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Lipopolysaccharide

Lipopolysaccharide (LPS), now more commonly known as endotoxin, is a collective term for components of the outermost membrane of the cell envelope of Gram-negative bacteria, such as E. coli and Salmonella with a common structural architecture. Lipopolysaccharides are large molecules consisting of three parts: an outer core polysaccharide termed the…

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Biological effects on hosts infected with Gram-negative bacteria

CD14TLR4MD2ReceptorMonocytes
60 related topics

Health effects

Host-pathogen interfaceSmall bowel bacterial overgrowth syndromeEndothelialCapillary leak syndromeDisseminated intravascular coagulation
32 related topics

Composition

AmphipathicCore oligosaccharideGlycanPolymerHydrophobic
15 related topics

Role as contaminant in biotechnology and research

PlasmidDNAIndustrial fermentationOvalbuminDepyrogenation
10 related topics

Topics to explore

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Overview

Discovery

Functions in bacteria

Composition

Lipooligosaccharide

LPS detoxification

Biosynthesis and transport

Biological effects on hosts infected with Gram-negative bacteria

Health effects

Role as contaminant in biotechnology and research

Advanced semantic analysis

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Map overview Semantic statistics

Lipopolysaccharide

Nodes172
Edges171
Triples38
Avg. degree1.99
Density0.011628
Components1

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Lipopolysaccharide

Top relations

related to Testing · 8
Lipopolysaccharide → Additionally, Gram-negative, LPS, Since LPS, Swiftly, The, Therefore, This
related to Role as contaminant in biotechnology and research · 6
Lipopolysaccharide → AHR, Commercially, DNA, Lipopolysaccharides, LPS, Ovalbumin
related to External links · 4
Lipopolysaccharide → Lipopolysaccharides, Medicine Medical Subject Headings, MeSH, National Library

Important terminology Word statistics

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Important terminology

lps bacteria lipid also bacterial cell immune may endotoxin membrane gram-negative los outer blood host role oligosaccharide cells human core

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
amoebaeinstance ofand interactions with predators0.80text
heptoseinstance ofis a target for recognition by host antibodies.CoreThe core domain always contains an oligosaccharide component that attaches directly to lipid A and commonly contains sugars0.80text
3-Deoxy-D-manno-oct-2-ulosonic acidinstance ofis a target for recognition by host antibodies.CoreThe core domain always contains an oligosaccharide component that attaches directly to lipid A and commonly contains sugars0.80text
heptoseinstance ofCoreThe core domain always contains an oligosaccharide component that attaches directly to lipid A and commonly contains sugars0.80text
3-Deoxy-D-manno-oct-2-ulosonic acidinstance ofCoreThe core domain always contains an oligosaccharide component that attaches directly to lipid A and commonly contains sugars0.80text
endotoxemiainstance ofit can lead to disease0.80text
endotoxic septic shock.Immune responseLPS acts as the prototypical endotoxin because it binds the CD14/TLR4/MD2 receptor complex in many cell typesinstance ofit can lead to disease0.80text
but especially in monocytesinstance ofit can lead to disease0.80text
dendritic cellsinstance ofit can lead to disease0.80text
macrophagesinstance ofit can lead to disease0.80text
B cellsinstance ofit can lead to disease0.80text
which promotes the secretion of pro-inflammatory cytokinesinstance ofit can lead to disease0.80text

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