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CDC20

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20…

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Aliases
CDC20, CDC20A, bA276H19.3, p55CDC, cell division cycle 20
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GGA, 4GGC, 4GGD, 4N14, 5G04
Band
1p34.2 · 4|4 D2.1
Bgee
oocyte · ventricular zone · secondary oocyte · embryo · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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Discovery

Structure

Interactions

Spindle assembly checkpoint

Cancer

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CDC20

Nodes44
Edges43
Triples172
Avg. degree1.95
Density0.045455
Components1

How this topic connects Entity context

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CDC20

Top relations

Gene ontology · 36
CDC20 → anaphase-promoting complex, anaphase-promoting complex binding, anaphase-promoting complex-dependent catabolic process, cell cycle, cell differentiation, cell division, centrosome, cytoplasm, cytoskeleton, cytosol, enzyme binding, histone deacetylase binding, microtubule organizing center, mitotic sister chromatid cohesion, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, nervous system development, nucleoplasm, nucleus, perinuclear region of cytoplasm
Bgee · 20
CDC20 → abdominal wall, embryo, endocardial cushion, epiblast, external carotid artery, ganglionic eminence, gonad, hair follicle, internal carotid artery, left testis, medial ganglionic eminence, mucosa of transverse colon, oocyte, primitive streak, renal corpuscle, right testis, secondary oocyte, trabecular bone, ureter, ventricular zone
RNA expression pattern · 20
CDC20 → abdominal wall, embryo, endocardial cushion, epiblast, external carotid artery, ganglionic eminence, gonad, hair follicle, internal carotid artery, left testis, medial ganglionic eminence, mucosa of transverse colon, oocyte, primitive streak, renal corpuscle, right testis, secondary oocyte, trabecular bone, ureter, ventricular zone
related to Cdh1 · 17
CDC20 → After, APC/C, APC/CCdc20, CDC20-homologue, Cdh1, During, G1, G1/S, G1/S Cdks, How, S-phase, S/M, S/M Cdks, S/M-Cdks, The APC/CCdc20, Their, This
related to Regulation · 15
CDC20 → APC/C, APC/CCdc20, Cdh1, Cdk, Cdk1, Cdks, G1, However, Importantly, In, Multiple, Once, S/M, The APC/CCdc20, Therefore
related to Spindle assembly checkpoint · 13
CDC20 → APC/CCdc20, Bub1, Bub3, BubR1, In, Mad2, Mad3, MCC, Moreover, SAC, The, The APC/CCdc20, This
related to Structure · 12
CDC20 → APC/CCdh1, C-box, C-terminus, Cry, In, KEN-box, Mad2-interacting, N-terminus, Near, The, The KEN-box, WD40
related to Interactions · 7
CDC20 → ANAPC7BUB1B, CDC16, CDC27, Cyclin A1, FBXO5, HDAC1, HDAC2
related to Discovery · 4
CDC20 → APC/C, Cdc, Hartwell, However
related to Cancer · 3
CDC20 → For, In, It

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Important terminology

apc cell protein cycle anaphase complex ccdc20 cdh1 cdks gene cyclins human bp mitosis proteins chromosome chr band checkpoint thus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CDC20AliasesCDC20, CDC20A, bA276H19.3, p55CDC, cell division cycle 201.00infobox
CDC20Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GGA, 4GGC, 4GGD, 4N14, 5G041.00infobox
CDC20Band1p34.21.00infobox
CDC20Band4|4 D2.11.00infobox
CDC20Bgeeoocyte1.00infobox
CDC20Bgeeventricular zone1.00infobox
CDC20Bgeesecondary oocyte1.00infobox
CDC20Bgeeembryo1.00infobox
CDC20Bgeeganglionic eminence1.00infobox
CDC20Bgeeleft testis1.00infobox
CDC20Bgeeright testis1.00infobox
CDC20Bgeemucosa of transverse colon1.00infobox
CDC20Bgeegonad1.00infobox
CDC20Bgeetrabecular bone1.00infobox
CDC20Bgeemedial ganglionic eminence1.00infobox
CDC20Bgeeprimitive streak1.00infobox
CDC20Bgeeabdominal wall1.00infobox
CDC20Bgeeureter1.00infobox
CDC20Bgeeendocardial cushion1.00infobox
CDC20Bgeeinternal carotid artery1.00infobox
CDC20Bgeeepiblast1.00infobox
CDC20Bgeerenal corpuscle1.00infobox
CDC20Bgeeexternal carotid artery1.00infobox
CDC20Bgeehair follicle1.00infobox
CDC20BioGPSMore reference expression data1.00infobox
CDC20Chr.Chromosome 1 (human)1.00infobox
CDC20Chr.Chromosome 4 (mouse)1.00infobox
CDC20DatabasesNCBI: entry; OMA: entry1.00infobox
CDC20End43,363,203 bp1.00infobox
CDC20End118,294,549 bp1.00infobox

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