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Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.
The analysis highlights Art and Products as prominent areas in the source structure around DIS3.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around DIS3 shows recurring relationship patterns in the source. For example, DIS3 → 3'-5'-exoribonuclease activity, CUT catabolic process, cytoplasm, cytoplasmic exosome (RNase complex), cytosol, endonuclease activity, exonuclease activity, exonucleolytic catabolism of deadenylated mRNA, exosome (RNase complex), guanyl-nucleotide exchange factor activity, hydrolase activity, membrane, nuclear exosome (RNase complex), nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, protein binding, regulation of molecular function Another extracted example is DIS3 → abdominal wall, Achilles tendon, endothelial cell of lymphatic vessel, epiblast, ganglionic eminence, genital tubercle, islet of Langerhans, Paneth cell, popliteal artery, primitive streak, rectum, seminiferous tubule, somite, sperm, spermatid, stromal cell of endometrium, tail of embryo, testicle, tibial arteries, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp chr human band exosome gene rrp44 chromosome 13 complex enzyme location rnase nucleus mouse exonuclease protein 782 096 end
TTTA extracted 89 structured relationships around DIS3. Examples in this analysis include DIS3 → Aliases → DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease and DIS3 → Band → 13q21.33. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| DIS3 | Aliases | DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease | 1.00 | infobox |
| DIS3 | Band | 13q21.33 | 1.00 | infobox |
| DIS3 | Band | 14|14 E2.2 | 1.00 | infobox |
| DIS3 | Bgee | sperm | 1.00 | infobox |
| DIS3 | Bgee | Achilles tendon | 1.00 | infobox |
| DIS3 | Bgee | ventricular zone | 1.00 | infobox |
| DIS3 | Bgee | testicle | 1.00 | infobox |
| DIS3 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| DIS3 | Bgee | ganglionic eminence | 1.00 | infobox |
| DIS3 | Bgee | rectum | 1.00 | infobox |
| DIS3 | Bgee | islet of Langerhans | 1.00 | infobox |
| DIS3 | Bgee | popliteal artery | 1.00 | infobox |
| DIS3 | Bgee | tibial arteries | 1.00 | infobox |
| DIS3 | Bgee | primitive streak | 1.00 | infobox |
| DIS3 | Bgee | spermatid | 1.00 | infobox |
| DIS3 | Bgee | epiblast | 1.00 | infobox |
| DIS3 | Bgee | tail of embryo | 1.00 | infobox |
| DIS3 | Bgee | seminiferous tubule | 1.00 | infobox |
| DIS3 | Bgee | somite | 1.00 | infobox |
| DIS3 | Bgee | abdominal wall | 1.00 | infobox |
| DIS3 | Bgee | genital tubercle | 1.00 | infobox |
| DIS3 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| DIS3 | Bgee | Paneth cell | 1.00 | infobox |
| DIS3 | BioGPS | More reference expression data | 1.00 | infobox |
| DIS3 | Chr. | Chromosome 13 (human) | 1.00 | infobox |
| DIS3 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| DIS3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| DIS3 | End | 72,782,096 bp | 1.00 | infobox |
| DIS3 | End | 99,337,206 bp | 1.00 | infobox |
| DIS3 | Ensembl | ENSG00000083520 | 1.00 | infobox |
The concept neighborhoods around DIS3 bring nearby vocabulary together. In this analysis, examples include Exosome, Gene and Exonuclease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the DIS3 map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around DIS3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — DIS3 · EN edition · Analysis: TopicsToTalkAbout
