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TTRAP

Transforming growth factor-β (TGF-β) principally relays its effects through the Smad pathway however, accumulating evidence indicate that alternative signalling routes are also employed by this pleiotropic cytokine. For instance recently, we have demonstrated that ligand-occupied TGF-β receptors can directly trigger the TRAF6-TAK1 signalling module…

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Aliases
TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P
Band
6p22.3 · 13 A3.1|13 10.7 cM
Bgee
jejunal mucosa · mucosa of sigmoid colon · mucosa of ileum · rectum · duodenum
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 13 (mouse)

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Overview

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Map overview Semantic statistics

TTRAP

Nodes13
Edges12
Triples90
Avg. degree1.85
Density0.153846
Components1

How this topic connects Entity context

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TTRAP

Top relations

Gene ontology · 24
TTRAP → 5'-tyrosyl-DNA phosphodiesterase activity, aggresome, cell surface receptor signaling pathway, cellular response to DNA damage stimulus, cytoplasm, DNA repair, double-strand break repair, hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, negative regulation of nucleic acid-templated transcription, neuron development, nuclear body, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, PML body
Bgee · 20
TTRAP → abdominal wall, atrioventricular valve, ciliary body, duodenum, epiblast, gonad, islet of Langerhans, jejunal mucosa, kidney tubule, maxillary prominence, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, palpebral conjunctiva, primitive streak, rectum, saccule, tail of embryo
RNA expression pattern · 20
TTRAP → abdominal wall, atrioventricular valve, ciliary body, duodenum, epiblast, gonad, islet of Langerhans, jejunal mucosa, kidney tubule, maxillary prominence, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, palpebral conjunctiva, primitive streak, rectum, saccule, tail of embryo
related to Interactions · 3
TTRAP → CD40, ETS1, TNFRSF1B
Band · 2
TTRAP → 13 A3.1|13 10.7 cM, 6p22.3
Chr. · 2
TTRAP → Chromosome 13 (mouse), Chromosome 6 (human)
End · 2
TTRAP → 24,666,930 bp, 25,026,136 bp
Aliases · 1
TTRAP → TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2
Available structures · 1
TTRAP → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P
BioGPS · 1
TTRAP → More reference expression data

Important terminology Word statistics

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Important terminology

tgf-β bp protein chr human band chromosome gene pathway component location activation signalling receptors traf6-tak1 module resulting tdp2 mouse signaling

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TTRAPAliasesTDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 21.00infobox
TTRAPAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P1.00infobox
TTRAPBand6p22.31.00infobox
TTRAPBand13 A3.1|13 10.7 cM1.00infobox
TTRAPBgeejejunal mucosa1.00infobox
TTRAPBgeemucosa of sigmoid colon1.00infobox
TTRAPBgeemucosa of ileum1.00infobox
TTRAPBgeerectum1.00infobox
TTRAPBgeeduodenum1.00infobox
TTRAPBgeemucosa of transverse colon1.00infobox
TTRAPBgeegonad1.00infobox
TTRAPBgeepalpebral conjunctiva1.00infobox
TTRAPBgeekidney tubule1.00infobox
TTRAPBgeeislet of Langerhans1.00infobox
TTRAPBgeeotic placode1.00infobox
TTRAPBgeesaccule1.00infobox
TTRAPBgeeotic vesicle1.00infobox
TTRAPBgeeprimitive streak1.00infobox
TTRAPBgeetail of embryo1.00infobox
TTRAPBgeeabdominal wall1.00infobox
TTRAPBgeeatrioventricular valve1.00infobox
TTRAPBgeeepiblast1.00infobox
TTRAPBgeeciliary body1.00infobox
TTRAPBgeemaxillary prominence1.00infobox
TTRAPBioGPSMore reference expression data1.00infobox
TTRAPChr.Chromosome 6 (human)1.00infobox
TTRAPChr.Chromosome 13 (mouse)1.00infobox
TTRAPDatabasesNCBI: entry; OMA: entry1.00infobox
TTRAPEnd24,666,930 bp1.00infobox
TTRAPEnd25,026,136 bp1.00infobox

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