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Amylin

Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing spikes in blood glucose levels after a meal.

History, Synthesis & Clinical significance

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Aliases
IAPP, DAP, IAP, islet amyloid polypeptide
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1
Band
12p12.1 · 6 G2|6 73.81 cM
Bgee
islet of Langerhans · beta cell · body of pancreas · right lobe of liver · left testis
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

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Overview

Synthesis

Regulation

Function

Structure

History

Clinical significance

Pharmacology

Receptors

Advanced semantic analysis

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Map overview Semantic statistics

Amylin

Nodes72
Edges71
Triples164
Avg. degree1.97
Density0.027778
Components1

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Amylin

Top relations

Gene ontology · 32
Amylin → adenylate cyclase-activating G protein-coupled receptor signaling pathway, amylin receptor signaling pathway, amyloid fibril formation, amyloid-beta binding, apoptotic process, cell-cell signaling, eating behavior, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, hormone activity, identical protein binding, inclusion body, negative regulation of amyloid fibril formation, negative regulation of bone resorption, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of mitochondrion organization, negative regulation of protein homooligomerization, positive regulation of apoptotic process
Bgee · 19
Amylin → beta cell, body of pancreas, bone marrow, crypt of lieberkuhn of small intestine, duodenum, embryo, female breast, human fetus, islet of Langerhans, jejunum, lactiferous gland, left testis, migratory enteric neural crest cell, Paneth cell, pyloric antrum, right lobe of liver, right testis, Rostral migratory stream, supraoptic nucleus
RNA expression pattern · 19
Amylin → beta cell, body of pancreas, bone marrow, crypt of lieberkuhn of small intestine, duodenum, embryo, female breast, human fetus, islet of Langerhans, jejunum, lactiferous gland, left testis, migratory enteric neural crest cell, Paneth cell, pyloric antrum, right lobe of liver, right testis, Rostral migratory stream, supraoptic nucleus
related to Synthesis · 19
Amylin → After, At, C-terminus, C-terminus Carboxypeptidase, IAPP, KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2, KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYG, KR, Later, MGILKLQVFLIVLSVALNHLKA, N-terminus, NAVEVLKREPLNYLPL, Once, PAM, PC1/3, PC2, ProIAPP, The, TPIESHQVEKR
related to External links · 14
Amylin → Amylin Nucleation Site, April, Archived, DAP, Human DAP, Human IAPP, IAPP, Medicine Medical Subject Headings, MeSH, National Library, PDB Entry, RCSB Protein Data Bank, Retrieved, UCSC Genome Browser
related to Structure · 12
Amylin → Both, C-terminus, IAPP, It, KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY, Later, NMR, Rat IAPP, Rats, Studies, The, Within
related to Pharmacology · 9
Amylin → Another, Cagrilintide, CagriSema, II DM, Insulin, Novo Nordisk, Phase, Semaglutide, Symlin
related to Function · 7
Amylin → Amylin's, Appearance, It, Ra, The, These, They
related to history · 5
Amylin → Before, IAP, In, Insulinoma Amyloid Peptide, This
related to Receptors · 5
Amylin → All, RAMP1, RAMP2, RAMP3, There

Important terminology Word statistics

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Important terminology

amyloid iapp diabetes insulin proiapp human type β-cells pancreatic islet peptide bp glucose formation protein gene chr band regulation effect

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
AmylinAliasesIAPP, DAP, IAP, islet amyloid polypeptide1.00infobox
AmylinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG11.00infobox
AmylinBand12p12.11.00infobox
AmylinBand6 G2|6 73.81 cM1.00infobox
AmylinBgeeislet of Langerhans1.00infobox
AmylinBgeebeta cell1.00infobox
AmylinBgeebody of pancreas1.00infobox
AmylinBgeeright lobe of liver1.00infobox
AmylinBgeeleft testis1.00infobox
AmylinBgeeright testis1.00infobox
AmylinBgeeduodenum1.00infobox
AmylinBgeebone marrow1.00infobox
AmylinBgeefemale breast1.00infobox
AmylinBgeelactiferous gland1.00infobox
AmylinBgeepyloric antrum1.00infobox
AmylinBgeeembryo1.00infobox
AmylinBgeemigratory enteric neural crest cell1.00infobox
AmylinBgeehuman fetus1.00infobox
AmylinBgeePaneth cell1.00infobox
AmylinBgeesupraoptic nucleus1.00infobox
AmylinBgeejejunum1.00infobox
AmylinBgeeRostral migratory stream1.00infobox
AmylinBgeecrypt of lieberkuhn of small intestine1.00infobox
AmylinBioGPSMore reference expression data1.00infobox
AmylinChr.Chromosome 12 (human)1.00infobox
AmylinChr.Chromosome 6 (mouse)1.00infobox
AmylinDatabasesNCBI: entry; OMA: entry1.00infobox
AmylinEnd21,379,980 bp1.00infobox
AmylinEnd142,249,687 bp1.00infobox
AmylinEnsemblENSG000001213511.00infobox

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