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Phosphofructokinase: Function, Clinical significance & Overview

Phosphofructokinase (PFK) is a kinase enzyme that phosphorylates fructose 6-phosphate in glycolysis.

Language: English [EN]
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Phosphofructokinase topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around Phosphofructokinase.

Related topics
37
Source areas
3
Connected nodes
40
Extracted relationships
39
Concept neighborhoods
19
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 32 topics
Overview · 4 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR000023 · PF00365
Available protein structures:
IPR000023 · PF00365
InterPro
IPR000023
PDB
PDB: 1kzh​ PDB: 1mto​ PDB: 1pfk​ PDB: 3pfk​ PDB: 4pfk​ PDB: 6pfk​ IPR000023 PF00365 (ECOD; PDBsum)
Pfam
PF00365
PROSITE
PDOC00336

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Phosphofructokinase connects Entity context

The extracted context around Phosphofructokinase shows recurring relationship patterns in the source. For example, Phosphofructokinase → AK, It, Other, PFK, PfkB, PfkB/RK, PFKL, PFKM, PFKP, Ribokinase, RK, The Another extracted example is Phosphofructokinase → ADP, AMP, ATP, It, PFK, PFK1, PFK2, The, These, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Phosphofructokinase

Top relations

related to Phosphofructokinase family · 12
Phosphofructokinase → AK, It, Other, PFK, PfkB, PfkB/RK, PFKL, PFKM, PFKP, Ribokinase, RK, The
related to Function · 10
Phosphofructokinase → ADP, AMP, ATP, It, PFK, PFK1, PFK2, The, These, This
related to External links · 4
Phosphofructokinase → Medicine Medical Subject Headings, MeSH, National Library, Phosphofructokinases
see also · 3
Phosphofructokinase → GSD, Tarui's, VII
AlphaFold · 2
Phosphofructokinase → IPR000023, PF00365
Available protein structures: · 2
Phosphofructokinase → IPR000023, PF00365
InterPro · 1
Phosphofructokinase → IPR000023
PDB · 1
Phosphofructokinase → PDB: 1kzh​ PDB: 1mto​ PDB: 1pfk​ PDB: 3pfk​ PDB: 4pfk​ PDB: 6pfk​ IPR000023 PF00365 (ECOD; PDBsum)
Pfam · 1
Phosphofructokinase → PF00365
PROSITE · 1
Phosphofructokinase → PDOC00336

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pfk family enzyme glycolytic atp protein kinase reaction fructose-1 pathway activity function regulation also conformations structures phosphorylates glycolysis phosphoryl 6-bisphosphate

Phosphofructokinase relationships Subject–Predicate–Object triples

TTTA extracted 39 structured relationships around Phosphofructokinase. Examples in this analysis include Phosphofructokinase → AlphaFold → IPR000023 and Phosphofructokinase → AlphaFold → PF00365. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PhosphofructokinaseAlphaFoldIPR0000231.00infobox
PhosphofructokinaseAlphaFoldPF003651.00infobox
PhosphofructokinaseAvailable protein structures:IPR0000231.00infobox
PhosphofructokinaseAvailable protein structures:PF003651.00infobox
PhosphofructokinaseInterProIPR0000231.00infobox
PhosphofructokinasePDBPDB: 1kzh​ PDB: 1mto​ PDB: 1pfk​ PDB: 3pfk​ PDB: 4pfk​ PDB: 6pfk​ IPR000023 PF00365 (ECOD; PDBsum)1.00infobox
PhosphofructokinasePfamPF003651.00infobox
PhosphofructokinasePROSITEPDOC003361.00infobox
PhosphofructokinaseSymbolPpfruckinase1.00infobox
Phosphofructokinaserelated to External linksPhosphofructokinases0.60section
Phosphofructokinaserelated to External linksNational Library0.60section
Phosphofructokinaserelated to External linksMedicine Medical Subject Headings0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Phosphofructokinase bring nearby vocabulary together. In this analysis, examples include Fructose-1, Reaction and Family. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Phosphofructokinase
    • Fructose-1
    • Reaction
    • Family
    • Glycolysis
    • Phosphorylates
    • 6-bisphosphate
    • Also
    • Deficiency
    • Different
    • Function
    • Humans
    • Pfkb
  • phosphofructokinase
    • Fructose-1
    • Reaction
    • Family
    • Glycolysis
    • Phosphorylates
    • 6-bisphosphate
    • Also
    • Deficiency
    • Different
    • Function
    • Humans
    • Pfkb
  • bacterial enzyme
    • Fructose-1
    • Pfk
    • Phosphofructokinase
    • Glycolysis
    • Phosphorylates
    • 6-bisphosphate
    • Allosteric
    • Conformations
    • Different
    • Kinase
    • Pfkb
    • Phosphoryl
  • atp
    • Allosteric
    • Function
    • Phosphoryl
    • Regulation
    • Regulatory
    • Similar
    • Structures
    • Two
    • Activity
    • Pathway
    • Protein
    • Reaction
  • function
    • Also
    • Found
    • Muscle
    • Pfkl
    • Phosphoryl
    • Regulation
    • Structures
    • Tissue-specific
    • Atp
    • Protein
    • Reaction
    • Family
  • fructose-1,6-bisphosphate
    • 6-bisphosphate
    • Fructose-1
    • Conformations
    • Different
    • Phosphofructokinase
    • Phosphoryl
    • Regulatory
    • Pathway
    • Pfkb
    • Enzyme
    • Glycolytic
    • Reaction
  • enzymatic activity
    • Allosteric
    • Pfk
    • Presence
    • Regulatory
    • Similar
    • Structures
    • Two
    • Atp
    • Protein
    • Enzyme
    • Family
  • glycolytic pathway
    • Pathway
    • Conformations
    • Regulatory
    • Found
    • Humans
    • May
    • Pfkl
    • Reaction
    • Tissue-specific
    • Phosphofructokinase

Connections between topic areas Semantic bridges

For Phosphofructokinase, one of the stronger structural bridges in this analysis connects Phosphofructokinase with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PhosphofructokinaseFunction · splits 8 ⟂ 33
PhosphofructokinaseOverview · splits 36 ⟂ 5

Map overview Semantic statistics

Phosphofructokinase

Nodes41
Edges40
Triples39
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around Phosphofructokinase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Phosphofructokinase · EN edition · Analysis: TopicsToTalkAbout

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