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Excitotoxicity

Excitotoxicity is when nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters such as glutamate become pathologically high, resulting in excessive stimulation of receptors. For example, when glutamate receptors such as NMDA receptors or AMPA receptors encounter excessive levels of the excitatory…

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Overview

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Pathophysiology

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Map overview Semantic statistics

Excitotoxicity

Nodes106
Edges105
Triples61
Avg. degree1.98
Density0.018868
Components1

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Excitotoxicity

Top relations

related to BMAA · 25
Excitotoxicity → ALS/PDC, Alzheimer's, Alzheimer's Disease, AMPA, APOE-ε4, BMAA, Ca2, Chamorro, Chlorocebus, Following, Further, Guam, Kitts, L-alanine, L-serine, Lytico-bodig, MK801, More, NMDA, St
related to history · 13
Excitotoxicity → Disruption, Hayashi, He, Hilmar Bading, In, Japanese, John Olney, Lucas, Newhouse, NMDA, NMDAR/TRPM4, The, TRPM4
related to Pathophysiology · 9
Excitotoxicity → Because, Brain, During, Glutamate, Ischemia, The, This, When, Within

Important terminology Word statistics

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Important terminology

glutamate nmda bmaa brain receptors also levels receptor concentrations cell extracellular may high apoptosis ampa cells neurons damage calcium concentration

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
glutamate become pathologically highinstance ofExcitotoxicity is when nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters0.80text
resulting in excessive stimulation of receptorsinstance ofExcitotoxicity is when nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters0.80text
NMDA receptors or AMPA receptors encounter excessive levels of the excitatory neurotransmitter glutamateinstance ofwhen glutamate receptors0.80text
significant neuronal damage might ensueinstance ofwhen glutamate receptors0.80text
calpaininstance ofand proteases0.80text
components of the cytoskeletoninstance ofThese enzymes go on to damage cell structures0.80text
membraneinstance ofThese enzymes go on to damage cell structures0.80text
and DNAinstance ofThese enzymes go on to damage cell structures0.80text
biological life it must be understood that mechanisms are rarelyinstance ofcomplex adaptive systems0.80text
if everinstance ofcomplex adaptive systems0.80text
simplistically directinstance ofcomplex adaptive systems0.80text
multiple sclerosisinstance ofand in neurodegenerative diseases of the central nervous system0.80text

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