Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing spikes in blood glucose levels after a meal.
The analysis highlights History, Synthesis and Clinical significance as prominent areas in the source structure around Amylin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Amylin shows recurring relationship patterns in the source. For example, Amylin → adenylate cyclase-activating G protein-coupled receptor signaling pathway, amylin receptor signaling pathway, amyloid fibril formation, amyloid-beta binding, apoptotic process, cell-cell signaling, eating behavior, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, hormone activity, identical protein binding, inclusion body, negative regulation of amyloid fibril formation, negative regulation of bone resorption, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of mitochondrion organization, negative regulation of protein homooligomerization, positive regulation of apoptotic process Another extracted example is Amylin → beta cell, body of pancreas, bone marrow, crypt of lieberkuhn of small intestine, duodenum, embryo, female breast, human fetus, islet of Langerhans, jejunum, lactiferous gland, left testis, migratory enteric neural crest cell, Paneth cell, pyloric antrum, right lobe of liver, right testis, Rostral migratory stream, supraoptic nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
amyloid iapp diabetes insulin proiapp human type β-cells pancreatic islet peptide bp glucose formation protein gene chr band regulation effect
TTTA extracted 164 structured relationships around Amylin. Examples in this analysis include Amylin → Aliases → IAPP, DAP, IAP, islet amyloid polypeptide and Amylin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Amylin | Aliases | IAPP, DAP, IAP, islet amyloid polypeptide | 1.00 | infobox |
| Amylin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1 | 1.00 | infobox |
| Amylin | Band | 12p12.1 | 1.00 | infobox |
| Amylin | Band | 6 G2|6 73.81 cM | 1.00 | infobox |
| Amylin | Bgee | islet of Langerhans | 1.00 | infobox |
| Amylin | Bgee | beta cell | 1.00 | infobox |
| Amylin | Bgee | body of pancreas | 1.00 | infobox |
| Amylin | Bgee | right lobe of liver | 1.00 | infobox |
| Amylin | Bgee | left testis | 1.00 | infobox |
| Amylin | Bgee | right testis | 1.00 | infobox |
| Amylin | Bgee | duodenum | 1.00 | infobox |
| Amylin | Bgee | bone marrow | 1.00 | infobox |
| Amylin | Bgee | female breast | 1.00 | infobox |
| Amylin | Bgee | lactiferous gland | 1.00 | infobox |
| Amylin | Bgee | pyloric antrum | 1.00 | infobox |
| Amylin | Bgee | embryo | 1.00 | infobox |
| Amylin | Bgee | migratory enteric neural crest cell | 1.00 | infobox |
| Amylin | Bgee | human fetus | 1.00 | infobox |
| Amylin | Bgee | Paneth cell | 1.00 | infobox |
| Amylin | Bgee | supraoptic nucleus | 1.00 | infobox |
| Amylin | Bgee | jejunum | 1.00 | infobox |
| Amylin | Bgee | Rostral migratory stream | 1.00 | infobox |
| Amylin | Bgee | crypt of lieberkuhn of small intestine | 1.00 | infobox |
| Amylin | BioGPS | More reference expression data | 1.00 | infobox |
| Amylin | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| Amylin | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| Amylin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Amylin | End | 21,379,980 bp | 1.00 | infobox |
| Amylin | End | 142,249,687 bp | 1.00 | infobox |
| Amylin | Ensembl | ENSG00000121351 | 1.00 | infobox |
The concept neighborhoods around Amylin bring nearby vocabulary together. In this analysis, examples include Type, Diabetes and Peptide. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Amylin, one of the stronger structural bridges in this analysis connects Amylin with Synthesis. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Amylin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Synthesis & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Amylin · EN edition · Analysis: TopicsToTalkAbout