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Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing spikes in blood glucose levels after a meal.
History, Synthesis & Clinical significance
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amyloid iapp diabetes insulin proiapp human type β-cells pancreatic islet peptide bp glucose formation protein gene chr band regulation effect
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Amylin | Aliases | IAPP, DAP, IAP, islet amyloid polypeptide | 1.00 | infobox |
| Amylin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1 | 1.00 | infobox |
| Amylin | Band | 12p12.1 | 1.00 | infobox |
| Amylin | Band | 6 G2|6 73.81 cM | 1.00 | infobox |
| Amylin | Bgee | islet of Langerhans | 1.00 | infobox |
| Amylin | Bgee | beta cell | 1.00 | infobox |
| Amylin | Bgee | body of pancreas | 1.00 | infobox |
| Amylin | Bgee | right lobe of liver | 1.00 | infobox |
| Amylin | Bgee | left testis | 1.00 | infobox |
| Amylin | Bgee | right testis | 1.00 | infobox |
| Amylin | Bgee | duodenum | 1.00 | infobox |
| Amylin | Bgee | bone marrow | 1.00 | infobox |
| Amylin | Bgee | female breast | 1.00 | infobox |
| Amylin | Bgee | lactiferous gland | 1.00 | infobox |
| Amylin | Bgee | pyloric antrum | 1.00 | infobox |
| Amylin | Bgee | embryo | 1.00 | infobox |
| Amylin | Bgee | migratory enteric neural crest cell | 1.00 | infobox |
| Amylin | Bgee | human fetus | 1.00 | infobox |
| Amylin | Bgee | Paneth cell | 1.00 | infobox |
| Amylin | Bgee | supraoptic nucleus | 1.00 | infobox |
| Amylin | Bgee | jejunum | 1.00 | infobox |
| Amylin | Bgee | Rostral migratory stream | 1.00 | infobox |
| Amylin | Bgee | crypt of lieberkuhn of small intestine | 1.00 | infobox |
| Amylin | BioGPS | More reference expression data | 1.00 | infobox |
| Amylin | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| Amylin | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| Amylin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Amylin | End | 21,379,980 bp | 1.00 | infobox |
| Amylin | End | 142,249,687 bp | 1.00 | infobox |
| Amylin | Ensembl | ENSG00000121351 | 1.00 | infobox |
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