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Ligand-gated ion channel: Ionotropic glutamate receptors, Overview & Cys-loop receptors
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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Ligand-gated ion channel topic overview
The analysis highlights Ionotropic glutamate receptors, Overview and Cys-loop receptors as prominent areas in the source structure around Ligand-gated ion channel.
Related topics
101
Source areas
5
Connected nodes
106
Extracted relationships
80
Concept neighborhoods
37
Bridge connections
106
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Ionotropic glutamate receptors · 55 topics
Overview · 24 topics
Clinical relevance · 10 topics
Cys-loop receptors · 10 topics
ATP-gated channels · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
AlphaFold
IPR006029 · PF02932
Available protein structures:
IPR006029 · PF02932
InterPro
IPR006029
OPM protein
2bg9
OPM superfamily
14
PDB
IPR006029 PF02932 (ECOD; PDBsum)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Ligand-gated ion channel connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Ligand-gated ion channel shows recurring relationship patterns in the source. For example, Ligand-gated ion channel → All, April, Archived, As, Basic, Clinical Pharmacology, Creative Commons Attribution-ShareAlike, Cys, European Bioinformatics Institute, Family, GFDL, International Union, Ion Channels, IUPHAR Database, LIC, Ligand-Gated Ion Channels, Nomenclature, Receptors, Revised Recommendations, The Neurotransmitter Receptor Another extracted example is Ligand-gated ion channel → AMPA, At, Ca2, D-serine, However, Ligands, Mg2, N-methyl-D-aspartate, Na, NMDA, Studies, The, The N-methyl-D-aspartate, Thus, When, Zn2. Use these groups to spot repeated connection types before inspecting the individual relationships.
Ligand-gated ion channel
Top relations
related to External links· 23
Ligand-gated ion channel → All, April, Archived, As, Basic, Clinical Pharmacology, Creative Commons Attribution-ShareAlike, Cys, European Bioinformatics Institute, Family, GFDL, International Union, Ion Channels, IUPHAR Database, LIC, Ligand-Gated Ion Channels, Nomenclature, Receptors, Revised Recommendations, The Neurotransmitter Receptor
related to NMDA receptors· 16
Ligand-gated ion channel → AMPA, At, Ca2, D-serine, However, Ligands, Mg2, N-methyl-D-aspartate, Na, NMDA, Studies, The, The N-methyl-D-aspartate, Thus, When, Zn2
related to Clinical relevance· 13
Ligand-gated ion channel → Agomelatine, Alzheimer's, By, Care Excellence, European Medicines Agency, FDA, GABA, Health, In, Ligand-gated, Memantine, NMDA, UK's National Institute
related to Cys-loop receptors· 13
Ligand-gated ion channel → AcCh, GABA, It, N-terminal, Na, Pro-loop, Some, T2, The, They, This, When, With
AlphaFold· 2
Ligand-gated ion channel → IPR006029, PF02932
Available protein structures:· 2
Ligand-gated ion channel → IPR006029, PF02932
InterPro· 1
Ligand-gated ion channel → IPR006029
OPM protein· 1
Ligand-gated ion channel → 2bg9
OPM superfamily· 1
Ligand-gated ion channel → 14
PDB· 1
Ligand-gated ion channel → IPR006029 PF02932 (ECOD; PDBsum)
Important terminology
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Ligand-gated ion channel relationships Subject–Predicate–Object triples
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 80 structured relationships around Ligand-gated ion channel. Examples in this analysis include Ligand-gated ion channel → AlphaFold → IPR006029 and Ligand-gated ion channel → AlphaFold → PF02932. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Ligand-gated ion channel
AlphaFold
IPR006029
1.00
infobox
Ligand-gated ion channel
AlphaFold
PF02932
1.00
infobox
Ligand-gated ion channel
Available protein structures:
IPR006029
1.00
infobox
Ligand-gated ion channel
Available protein structures:
PF02932
1.00
infobox
Ligand-gated ion channel
InterPro
IPR006029
1.00
infobox
Ligand-gated ion channel
OPM protein
2bg9
1.00
infobox
Ligand-gated ion channel
OPM superfamily
14
1.00
infobox
Ligand-gated ion channel
PDB
IPR006029 PF02932 (ECOD; PDBsum)
1.00
infobox
Ligand-gated ion channel
Pfam
PF02932
1.00
infobox
Ligand-gated ion channel
PROSITE
PDOC00209
1.00
infobox
Ligand-gated ion channel
SCOP2
1cek / SCOPe / SUPFAM
1.00
infobox
Ligand-gated ion channel
Symbol
Neur_chan_memb
1.00
infobox
Ligand-gated ion channel
TCDB
1.A.9
1.00
infobox
Ligand-gated ion channel
is a
nicotinic acetylcholine receptor
0.90
text
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Ligand-gated ion channel bring nearby vocabulary together. In this analysis, examples include Ligand-gated, Ion and Channels. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Ligand-gated ion channel
Ligand-gated
Ion
Channels
Channel
Receptor
Receptors
Clinical
Membrane
Ionotropic
Ions
Neurotransmitter
Domain
ligand-gated ion channel
Ligand-gated
Channel
Ion
Receptor
Channels
Receptors
Binding
Ligand
Loop
Nmda
Potential
Extracellular
channel blockers
Ion
Receptor
Ligand-gated
Loop
Nmda
Potential
Glutamate
Pore
Ampa
Two
Extracellular
Acetylcholine
cys-loop receptors
Ionotropic
Cys-loop
Receptors
Neurotransmitter
Extracellular
Loop
Nmda
Domain
Lics
Postsynaptic
Clinical
Glutamate
ionotropic glutamate receptors
Glutamate
Ionotropic
Ampa
Lics
Acid
Cys-loop
Ligand-gated
Neurotransmitter
Receptors
Receptor
Nmda
Postsynaptic
atp-gated channels
Ligand-gated
Ion
Receptors
Membrane
Ionotropic
Ions
Lics
Response
Cys-loop
Flow
Na
Also
nicotinic acetylcholine receptor
Channel
Nmda
Ampa
Glutamate
Extracellular
Binding
Site
Two
Helices
Pore
Domain
Ions
ionotropic glutamate receptor
Glutamate
Ionotropic
Channel
Ampa
Nmda
Lics
Acid
Cys-loop
Ligand-gated
Receptors
Neurotransmitter
Receptor
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Ligand-gated ion channel, one of the stronger structural bridges in this analysis connects Ligand-gated ion channel with Ionotropic glutamate receptors. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Min side: 3
Ligand-gated ion channel — Ionotropic glutamate receptors· splits 51 ⟂ 56Ligand-gated ion channel — Overview· splits 82 ⟂ 25Ligand-gated ion channel — Cys-loop receptors· splits 96 ⟂ 11Ligand-gated ion channel — Clinical relevance· splits 96 ⟂ 11Ligand-gated ion channel — ATP-gated channels· splits 104 ⟂ 3
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Ligand-gated ion channel
Nodes107
Edges106
Triples80
Avg. degree1.98
Density0.018692
Components1
Source & methodology
TTTA analyzes the structure around Ligand-gated ion channel to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Ionotropic glutamate receptors, Overview & Cys-loop receptors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
