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Transforming growth factor-β (TGF-β) principally relays its effects through the Smad pathway however, accumulating evidence indicate that alternative signalling routes are also employed by this pleiotropic cytokine. For instance recently, we have demonstrated that ligand-occupied TGF-β receptors can directly trigger the TRAF6-TAK1 signalling module…
The analysis highlights Interactions and Overview as prominent areas in the source structure around TTRAP.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around TTRAP shows recurring relationship patterns in the source. For example, TTRAP → 5'-tyrosyl-DNA phosphodiesterase activity, aggresome, cell surface receptor signaling pathway, cellular response to DNA damage stimulus, cytoplasm, DNA repair, double-strand break repair, hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, negative regulation of nucleic acid-templated transcription, neuron development, nuclear body, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, PML body Another extracted example is TTRAP → abdominal wall, atrioventricular valve, ciliary body, duodenum, epiblast, gonad, islet of Langerhans, jejunal mucosa, kidney tubule, maxillary prominence, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, palpebral conjunctiva, primitive streak, rectum, saccule, tail of embryo. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
tgf-β bp protein chr human band chromosome gene pathway component location activation signalling receptors traf6-tak1 module resulting tdp2 mouse signaling
TTTA extracted 90 structured relationships around TTRAP. Examples in this analysis include TTRAP → Aliases → TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2 and TTRAP → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TTRAP | Aliases | TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2 | 1.00 | infobox |
| TTRAP | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P | 1.00 | infobox |
| TTRAP | Band | 6p22.3 | 1.00 | infobox |
| TTRAP | Band | 13 A3.1|13 10.7 cM | 1.00 | infobox |
| TTRAP | Bgee | jejunal mucosa | 1.00 | infobox |
| TTRAP | Bgee | mucosa of sigmoid colon | 1.00 | infobox |
| TTRAP | Bgee | mucosa of ileum | 1.00 | infobox |
| TTRAP | Bgee | rectum | 1.00 | infobox |
| TTRAP | Bgee | duodenum | 1.00 | infobox |
| TTRAP | Bgee | mucosa of transverse colon | 1.00 | infobox |
| TTRAP | Bgee | gonad | 1.00 | infobox |
| TTRAP | Bgee | palpebral conjunctiva | 1.00 | infobox |
| TTRAP | Bgee | kidney tubule | 1.00 | infobox |
| TTRAP | Bgee | islet of Langerhans | 1.00 | infobox |
| TTRAP | Bgee | otic placode | 1.00 | infobox |
| TTRAP | Bgee | saccule | 1.00 | infobox |
| TTRAP | Bgee | otic vesicle | 1.00 | infobox |
| TTRAP | Bgee | primitive streak | 1.00 | infobox |
| TTRAP | Bgee | tail of embryo | 1.00 | infobox |
| TTRAP | Bgee | abdominal wall | 1.00 | infobox |
| TTRAP | Bgee | atrioventricular valve | 1.00 | infobox |
| TTRAP | Bgee | epiblast | 1.00 | infobox |
| TTRAP | Bgee | ciliary body | 1.00 | infobox |
| TTRAP | Bgee | maxillary prominence | 1.00 | infobox |
| TTRAP | BioGPS | More reference expression data | 1.00 | infobox |
| TTRAP | Chr. | Chromosome 6 (human) | 1.00 | infobox |
| TTRAP | Chr. | Chromosome 13 (mouse) | 1.00 | infobox |
| TTRAP | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TTRAP | End | 24,666,930 bp | 1.00 | infobox |
| TTRAP | End | 25,026,136 bp | 1.00 | infobox |
The concept neighborhoods around TTRAP bring nearby vocabulary together. In this analysis, examples include Component, Cell and Cellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TTRAP, one of the stronger structural bridges in this analysis connects TTRAP with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TTRAP to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TTRAP · EN edition · Analysis: TopicsToTalkAbout