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Immunoglobulin class switching

Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. During this process, the constant-region portion of the antibody heavy chain is…

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Mechanism

B cell receptorV(D)J recombinationIgMIgDLocus
23 related topics

Gene regulatory sequences responsible for class switching

Locus suicide recombination
1 related topics

Overview

B cellImmunoglobulinIsotypeIgMIgG
9 related topics

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Mechanism

Gene regulatory sequences responsible for class switching

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Immunoglobulin class switching

Nodes37
Edges36
Triples0
Avg. degree1.95
Density0.054054
Components1

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Important terminology

class antibody chain switching heavy region recombination csr process igd immunoglobulin cell dna constant variable different exons igm switch mechanism

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