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Exosome complex

The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of RNA (ribonucleic acid) molecules. Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome carries out similar functions.

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Exosome complex

Nodes96
Edges95
Triples109
Avg. degree1.98
Density0.020833
Components1

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Exosome complex

Top relations

related to Autoimmunity · 20
Exosome complex → Already, Although, At, Autoantibodies, By, C1D, ELISA, ELISAs, HEp-2, Immunofluorescence, In, LIAs, More, PM/Scl, PM/Scl-100, PM/Scl-75, RNase, RNase PH, The, These
related to Regulatory proteins · 17
Exosome complex → Apart, ARE, AU-rich, C1D/Rrp47, In, KRSP, MPP6/Mpp6, Mtr4, One, RNA, Ski, Ski2, The, These, TRAMP, Trf4, TTP
related to Core proteins · 16
Exosome complex → Eukaryotic, In, K-homology, KH, Located, Of, PH-like, RBD, RNase PH-like, RNases, Rrp41, Rrp42, S1, S1 RNA, The, Two
related to Associated proteins · 14
Exosome complex → Besides, DIS3, DIS3L1, In, Like Rrp44, One, PM/Scl-100, RNA, RNase, Rrp44, Rrp6, The, These, While
related to Substrates · 13
Exosome complex → Although, AU-rich, Bacteria, Both, Finally, In, PNPase, RNA, RNAs, Several, The, There, When
related to Enzymatic function · 11
Exosome complex → As, Despite, Exoribonucleases, In, RNA, RNase, RNase PH, RNase PH-like, Rrp41, The, Three
related to Discovery · 7
Exosome complex → In, Not, PM/Scl, Purification, RNase, Saccharomyces, The
related to List of subunits · 6
Exosome complex → AIn, BIn, CContributes, Dis3, Dis3L1, In
is a · 1
Exosome complex → target of autoantibodies in patients with various autoimmune diseases

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Important terminology

exosome rna proteins complex protein cells activity rnase structure two pm nucleus complexes ring patients processing associated degradation core autoantibodies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Exosome complexis atarget of autoantibodies in patients with various autoimmune diseases0.90text
protein synthesis.In addition to RNA processinginstance ofIt is presumed that this system prevents aberrant complexes from interfering with important cellular processes0.80text
turnoverinstance ofIt is presumed that this system prevents aberrant complexes from interfering with important cellular processes0.80text
surveillance activitiesinstance ofIt is presumed that this system prevents aberrant complexes from interfering with important cellular processes0.80text
the exosome is important for the degradation of so-called cryptic unstable transcriptsinstance ofIt is presumed that this system prevents aberrant complexes from interfering with important cellular processes0.80text
Exosome complexrelated to Associated proteinsBesides0.60section
Exosome complexrelated to Associated proteinsOne0.60section
Exosome complexrelated to Associated proteinsRrp440.60section
Exosome complexrelated to Associated proteinsRNase0.60section
Exosome complexrelated to Associated proteinsIn0.60section
Exosome complexrelated to Associated proteinsWhile0.60section
Exosome complexrelated to Associated proteinsThese0.60section

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