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TTRAP: Interactions & Overview

Transforming growth factor-β (TGF-β) principally relays its effects through the Smad pathway however, accumulating evidence indicate that alternative signalling routes are also employed by this pleiotropic cytokine. For instance recently, we have demonstrated that ligand-occupied TGF-β receptors can directly trigger the TRAF6-TAK1 signalling module…

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TTRAP topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around TTRAP.

Related topics
8
Source areas
2
Connected nodes
10
Extracted relationships
90
Related term clusters
4
Bridge connections
10

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 4 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P
Band
6p22.3 · 13 A3.1|13 10.7 cM
Bgee
jejunal mucosa · mucosa of sigmoid colon · mucosa of ileum · rectum · duodenum
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 13 (mouse)

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TTRAP
4Transforming growth factor-β · SMAD (protein) · Ligand
4Protein-protein interaction · ETS1 · TNFRSF1B

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How TTRAP connects Entity context

The extracted context around TTRAP shows recurring relationship patterns in the source. For example, TTRAP → 5'-tyrosyl-DNA phosphodiesterase activity, aggresome, cell surface receptor signaling pathway, cellular response to DNA damage stimulus, cytoplasm, DNA repair, double-strand break repair, hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, negative regulation of nucleic acid-templated transcription, neuron development, nuclear body, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, PML body Another extracted example is TTRAP → abdominal wall, atrioventricular valve, ciliary body, duodenum, epiblast, gonad, islet of Langerhans, jejunal mucosa, kidney tubule, maxillary prominence, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, palpebral conjunctiva, primitive streak, rectum, saccule, tail of embryo. Use these groups to spot repeated connection types before inspecting the individual relationships.

TTRAP

Top relations

Gene ontology · 24
TTRAP → 5'-tyrosyl-DNA phosphodiesterase activity, aggresome, cell surface receptor signaling pathway, cellular response to DNA damage stimulus, cytoplasm, DNA repair, double-strand break repair, hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, negative regulation of nucleic acid-templated transcription, neuron development, nuclear body, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, PML body
Bgee · 20
TTRAP → abdominal wall, atrioventricular valve, ciliary body, duodenum, epiblast, gonad, islet of Langerhans, jejunal mucosa, kidney tubule, maxillary prominence, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, palpebral conjunctiva, primitive streak, rectum, saccule, tail of embryo
RNA expression pattern · 20
TTRAP → abdominal wall, atrioventricular valve, ciliary body, duodenum, epiblast, gonad, islet of Langerhans, jejunal mucosa, kidney tubule, maxillary prominence, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, palpebral conjunctiva, primitive streak, rectum, saccule, tail of embryo
related to Interactions · 3
TTRAP → CD40, ETS1, TNFRSF1B
Band · 2
TTRAP → 13 A3.1|13 10.7 cM, 6p22.3
Chr. · 2
TTRAP → Chromosome 13 (mouse), Chromosome 6 (human)
End · 2
TTRAP → 24,666,930 bp, 25,026,136 bp
Aliases · 1
TTRAP → TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2
Available structures · 1
TTRAP → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P
BioGPS · 1
TTRAP → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tgf-β bp protein chr human band chromosome gene pathway component location activation signalling receptors traf6-tak1 module resulting tdp2 mouse signaling

TTRAP relationships Subject–Predicate–Object triples

TTTA extracted 90 structured relationships around TTRAP. Examples in this analysis include TTRAP → Aliases → TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2 and TTRAP → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TTRAPAliasesTDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 21.00infobox
TTRAPAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J3S, 5INO, 5J3P1.00infobox
TTRAPBand6p22.31.00infobox
TTRAPBand13 A3.1|13 10.7 cM1.00infobox
TTRAPBgeejejunal mucosa1.00infobox
TTRAPBgeemucosa of sigmoid colon1.00infobox
TTRAPBgeemucosa of ileum1.00infobox
TTRAPBgeerectum1.00infobox
TTRAPBgeeduodenum1.00infobox
TTRAPBgeemucosa of transverse colon1.00infobox
TTRAPBgeegonad1.00infobox
TTRAPBgeepalpebral conjunctiva1.00infobox
TTRAPBgeekidney tubule1.00infobox
TTRAPBgeeislet of Langerhans1.00infobox
TTRAPBgeeotic placode1.00infobox
TTRAPBgeesaccule1.00infobox
TTRAPBgeeotic vesicle1.00infobox
TTRAPBgeeprimitive streak1.00infobox
TTRAPBgeetail of embryo1.00infobox
TTRAPBgeeabdominal wall1.00infobox
TTRAPBgeeatrioventricular valve1.00infobox
TTRAPBgeeepiblast1.00infobox
TTRAPBgeeciliary body1.00infobox
TTRAPBgeemaxillary prominence1.00infobox
TTRAPBioGPSMore reference expression data1.00infobox
TTRAPChr.Chromosome 6 (human)1.00infobox
TTRAPChr.Chromosome 13 (mouse)1.00infobox
TTRAPDatabasesNCBI: entry; OMA: entry1.00infobox
TTRAPEnd24,666,930 bp1.00infobox
TTRAPEnd25,026,136 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around TTRAP bring nearby vocabulary together. In this analysis, examples include Component, Cell and Cellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TTRAP
    • Component
    • Cell
    • Cellular
    • Function
    • Phosphodiesterase
    • Process
    • Search
    • Tdp2
    • Location
    • Pathway
    • Chromosome
    • Gene
  • ttrap
    • Component
    • Cell
    • Cellular
    • Function
    • Phosphodiesterase
    • Process
    • Search
    • Tdp2
    • Location
    • Pathway
    • Chromosome
    • Gene
  • cd40
    • Protein
    • Cell
    • Cellular
    • Dna
    • End
    • Function
    • Mouse
    • Phosphodiesterase
    • Process
    • Regulation
    • Search
    • Signaling
  • signalling routes
    • Tgf-β
    • Module
    • Receptors
    • Resulting
    • Traf6-tak1
    • Activation

Connections between topic areas Semantic bridges

For TTRAP, one of the stronger structural bridges in this analysis connects TTRAP with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TTRAP — Overview · splits 6 ⟂ 5
TTRAP — Interactions · splits 6 ⟂ 5

Map overview Semantic statistics

TTRAP

Nodes11
Edges10
Triples90
Avg. degree1.82
Density0.181818
Components1

Source & methodology

TTTA analyzes the structure around TTRAP to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TTRAP · EN edition · Analysis: TopicsToTalkAbout

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