, copper ion binding, cupric ion binding, cuprous ion binding, cytoplasm, cytosol, dendrite, dendritic spine maintenance, endoplasmic reticulum Another extracted example is Major prion protein → amygdala, anterior amygdaloid area, Brodmann area 23, CA3 field, cingulate gyrus, decidua, endothelial cell, entorhinal cortex, Epithelium of choroid plexus, nucleus of stria terminalis, orbitofrontal cortex, pars compacta, perirhinal cortex, pons, Region I of hippocampus proper, retinal pigment epithelium, spinal ganglia, subiculum, trigeminal ganglion. Use these groups to spot repeated connection types before inspecting the individual relationships.
Major prion protein
Top relations
Gene ontology· 86
Major prion protein → activation of protein kinase activity, amyloid-beta binding, anchored component of external side of plasma membrane, anchored component of membrane, ATP-dependent protein binding, calcium-mediated signaling using intracellular calcium source, cell cycle, cell surface, cellular copper ion homeostasis, cellular response to amyloid-beta, cellular response to copper ion, chaperone binding, copper ion binding, cupric ion binding, cuprous ion binding, cytoplasm, cytosol, dendrite, dendritic spine maintenance, endoplasmic reticulum
Bgee· 19
Major prion protein → amygdala, anterior amygdaloid area, Brodmann area 23, CA3 field, cingulate gyrus, decidua, endothelial cell, entorhinal cortex, Epithelium of choroid plexus, nucleus of stria terminalis, orbitofrontal cortex, pars compacta, perirhinal cortex, pons, Region I of hippocampus proper, retinal pigment epithelium, spinal ganglia, subiculum, trigeminal ganglion
RNA expression pattern· 19
Major prion protein → amygdala, anterior amygdaloid area, Brodmann area 23, CA3 field, cingulate gyrus, decidua, endothelial cell, entorhinal cortex, Epithelium of choroid plexus, nucleus of stria terminalis, orbitofrontal cortex, pars compacta, perirhinal cortex, pons, Region I of hippocampus proper, retinal pigment epithelium, spinal ganglia, subiculum, trigeminal ganglion
Band· 2
Major prion protein → 2 F2|2 64.07 cM, 20p13
Chr.· 2
Major prion protein → Chromosome 2 (mouse), Chromosome 20 (human)
End· 2
Major prion protein → 131,780,349 bp, 4,701,590 bp
Aliases· 1
Major prion protein → PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
Available structures· 1
Major prion protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…
BioGPS· 1
Major prion protein → More reference expression data
Databases· 1
Major prion protein → NCBI: entry; OMA: entry
Important terminology
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Major prion protein relationships Subject–Predicate–Object triples
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 149 structured relationships around Major prion protein. Examples in this analysis include Major prion protein → Aliases → PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein and Major prion protein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…
1.00
infobox
Major prion protein
Band
20p13
1.00
infobox
Major prion protein
Band
2 F2|2 64.07 cM
1.00
infobox
Major prion protein
Bgee
Brodmann area 23
1.00
infobox
Major prion protein
Bgee
Region I of hippocampus proper
1.00
infobox
Major prion protein
Bgee
retinal pigment epithelium
1.00
infobox
Major prion protein
Bgee
orbitofrontal cortex
1.00
infobox
Major prion protein
Bgee
endothelial cell
1.00
infobox
Major prion protein
Bgee
spinal ganglia
1.00
infobox
Major prion protein
Bgee
trigeminal ganglion
1.00
infobox
Major prion protein
Bgee
pons
1.00
infobox
Major prion protein
Bgee
Epithelium of choroid plexus
1.00
infobox
Major prion protein
Bgee
pars compacta
1.00
infobox
Major prion protein
Bgee
nucleus of stria terminalis
1.00
infobox
Major prion protein
Bgee
CA3 field
1.00
infobox
Major prion protein
Bgee
entorhinal cortex
1.00
infobox
Major prion protein
Bgee
perirhinal cortex
1.00
infobox
Major prion protein
Bgee
amygdala
1.00
infobox
Major prion protein
Bgee
decidua
1.00
infobox
Major prion protein
Bgee
cingulate gyrus
1.00
infobox
Major prion protein
Bgee
subiculum
1.00
infobox
Major prion protein
Bgee
anterior amygdaloid area
1.00
infobox
Major prion protein
BioGPS
More reference expression data
1.00
infobox
Major prion protein
Chr.
Chromosome 20 (human)
1.00
infobox
Major prion protein
Chr.
Chromosome 2 (mouse)
1.00
infobox
Major prion protein
Databases
NCBI: entry; OMA: entry
1.00
infobox
Major prion protein
End
4,701,590 bp
1.00
infobox
Major prion protein
End
131,780,349 bp
1.00
infobox
Major prion protein
Ensembl
ENSG00000171867
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Major prion protein bring nearby vocabulary together. In this analysis, examples include Diseases, Disease and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Major prion protein
Diseases
Disease
Gene
Protein
Human
Prpsc
Prnp
Expression
External
Kuru
Fatal
Prpc
major prion protein
Diseases
Disease
Gene
Protein
Human
Prnp
Prp
Prpsc
Citation
Needed
Expression
Prpc
gene
Human
Chromosome
Bp
Chr
Prnp
Expression
Protein
Prion
Diseases
Band
Citation
External
protein
Prnp
Prp
Citation
Needed
Expression
Prpc
Diseases
Prpsc
Chromosome
External
Bp
Chr
scrapie
Diseases
Kuru
Fatal
Normal
Polymorphisms
Isoform
Disease
Citation
Needed
Human
Associated
Function
chronic wasting disease
Kuru
Fatal
Ad
Prion
Diseases
Scrapie
Human
Prnp
Prpc
Gene
Prpsc
Chromosome
creutzfeldt–jakob disease
Kuru
Fatal
Ad
Prion
Diseases
Scrapie
Human
Prnp
Prpc
Gene
Prpsc
Chromosome
variant creutzfeldt–jakob disease
Kuru
Fatal
Ad
Prion
Diseases
Scrapie
Human
Prnp
Prpc
Gene
Prpsc
Chromosome
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Major prion protein, one of the stronger structural bridges in this analysis connects Major prion protein with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Min side: 3
Major prion protein — Structure· splits 104 ⟂ 51Major prion protein — Diseases caused by PrP misfolding· splits 116 ⟂ 39Major prion protein — Overview· splits 118 ⟂ 37Major prion protein — Function· splits 137 ⟂ 18Major prion protein — Interactions· splits 149 ⟂ 6Major prion protein — Gene· splits 152 ⟂ 3
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Major prion protein
Nodes155
Edges154
Triples149
Avg. degree1.99
Density0.012903
Components1
Source & methodology
TTTA analyzes the structure around Major prion protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Structure & Diseases caused by PrP misfolding, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
