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Ligand-gated ion channel: Ionotropic glutamate receptors, Overview & Cys-loop receptors

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

Language: English [EN]
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Ligand-gated ion channel topic overview

The analysis highlights Ionotropic glutamate receptors, Overview and Cys-loop receptors as prominent areas in the source structure around Ligand-gated ion channel.

Related topics
101
Source areas
5
Connected nodes
106
Extracted relationships
44
Related term clusters
37
Bridge connections
106

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ionotropic glutamate receptors · 55 topics
Overview · 24 topics
Clinical relevance · 10 topics
Cys-loop receptors · 10 topics
ATP-gated channels · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR006029 · PF02932
Available protein structures:
IPR006029 · PF02932
InterPro
IPR006029
OPM protein
2bg9
OPM superfamily
14
PDB
IPR006029 PF02932 (ECOD; PDBsum)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Cys-loop receptors

Ionotropic glutamate receptors

ATP-gated channels

Clinical relevance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Ligand-gated ion channel connects Entity context

The extracted context around Ligand-gated ion channel shows recurring relationship patterns in the source. For example, Ligand-gated ion channel → AMPA, Ca2, D-serine, Ligands, Mg2, N-methyl-D-aspartate, Na, NMDA, Studies, The N-methyl-D-aspartate, Thus, Zn2 Another extracted example is Ligand-gated ion channel → Agomelatine, Alzheimer's, Care Excellence, European Medicines Agency, FDA, GABA, Health, Ligand-gated, Memantine, NMDA, UK's National Institute. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ligand-gated ion channel

Top relations

related to NMDA receptors · 12
Ligand-gated ion channel → AMPA, Ca2, D-serine, Ligands, Mg2, N-methyl-D-aspartate, Na, NMDA, Studies, The N-methyl-D-aspartate, Thus, Zn2
related to Clinical relevance · 11
Ligand-gated ion channel → Agomelatine, Alzheimer's, Care Excellence, European Medicines Agency, FDA, GABA, Health, Ligand-gated, Memantine, NMDA, UK's National Institute
related to Cys-loop receptors · 6
Ligand-gated ion channel → AcCh, GABA, N-terminal, Na, Pro-loop, T2
AlphaFold · 2
Ligand-gated ion channel → IPR006029, PF02932
Available protein structures: · 2
Ligand-gated ion channel → IPR006029, PF02932
InterPro · 1
Ligand-gated ion channel → IPR006029
OPM protein · 1
Ligand-gated ion channel → 2bg9
OPM superfamily · 1
Ligand-gated ion channel → 14
PDB · 1
Ligand-gated ion channel → IPR006029 PF02932 (ECOD; PDBsum)
Pfam · 1
Ligand-gated ion channel → PF02932

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptors ion receptor channel glutamate channels ligand-gated nmda binding domain neurotransmitter transmembrane ionotropic extracellular ions ampa loop ligand two membrane

Ligand-gated ion channel relationships Subject–Predicate–Object triples

TTTA extracted 44 structured relationships around Ligand-gated ion channel. Examples in this analysis include Ligand-gated ion channel → AlphaFold → IPR006029 and Ligand-gated ion channel → AlphaFold → PF02932. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Ligand-gated ion channelAlphaFoldIPR0060291.00infobox
Ligand-gated ion channelAlphaFoldPF029321.00infobox
Ligand-gated ion channelAvailable protein structures:IPR0060291.00infobox
Ligand-gated ion channelAvailable protein structures:PF029321.00infobox
Ligand-gated ion channelInterProIPR0060291.00infobox
Ligand-gated ion channelOPM protein2bg91.00infobox
Ligand-gated ion channelOPM superfamily141.00infobox
Ligand-gated ion channelPDBIPR006029 PF02932 (ECOD; PDBsum)1.00infobox
Ligand-gated ion channelPfamPF029321.00infobox
Ligand-gated ion channelPROSITEPDOC002091.00infobox
Ligand-gated ion channelSCOP21cek / SCOPe / SUPFAM1.00infobox
Ligand-gated ion channelSymbolNeur_chan_memb1.00infobox
Ligand-gated ion channelTCDB1.A.91.00infobox
Ligand-gated ion channelis anicotinic acetylcholine receptor0.90text

Related concept clusters Related term clusters

The concept neighborhoods around Ligand-gated ion channel bring nearby vocabulary together. In this analysis, examples include Ligand-gated, Ion and Channels. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ligand-gated ion channel
    • Ligand-gated
    • Ion
    • Channels
    • Channel
    • Receptor
    • Receptors
    • Clinical
    • Membrane
    • Ionotropic
    • Ions
    • Neurotransmitter
    • Domain
  • ligand-gated ion channel
    • Ligand-gated
    • Channel
    • Ion
    • Receptor
    • Channels
    • Receptors
    • Binding
    • Ligand
    • Loop
    • Nmda
    • Potential
    • Extracellular
  • channel blockers
    • Ion
    • Receptor
    • Ligand-gated
    • Loop
    • Nmda
    • Potential
    • Glutamate
    • Pore
    • Ampa
    • Two
    • Extracellular
    • Acetylcholine
  • cys-loop receptors
    • Ionotropic
    • Cys-loop
    • Receptors
    • Neurotransmitter
    • Extracellular
    • Loop
    • Nmda
    • Domain
    • Lics
    • Postsynaptic
    • Clinical
    • Glutamate
  • ionotropic glutamate receptors
    • Glutamate
    • Ionotropic
    • Ampa
    • Lics
    • Acid
    • Cys-loop
    • Ligand-gated
    • Neurotransmitter
    • Receptors
    • Receptor
    • Nmda
    • Postsynaptic
  • atp-gated channels
    • Ligand-gated
    • Ion
    • Receptors
    • Membrane
    • Ionotropic
    • Ions
    • Lics
    • Response
    • Cys-loop
    • Flow
    • Na
    • Also
  • nicotinic acetylcholine receptor
    • Channel
    • Nmda
    • Ampa
    • Glutamate
    • Extracellular
    • Binding
    • Site
    • Two
    • Helices
    • Pore
    • Domain
    • Ions
  • ionotropic glutamate receptor
    • Glutamate
    • Ionotropic
    • Channel
    • Ampa
    • Nmda
    • Lics
    • Acid
    • Cys-loop
    • Ligand-gated
    • Receptors
    • Neurotransmitter
    • Receptor

Connections between topic areas Semantic bridges

For Ligand-gated ion channel, one of the stronger structural bridges in this analysis connects Ligand-gated ion channel with Ionotropic glutamate receptors. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Ligand-gated ion channel — Ionotropic glutamate receptors · splits 51 ⟂ 56
Ligand-gated ion channel — Overview · splits 82 ⟂ 25
Ligand-gated ion channel — Cys-loop receptors · splits 96 ⟂ 11
Ligand-gated ion channel — Clinical relevance · splits 96 ⟂ 11
Ligand-gated ion channel — ATP-gated channels · splits 104 ⟂ 3

Map overview Semantic statistics

Ligand-gated ion channel

Nodes107
Edges106
Triples44
Avg. degree1.98
Density0.018692
Components1

Source & methodology

TTTA analyzes the structure around Ligand-gated ion channel to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Ionotropic glutamate receptors, Overview & Cys-loop receptors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ligand-gated ion channel · EN edition · Analysis: TopicsToTalkAbout

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