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Integrin beta 6

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins which span the cell's membrane, integrating the outside and inside of the cell. Integrins bind to specific extracellular proteins in the extracellular matrix or on other cells and subsequently…

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Integrin αvβ6 as a drug target

CarcinomasSingle-photon emission computed tomography (SPECT)ScintigraphyRadiopharmaceuticalsPeptide
14 related topics

Clinical significance

FibrosisCollagenFibroblastsBreast cancerLung cancer
9 related topics

Discovery

STAT3C/EBPαEts-1Smad3EIF4E
5 related topics

Interactions

InteractFHL2
2 related topics

Key facts & relationships

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Aliases
ITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM9
Band
2q24.2 · 2 C1.1- C1.2|2 34.81 cM
Bgee
visceral pleura · biceps brachii · Skeletal muscle tissue of rectus abdominis · Skeletal muscle tissue of biceps brachii · palpebral conjunctiva
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

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Overview

Discovery

Mouse models

Clinical significance

Integrin αvβ6 as a drug target

Interactions

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Map overview Semantic statistics

Integrin beta 6

Nodes48
Edges47
Triples108
Avg. degree1.96
Density0.041667
Components1

How this topic connects Entity context

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Integrin beta 6

Top relations

Gene ontology · 26
Integrin beta 6 → cell adhesion, cell adhesion mediated by integrin, cell junction, cell migration, cell surface, cell-matrix adhesion, centrosome, external side of plasma membrane, extracellular matrix organization, focal adhesion, inflammatory response, integral component of membrane, integrin alphav-beta6 complex, integrin binding, integrin complex, integrin-mediated signaling pathway, membrane, nucleoplasm, plasma membrane, protein binding
Bgee · 19
Integrin beta 6 → biceps brachii, body of tongue, digastric muscle, epithelium of stomach, extraocular muscle, human kidney, lactiferous duct, lower lobe of lung, muscle of thigh, palpebral conjunctiva, proximal tubule, right kidney, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, vastus lateralis muscle, visceral pleura
RNA expression pattern · 19
Integrin beta 6 → biceps brachii, body of tongue, digastric muscle, epithelium of stomach, extraocular muscle, human kidney, lactiferous duct, lower lobe of lung, muscle of thigh, palpebral conjunctiva, proximal tubule, right kidney, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, vastus lateralis muscle, visceral pleura
Band · 2
Integrin beta 6 → 2 C1.1- C1.2|2 34.81 cM, 2q24.2
Chr. · 2
Integrin beta 6 → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Integrin beta 6 → 160,200,313 bp, 60,552,987 bp
related to Interactions · 2
Integrin beta 6 → FHL2, Integrin
Aliases · 1
Integrin beta 6 → ITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6
Available structures · 1
Integrin beta 6 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM9
BioGPS · 1
Integrin beta 6 → More reference expression data

Important terminology Word statistics

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Important terminology

itgb6 αvβ6 cells integrin cancer cell found expression mice fibrosis tgf-β1 matrix bp also subunit αvβ6-integrin gene tissue chr mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Integrin beta 6AliasesITGB6, AI1H, Integrin, beta 6, integrin subunit beta 61.00infobox
Integrin beta 6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM91.00infobox
Integrin beta 6Band2q24.21.00infobox
Integrin beta 6Band2 C1.1- C1.2|2 34.81 cM1.00infobox
Integrin beta 6Bgeevisceral pleura1.00infobox
Integrin beta 6Bgeebiceps brachii1.00infobox
Integrin beta 6BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
Integrin beta 6BgeeSkeletal muscle tissue of biceps brachii1.00infobox
Integrin beta 6Bgeepalpebral conjunctiva1.00infobox
Integrin beta 6Bgeelower lobe of lung1.00infobox
Integrin beta 6Bgeevastus lateralis muscle1.00infobox
Integrin beta 6Bgeebody of tongue1.00infobox
Integrin beta 6Bgeemuscle of thigh1.00infobox
Integrin beta 6Bgeelactiferous duct1.00infobox
Integrin beta 6Bgeeright kidney1.00infobox
Integrin beta 6Bgeeproximal tubule1.00infobox
Integrin beta 6Bgeeepithelium of stomach1.00infobox
Integrin beta 6Bgeetriceps brachii muscle1.00infobox
Integrin beta 6Bgeeextraocular muscle1.00infobox
Integrin beta 6Bgeehuman kidney1.00infobox
Integrin beta 6Bgeesternocleidomastoid muscle1.00infobox
Integrin beta 6Bgeetemporal muscle1.00infobox
Integrin beta 6Bgeedigastric muscle1.00infobox
Integrin beta 6BioGPSMore reference expression data1.00infobox
Integrin beta 6Chr.Chromosome 2 (human)1.00infobox
Integrin beta 6Chr.Chromosome 2 (mouse)1.00infobox
Integrin beta 6DatabasesNCBI: entry; OMA: entry1.00infobox
Integrin beta 6End160,200,313 bp1.00infobox
Integrin beta 6End60,552,987 bp1.00infobox
Integrin beta 6EnsemblENSG000001152211.00infobox

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