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BUB3: Role in the spindle assembly checkpoint, Function & Interactions

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.

Language: English [EN]
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BUB3 topic overview

The analysis highlights Role in the spindle assembly checkpoint, Function and Interactions as prominent areas in the source structure around BUB3.

Related topics
28
Source areas
5
Connected nodes
33
Extracted relationships
138
Concept neighborhoods
18
Bridge connections
33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 8 topics
Role in the spindle assembly checkpoint · 7 topics
Function · 6 topics
Interactions · 4 topics
Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BUB3, BUB3L, hmitotic checkpoint protein, BUB3 mitotic checkpoint protein
Band
10q26.13 · 7 F3|7 74.36 cM
Bgee
gingival epithelium · sperm · epithelium of nasopharynx · germinal epithelium · Epithelium of choroid plexus
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Role in the spindle assembly checkpoint

Structure

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BUB3 connects Entity context

The extracted context around BUB3 shows recurring relationship patterns in the source. For example, BUB3 → anaphase-promoting complex-dependent catabolic process, attachment of spindle microtubules to kinetochore, bub1-bub3 complex, cell cycle, cell division, chromosome, chromosome segregation, chromosome, centromeric region, cytosol, kinetochore, meiosis, mitotic checkpoint complex, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, nucleoplasm, nucleus, protein binding, protein localization to kinetochore, regulation of chromosome segregation, regulation of mitotic cell cycle phase transition Another extracted example is BUB3 → abdominal wall, condyle, embryo, endocardial cushion, Epithelium of choroid plexus, epithelium of nasopharynx, ganglionic eminence, germinal epithelium, gingival epithelium, gonad, lymph node, mandibular prominence, maxillary prominence, medial ganglionic eminence, primitive streak, somite, sperm, stria vascularis, ventricular zone, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

BUB3

Top relations

Gene ontology · 22
BUB3 → anaphase-promoting complex-dependent catabolic process, attachment of spindle microtubules to kinetochore, bub1-bub3 complex, cell cycle, cell division, chromosome, chromosome segregation, chromosome, centromeric region, cytosol, kinetochore, meiosis, mitotic checkpoint complex, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, nucleoplasm, nucleus, protein binding, protein localization to kinetochore, regulation of chromosome segregation, regulation of mitotic cell cycle phase transition
Bgee · 20
BUB3 → abdominal wall, condyle, embryo, endocardial cushion, Epithelium of choroid plexus, epithelium of nasopharynx, ganglionic eminence, germinal epithelium, gingival epithelium, gonad, lymph node, mandibular prominence, maxillary prominence, medial ganglionic eminence, primitive streak, somite, sperm, stria vascularis, ventricular zone, vestibular sensory epithelium
RNA expression pattern · 20
BUB3 → abdominal wall, condyle, embryo, endocardial cushion, Epithelium of choroid plexus, epithelium of nasopharynx, ganglionic eminence, germinal epithelium, gingival epithelium, gonad, lymph node, mandibular prominence, maxillary prominence, medial ganglionic eminence, primitive streak, somite, sperm, stria vascularis, ventricular zone, vestibular sensory epithelium
related to Structure · 12
BUB3 → Both, Bub1, Gle2p-binding-sequence, GLEBS, Mad3, Mutation, Rae1, SAC, The, This, VAVE, WD40
related to Function · 11
BUB3 → After, BUB1, BUB2, For, If, Mad1, Mad2, Mad3, MPS1, The, This
related to Role in the spindle assembly checkpoint · 9
BUB3 → APC, APCCdc20, At, BubR1, Cdc20, Mad2-Cdc20, SAC, Securin, The
related to Interactions · 8
BUB3 → Additionally, BUB1B, Cdc20, HDAC1, Histone, Mad1-Bub1, Mad2, Mad3
related to Regulation · 7
BUB3 → After, Bub3-Cdc20, BubR1-Bub3, Mad2, Mad3, SAC, When
related to Clinical significance · 6
BUB3 → APC/C, BUB1, BUB1/BUB3, BUBR1, CDC20, MAD1L1
Band · 2
BUB3 → 10q26.13, 7 F3|7 74.36 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

checkpoint complex protein bub1 spindle mitotic anaphase chromosome assembly sac bp human kinetochore mad3 gene chr band mad2 interaction proteins

BUB3 relationships Subject–Predicate–Object triples

TTTA extracted 138 structured relationships around BUB3. Examples in this analysis include BUB3 → Aliases → BUB3, BUB3L, hmitotic checkpoint protein, BUB3 mitotic checkpoint protein and BUB3 → Band → 10q26.13. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BUB3AliasesBUB3, BUB3L, hmitotic checkpoint protein, BUB3 mitotic checkpoint protein1.00infobox
BUB3Band10q26.131.00infobox
BUB3Band7 F3|7 74.36 cM1.00infobox
BUB3Bgeegingival epithelium1.00infobox
BUB3Bgeesperm1.00infobox
BUB3Bgeeepithelium of nasopharynx1.00infobox
BUB3Bgeegerminal epithelium1.00infobox
BUB3BgeeEpithelium of choroid plexus1.00infobox
BUB3Bgeeventricular zone1.00infobox
BUB3Bgeelymph node1.00infobox
BUB3Bgeeembryo1.00infobox
BUB3Bgeeganglionic eminence1.00infobox
BUB3Bgeegonad1.00infobox
BUB3Bgeevestibular sensory epithelium1.00infobox
BUB3Bgeeprimitive streak1.00infobox
BUB3Bgeemaxillary prominence1.00infobox
BUB3Bgeemandibular prominence1.00infobox
BUB3Bgeeabdominal wall1.00infobox
BUB3Bgeestria vascularis1.00infobox
BUB3Bgeemedial ganglionic eminence1.00infobox
BUB3Bgeeendocardial cushion1.00infobox
BUB3Bgeecondyle1.00infobox
BUB3Bgeesomite1.00infobox
BUB3BioGPSMore reference expression data1.00infobox
BUB3Chr.Chromosome 10 (human)1.00infobox
BUB3Chr.Chromosome 7 (mouse)1.00infobox
BUB3DatabasesNCBI: entry; OMA: entry1.00infobox
BUB3End123,170,467 bp1.00infobox
BUB3End131,173,624 bp1.00infobox
BUB3EnsemblENSG000001544731.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BUB3 bring nearby vocabulary together. In this analysis, examples include Protein, Checkpoint and Bub1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BUB3
    • Protein
    • Checkpoint
    • Bub1
    • Complex
    • Assembly
    • Mad3
    • Sac
    • Spindle
    • Apc
    • Bubr1
    • Cdc20
    • Proteins
  • bub3
    • Protein
    • Checkpoint
    • Bub1
    • Complex
    • Assembly
    • Mad3
    • Sac
    • Spindle
    • Apc
    • Bubr1
    • Cdc20
    • Proteins
  • protein
    • Regulation
    • Spindle
    • Function
    • Wd40
    • Cell
    • Location
    • Proteins
    • Bp
    • Chr
    • Human
    • Mad2
    • Chromosome
  • spindle assembly checkpoint (sac)
    • Assembly
    • Spindle
    • Checkpoint
    • Regulation
    • Mitotic
    • Protein
    • Function
    • Bub3
    • Location
    • Proteins
    • Segregation
    • Bp
  • anaphase promoting complex (apc)
    • Inhibit
    • Cdc20
    • Formation
    • Securin
    • Bub1
    • Bubr1
    • Complex
    • Proteins
    • Mitotic
    • Sac
    • Spindle
    • Binding
  • role in the spindle assembly checkpoint
    • Assembly
    • Spindle
    • Checkpoint
    • Regulation
    • Mitotic
    • Protein
    • Function
    • Bub3
    • Location
    • Proteins
    • Segregation
    • Bp
  • kinetochore
    • Localization
    • Attachment
    • Proteins
    • Segregation
    • Chromosome
    • Mitotic
    • Spindle
    • Bub1
    • Function
    • Regulation
    • Band
    • Binding
  • gene
    • Location
    • Human
    • Bp
    • Chr
    • Chromosome
    • Mitotic
    • Function
    • Regulation
    • Band
    • Cell
    • Protein
    • Assembly

Connections between topic areas Semantic bridges

For BUB3, one of the stronger structural bridges in this analysis connects BUB3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BUB3Overview · splits 25 ⟂ 9
BUB3Role in the spindle assembly checkpoint · splits 26 ⟂ 8
BUB3Function · splits 27 ⟂ 7
BUB3Interactions · splits 29 ⟂ 5
BUB3Structure · splits 30 ⟂ 4

Map overview Semantic statistics

BUB3

Nodes34
Edges33
Triples138
Avg. degree1.94
Density0.058824
Components1

Source & methodology

TTTA analyzes the structure around BUB3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in the spindle assembly checkpoint, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BUB3 · EN edition · Analysis: TopicsToTalkAbout

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