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DIS3

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.

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Aliases
DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Band
13q21.33 · 14|14 E2.2
Bgee
sperm · Achilles tendon · ventricular zone · testicle · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 14 (mouse)
Databases
NCBI: entry; OMA: entry

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DIS3

Nodes7
Edges6
Triples89
Avg. degree1.71
Density0.285714
Components1

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DIS3

Top relations

Gene ontology · 28
DIS3 → 3'-5'-exoribonuclease activity, CUT catabolic process, cytoplasm, cytoplasmic exosome (RNase complex), cytosol, endonuclease activity, exonuclease activity, exonucleolytic catabolism of deadenylated mRNA, exosome (RNase complex), guanyl-nucleotide exchange factor activity, hydrolase activity, membrane, nuclear exosome (RNase complex), nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, protein binding, regulation of molecular function
Bgee · 20
DIS3 → abdominal wall, Achilles tendon, endothelial cell of lymphatic vessel, epiblast, ganglionic eminence, genital tubercle, islet of Langerhans, Paneth cell, popliteal artery, primitive streak, rectum, seminiferous tubule, somite, sperm, spermatid, stromal cell of endometrium, tail of embryo, testicle, tibial arteries, ventricular zone
RNA expression pattern · 20
DIS3 → abdominal wall, Achilles tendon, endothelial cell of lymphatic vessel, epiblast, ganglionic eminence, genital tubercle, islet of Langerhans, Paneth cell, popliteal artery, primitive streak, rectum, seminiferous tubule, somite, sperm, spermatid, stromal cell of endometrium, tail of embryo, testicle, tibial arteries, ventricular zone
Band · 2
DIS3 → 13q21.33, 14|14 E2.2
Chr. · 2
DIS3 → Chromosome 13 (human), Chromosome 14 (mouse)
End · 2
DIS3 → 72,782,096 bp, 99,337,206 bp
Aliases · 1
DIS3 → DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
BioGPS · 1
DIS3 → More reference expression data
Databases · 1
DIS3 → NCBI: entry; OMA: entry
Ensembl · 1
DIS3 → ENSG00000083520

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Important terminology

bp chr human band exosome gene rrp44 chromosome 13 complex enzyme location rnase nucleus mouse exonuclease protein 782 096 end

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DIS3AliasesDIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease1.00infobox
DIS3Band13q21.331.00infobox
DIS3Band14|14 E2.21.00infobox
DIS3Bgeesperm1.00infobox
DIS3BgeeAchilles tendon1.00infobox
DIS3Bgeeventricular zone1.00infobox
DIS3Bgeetesticle1.00infobox
DIS3Bgeestromal cell of endometrium1.00infobox
DIS3Bgeeganglionic eminence1.00infobox
DIS3Bgeerectum1.00infobox
DIS3Bgeeislet of Langerhans1.00infobox
DIS3Bgeepopliteal artery1.00infobox
DIS3Bgeetibial arteries1.00infobox
DIS3Bgeeprimitive streak1.00infobox
DIS3Bgeespermatid1.00infobox
DIS3Bgeeepiblast1.00infobox
DIS3Bgeetail of embryo1.00infobox
DIS3Bgeeseminiferous tubule1.00infobox
DIS3Bgeesomite1.00infobox
DIS3Bgeeabdominal wall1.00infobox
DIS3Bgeegenital tubercle1.00infobox
DIS3Bgeeendothelial cell of lymphatic vessel1.00infobox
DIS3BgeePaneth cell1.00infobox
DIS3BioGPSMore reference expression data1.00infobox
DIS3Chr.Chromosome 13 (human)1.00infobox
DIS3Chr.Chromosome 14 (mouse)1.00infobox
DIS3DatabasesNCBI: entry; OMA: entry1.00infobox
DIS3End72,782,096 bp1.00infobox
DIS3End99,337,206 bp1.00infobox
DIS3EnsemblENSG000000835201.00infobox

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