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Integrin beta 6: Applications & Measurement

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins which span the cell's membrane, integrating the outside and inside of the cell. Integrins bind to specific extracellular proteins in the extracellular matrix or on other cells and subsequently…

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Integrin beta 6 topic overview

The analysis highlights Applications and Measurement as prominent areas in the source structure around Integrin beta 6.

Related topics
41
Source areas
6
Connected nodes
47
Extracted relationships
108
Related term clusters
16
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Integrin αvβ6 as a drug target · 14 topics
Overview · 10 topics
Clinical significance · 9 topics
Discovery · 5 topics
Interactions · 2 topics
Mouse models · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM9
Band
2q24.2 · 2 C1.1- C1.2|2 34.81 cM
Bgee
visceral pleura · biceps brachii · Skeletal muscle tissue of rectus abdominis · Skeletal muscle tissue of biceps brachii · palpebral conjunctiva
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Mouse models

Clinical significance

Integrin αvβ6 as a drug target

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Integrin beta 6 connects Entity context

The extracted context around Integrin beta 6 shows recurring relationship patterns in the source. For example, Integrin beta 6 → cell adhesion, cell adhesion mediated by integrin, cell junction, cell migration, cell surface, cell-matrix adhesion, centrosome, external side of plasma membrane, extracellular matrix organization, focal adhesion, inflammatory response, integral component of membrane, integrin alphav-beta6 complex, integrin binding, integrin complex, integrin-mediated signaling pathway, membrane, nucleoplasm, plasma membrane, protein binding Another extracted example is Integrin beta 6 → biceps brachii, body of tongue, digastric muscle, epithelium of stomach, extraocular muscle, human kidney, lactiferous duct, lower lobe of lung, muscle of thigh, palpebral conjunctiva, proximal tubule, right kidney, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, vastus lateralis muscle, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Integrin beta 6

Top relations

Gene ontology · 26
Integrin beta 6 → cell adhesion, cell adhesion mediated by integrin, cell junction, cell migration, cell surface, cell-matrix adhesion, centrosome, external side of plasma membrane, extracellular matrix organization, focal adhesion, inflammatory response, integral component of membrane, integrin alphav-beta6 complex, integrin binding, integrin complex, integrin-mediated signaling pathway, membrane, nucleoplasm, plasma membrane, protein binding
Bgee · 19
Integrin beta 6 → biceps brachii, body of tongue, digastric muscle, epithelium of stomach, extraocular muscle, human kidney, lactiferous duct, lower lobe of lung, muscle of thigh, palpebral conjunctiva, proximal tubule, right kidney, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, vastus lateralis muscle, visceral pleura
RNA expression pattern · 19
Integrin beta 6 → biceps brachii, body of tongue, digastric muscle, epithelium of stomach, extraocular muscle, human kidney, lactiferous duct, lower lobe of lung, muscle of thigh, palpebral conjunctiva, proximal tubule, right kidney, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, triceps brachii muscle, vastus lateralis muscle, visceral pleura
Band · 2
Integrin beta 6 → 2 C1.1- C1.2|2 34.81 cM, 2q24.2
Chr. · 2
Integrin beta 6 → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Integrin beta 6 → 160,200,313 bp, 60,552,987 bp
related to Interactions · 2
Integrin beta 6 → FHL2, Integrin
Aliases · 1
Integrin beta 6 → ITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6
Available structures · 1
Integrin beta 6 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM9
BioGPS · 1
Integrin beta 6 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

itgb6 αvβ6 cells integrin cancer cell found expression mice fibrosis tgf-β1 matrix bp also subunit αvβ6-integrin gene tissue chr mouse

Integrin beta 6 relationships Subject–Predicate–Object triples

TTTA extracted 108 structured relationships around Integrin beta 6. Examples in this analysis include Integrin beta 6 → Aliases → ITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6 and Integrin beta 6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM9. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Integrin beta 6AliasesITGB6, AI1H, Integrin, beta 6, integrin subunit beta 61.00infobox
Integrin beta 6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UM8, 4UM91.00infobox
Integrin beta 6Band2q24.21.00infobox
Integrin beta 6Band2 C1.1- C1.2|2 34.81 cM1.00infobox
Integrin beta 6Bgeevisceral pleura1.00infobox
Integrin beta 6Bgeebiceps brachii1.00infobox
Integrin beta 6BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
Integrin beta 6BgeeSkeletal muscle tissue of biceps brachii1.00infobox
Integrin beta 6Bgeepalpebral conjunctiva1.00infobox
Integrin beta 6Bgeelower lobe of lung1.00infobox
Integrin beta 6Bgeevastus lateralis muscle1.00infobox
Integrin beta 6Bgeebody of tongue1.00infobox
Integrin beta 6Bgeemuscle of thigh1.00infobox
Integrin beta 6Bgeelactiferous duct1.00infobox
Integrin beta 6Bgeeright kidney1.00infobox
Integrin beta 6Bgeeproximal tubule1.00infobox
Integrin beta 6Bgeeepithelium of stomach1.00infobox
Integrin beta 6Bgeetriceps brachii muscle1.00infobox
Integrin beta 6Bgeeextraocular muscle1.00infobox
Integrin beta 6Bgeehuman kidney1.00infobox
Integrin beta 6Bgeesternocleidomastoid muscle1.00infobox
Integrin beta 6Bgeetemporal muscle1.00infobox
Integrin beta 6Bgeedigastric muscle1.00infobox
Integrin beta 6BioGPSMore reference expression data1.00infobox
Integrin beta 6Chr.Chromosome 2 (human)1.00infobox
Integrin beta 6Chr.Chromosome 2 (mouse)1.00infobox
Integrin beta 6DatabasesNCBI: entry; OMA: entry1.00infobox
Integrin beta 6End160,200,313 bp1.00infobox
Integrin beta 6End60,552,987 bp1.00infobox
Integrin beta 6EnsemblENSG000001152211.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Integrin beta 6 bring nearby vocabulary together. In this analysis, examples include Subunit, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Integrin beta 6
    • Subunit
    • Function
    • Gene
    • Αvβ6
    • Human
    • Location
    • Multiple
    • Itgb6
    • Bp
    • Chr
    • Chromosome
    • Mouse
  • integrin beta 6
    • Subunit
    • Function
    • Gene
    • Αvβ6
    • Human
    • Location
    • Multiple
    • Itgb6
    • Bp
    • Chr
    • Chromosome
    • Mouse
  • gene
    • Location
    • Human
    • Bp
    • Chr
    • Chromosome
    • Mouse
    • Band
    • Function
    • Integrin
    • Subunit
    • Itgb6
    • Expression
  • cells
    • Found
    • Epithelial
    • Extracellular
    • Cancer
    • Normal
    • Tissue
    • Matrix
    • Expressed
    • Fibroblasts
    • High
    • Activation
    • Development
  • breast cancer
    • Fibrosis
    • Αvβ6
    • Cells
    • Expression
    • High
    • Development
    • Normal
    • Also
    • Cell
    • Found
    • Itgb6
    • Cancers
  • lung cancer
    • Tissue
    • Fibrosis
    • Αvβ6
    • Cells
    • Expression
    • High
    • Development
    • Normal
    • Fibroblasts
    • Also
    • Cell
    • Mouse
  • pancreatic cancer
    • Fibrosis
    • Αvβ6
    • Cells
    • Expression
    • High
    • Development
    • Normal
    • Also
    • Cell
    • Found
    • Itgb6
    • Cancers
  • integrin αvβ6 as a drug target
    • Subunit
    • Function
    • Gene
    • Αvβ6
    • Human
    • Location
    • Multiple
    • Itgb6
    • Bp
    • Chr
    • Chromosome
    • Mouse

Connections between topic areas Semantic bridges

For Integrin beta 6, one of the stronger structural bridges in this analysis connects Integrin beta 6 with Integrin αvβ6 as a drug target. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Integrin beta 6 — Integrin αvβ6 as a drug target · splits 33 ⟂ 15
Integrin beta 6 — Overview · splits 37 ⟂ 11
Integrin beta 6 — Clinical significance · splits 38 ⟂ 10
Integrin beta 6 — Discovery · splits 42 ⟂ 6
Integrin beta 6 — Interactions · splits 45 ⟂ 3

Map overview Semantic statistics

Integrin beta 6

Nodes48
Edges47
Triples108
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around Integrin beta 6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Integrin beta 6 · EN edition · Analysis: TopicsToTalkAbout

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