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IL1RL1: Regions, Regulatory T cells & Function

Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene.

Language: English [EN]
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IL1RL1 topic overview

The analysis highlights Regions, Regulatory T cells and Function as prominent areas in the source structure around IL1RL1.

Related topics
25
Source areas
5
Connected nodes
30
Extracted relationships
120
Concept neighborhoods
15
Bridge connections
30

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Regulatory T cells · 12 topics
Function · 4 topics
Molecular biology · 4 topics
Clinical significance · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.2.2.6
Aliases
IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, interleukin 1 receptor like 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KC3
Band
2q12.1 · 1 B|1 19.19 cM
Bgee
upper lobe of left lung · decidua · right lung · cartilage tissue · lower lobe of lung
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Molecular biology

Regulatory T cells

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How IL1RL1 connects Entity context

The extracted context around IL1RL1 shows recurring relationship patterns in the source. For example, IL1RL1 → body of stomach, cartilage tissue, decidua, duodenum, embryo, endothelial cell of lymphatic vessel, esophagus, granulocyte, human kidney, ileum, jejunum, lactiferous gland, left adrenal cortex, left adrenal gland, lip, lower lobe of lung, muscle of thigh, right adrenal gland, right lung, upper lobe of left lung Another extracted example is IL1RL1 → cytokine receptor activity, external side of plasma membrane, extracellular matrix, extracellular region, immune response, integral component of membrane, interleukin-1 receptor activity, interleukin-33 binding, interleukin-33 receptor activity, interleukin-33-mediated signaling pathway, membrane, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of interferon-gamma production, negative regulation of T-helper 1 type immune response, plasma membrane, positive regulation of inflammatory response, positive regulation of interleukin-5 production, positive regulation of macrophage activation, protein binding, signal transduction. Use these groups to spot repeated connection types before inspecting the individual relationships.

IL1RL1

Top relations

Bgee · 20
IL1RL1 → body of stomach, cartilage tissue, decidua, duodenum, embryo, endothelial cell of lymphatic vessel, esophagus, granulocyte, human kidney, ileum, jejunum, lactiferous gland, left adrenal cortex, left adrenal gland, lip, lower lobe of lung, muscle of thigh, right adrenal gland, right lung, upper lobe of left lung
Gene ontology · 20
IL1RL1 → cytokine receptor activity, external side of plasma membrane, extracellular matrix, extracellular region, immune response, integral component of membrane, interleukin-1 receptor activity, interleukin-33 binding, interleukin-33 receptor activity, interleukin-33-mediated signaling pathway, membrane, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of interferon-gamma production, negative regulation of T-helper 1 type immune response, plasma membrane, positive regulation of inflammatory response, positive regulation of interleukin-5 production, positive regulation of macrophage activation, protein binding, signal transduction
RNA expression pattern · 20
IL1RL1 → body of stomach, cartilage tissue, decidua, duodenum, embryo, endothelial cell of lymphatic vessel, esophagus, granulocyte, human kidney, ileum, jejunum, lactiferous gland, left adrenal cortex, left adrenal gland, lip, lower lobe of lung, muscle of thigh, right adrenal gland, right lung, upper lobe of left lung
related to Regulatory T cells · 19
IL1RL1 → Activation, Alarmin IL-33, Human, IFNg, IL-1, Il-33, IL-33/ST2, IL1RAcP, In, Interestingly, MyD88, Releasing, ST2, The, This, TIR, Toll/IL-1, TRAF6, Two
related to Function · 15
IL1RL1 → As, Binding, IL-33, Interleukin-33, MAP, NF-κB, ST2, ST2L, The, The ST2, This, TIR, Toll-like, Unlike, When
Band · 2
IL1RL1 → 1 B|1 19.19 cM, 2q12.1
Chr. · 2
IL1RL1 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
IL1RL1 → 102,352,037 bp, 40,504,575 bp
3.2.2.6 · 1
IL1RL1 → ↗
Aliases · 1
IL1RL1 → IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, interleukin 1 receptor like 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

st2 il-33 gene receptor function protein soluble bp regulatory cells human activation chr band chromosome il-1 expression cell cytokine also

IL1RL1 relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around IL1RL1. Examples in this analysis include IL1RL1 → 3.2.2.6 → ↗ and IL1RL1 → Aliases → IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, interleukin 1 receptor like 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IL1RL13.2.2.61.00infobox
IL1RL1AliasesIL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, interleukin 1 receptor like 11.00infobox
IL1RL1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KC31.00infobox
IL1RL1Band2q12.11.00infobox
IL1RL1Band1 B|1 19.19 cM1.00infobox
IL1RL1Bgeeupper lobe of left lung1.00infobox
IL1RL1Bgeedecidua1.00infobox
IL1RL1Bgeeright lung1.00infobox
IL1RL1Bgeecartilage tissue1.00infobox
IL1RL1Bgeelower lobe of lung1.00infobox
IL1RL1Bgeeleft adrenal gland1.00infobox
IL1RL1Bgeeleft adrenal cortex1.00infobox
IL1RL1Bgeeright adrenal gland1.00infobox
IL1RL1Bgeehuman kidney1.00infobox
IL1RL1Bgeebody of stomach1.00infobox
IL1RL1Bgeeendothelial cell of lymphatic vessel1.00infobox
IL1RL1Bgeegranulocyte1.00infobox
IL1RL1Bgeeembryo1.00infobox
IL1RL1Bgeeduodenum1.00infobox
IL1RL1Bgeelip1.00infobox
IL1RL1Bgeeileum1.00infobox
IL1RL1Bgeejejunum1.00infobox
IL1RL1Bgeemuscle of thigh1.00infobox
IL1RL1Bgeeesophagus1.00infobox
IL1RL1Bgeelactiferous gland1.00infobox
IL1RL1BioGPSMore reference expression data1.00infobox
IL1RL1Chr.Chromosome 2 (human)1.00infobox
IL1RL1Chr.Chromosome 1 (mouse)1.00infobox
IL1RL1DatabasesNCBI: entry; OMA: entry1.00infobox
IL1RL1End102,352,037 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around IL1RL1 bring nearby vocabulary together. In this analysis, examples include Region, Activation and Interleukin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • IL1RL1
    • Region
    • Activation
    • Interleukin
    • Location
    • Molecular
    • Gene
    • Bp
    • Chr
    • Chromosome
    • Human
    • Function
    • Protein
  • il1rl1
    • Region
    • Activation
    • Interleukin
    • Location
    • Molecular
    • Gene
    • Bp
    • Chr
    • Chromosome
    • Human
    • Function
    • Protein
  • protein
    • Endothelial
    • Molecular
    • Human
    • Receptor
    • Extracellular
    • Mouse
    • Region
    • Binding
    • Immune
    • Isoforms
    • Location
    • Membrane
  • gene
    • Chromosome
    • Il1rl1
    • Location
    • Bp
    • Chr
    • Expression
    • Human
    • St2
    • Function
    • Protein
    • Mouse
    • Region
  • t regulatory cells
    • Regulatory
    • Cell
    • Function
    • Immune
    • Presence
    • Il-1
    • Il-33
    • Receptor
    • St2
    • Endothelial
    • Foxp3
    • Gata3
  • function
    • Cells
    • Regulatory
    • Binding
    • Location
    • Molecular
    • Receptor
    • Effect
    • Bp
    • Cell
    • Chr
    • Chromosome
    • Cytokine
  • regulatory t cells
    • Regulatory
    • Cell
    • Function
    • Immune
    • Presence
    • Il-1
    • Il-33
    • Receptor
    • St2
    • Endothelial
    • Foxp3
    • Gata3
  • toll-like receptor
    • Domain
    • St2
    • Binding
    • Il-1
    • Il-33
    • Activation
    • Regulatory
    • Soluble
    • Extracellular
    • Mouse
    • Region
    • Endothelial

Connections between topic areas Semantic bridges

For IL1RL1, one of the stronger structural bridges in this analysis connects IL1RL1 with Regulatory T cells. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IL1RL1Regulatory T cells · splits 18 ⟂ 13
IL1RL1Function · splits 26 ⟂ 5
IL1RL1Molecular biology · splits 26 ⟂ 5
IL1RL1Clinical significance · splits 27 ⟂ 4
IL1RL1Overview · splits 28 ⟂ 3

Map overview Semantic statistics

IL1RL1

Nodes31
Edges30
Triples120
Avg. degree1.94
Density0.064516
Components1

Source & methodology

TTTA analyzes the structure around IL1RL1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Regulatory T cells & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IL1RL1 · EN edition · Analysis: TopicsToTalkAbout

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