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TRAMP complex

TRAMP complex (Trf4/Air2/Mtr4p Polyadenylation complex) is a multiprotein, heterotrimeric complex having distributive polyadenylation activity and identifies wide varieties of RNAs produced by polymerases. It was originally discovered in Saccharomyces cerevisiae by LaCava et al., Vanacova et al. and Wyers et al. in 2005. The analogous complex in humans…

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Components, In humans & Overview

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Overview

Components

Difference between canonical and non-canonical polymerases

Interaction with 3’->5’ exonuclease complex exosome

RNA substrates

Role in maintaining chromatin

Conservation of TRAMP-mediated processes

In humans

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TRAMP complex

Nodes41
Edges40
Triples114
Avg. degree1.95
Density0.04878
Components1

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TRAMP complex

Top relations

related to Ski2 like helicase Mtr4p · 21
TRAMP complex → Arch, ATP, DExH-box RNA, Dob1p, It, KOW, Kyprides, Mtr4p, Ouzounis, Poly, Q-motif, RecA, RNA, SF2, The, The Ski2, Through, TRAMP, WH, Winged Helix
related to Interaction with 3’->5’ exonuclease complex exosome · 19
TRAMP complex → Also, Mtr3p, RNA, RNAs, RNase PH, Rrp41p, Rrp42p, Rrp43p, Rrp45p, Rrp46p, Rrp6p, Ski2p, Ski3p, Ski7p, Ski8p, The, The Ski, The TRAMP, TRAMP
related to Inter-relation between components · 18
TRAMP complex → Air1p, All, But, For, If Trf4p, In, It, Mtr4p, Poly, RNA, Ski2, The, TRAMP, TRAMP4, TRAMP5, Trf4p/Air2p, Trf4p/Trf5p, Trf5p
related to Non-Canonical Poly(A) Polymerases · 15
TRAMP complex → Air1/Air2, Cid1, DNA, DNA Topoisomerases Top1p, In, Pol, Poly, Polymerases, RNA, RRM, The, The Trf4p, TRAMP, Trf4p, Trf5p
related to RNA substrates · 14
TRAMP complex → But, Different, Exosome, II, III, Long, Nab3, Pol, Pol II, RNA, RNAs, RrP6, The TRAMP, TRAMP
related to In humans · 11
TRAMP complex → MTR4, Q5XG87, Q8N3Z6, Q8NDF8, RNA, TENT4A, TENT4B, The TRAMP, TRAMP-like, ZCCHC7, Zinc
related to Conservation of TRAMP-mediated processes · 8
TRAMP complex → Air1p, Cid14p, Components, Mtr4p, Saccharomyces, Schizosaccharomyces, The TRAMP, TRAMP
related to Role in maintaining chromatin · 8
TRAMP complex → DNA, Hmt1p, Post-transcriptional, Rmt1p, RNA, The, TRAMP, Various TRAMP

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Important terminology

complex tramp rna mtr4p various exosome rnas polymerases poly trf4p activity degradation also components zinc knuckle proteins like maintaining trf5p

Entity relationships Subject–Predicate–Object triples

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SubjectPredicateObjectConfidenceSrc
TRAMP complexrelated to Conservation of TRAMP-mediated processesComponents0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesTRAMP0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesSaccharomyces0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesThe TRAMP0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesSchizosaccharomyces0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesCid14p0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesAir1p0.60section
TRAMP complexrelated to Conservation of TRAMP-mediated processesMtr4p0.60section
TRAMP complexrelated to In humansThe TRAMP0.60section
TRAMP complexrelated to In humansTRAMP-like0.60section
TRAMP complexrelated to In humansMTR40.60section
TRAMP complexrelated to In humansTENT4A0.60section

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