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BUB1

Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene.

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Function

16 related topics

Structure

6 related topics

Subcellular location

3 related topics

Implications in cancer

3 related topics

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2.7.11.1
Aliases
BUB1, BUB1A, BUB1L, hBUB1 mitotic checkpoint serine/threonine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LAH, 4A1G, 4QPM, 4R8Q, 5DMZ
Band
2q13 · 2 F1|2 62.1 cM
Bgee
ventricular zone · gonad · ganglionic eminence · right testis · left testis
BioGPS
More reference expression data

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Overview

Structure

Subcellular location

Function

Implications in cancer

Link to caspase-independent mitotic death (CIMD)

Advanced semantic analysis

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Map overview Semantic statistics

BUB1

Nodes46
Edges45
Triples141
Avg. degree1.96
Density0.043478
Components1

How this topic connects Entity context

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BUB1

Top relations

Gene ontology · 28
BUB1 → apoptotic process, ATP binding, cell cycle, cell division, cell population proliferation, chromosome, chromosome segregation, chromosome, centromeric region, cytosol, kinase activity, kinetochore, meiotic sister chromatid cohesion, centromeric, membrane, mitotic cell cycle checkpoint signaling, mitotic spindle assembly checkpoint signaling, nucleoplasm, nucleotide binding, nucleus, phosphorylation, protein binding
Bgee · 20
BUB1 → abdominal wall, bone marrow cell, dermis, epiblast, ganglionic eminence, genital tubercle, gonad, left testis, mandibular prominence, maxillary prominence, mucosa of transverse colon, otic placode, primitive streak, right testis, secondary oocyte, spermatid, tail of embryo, testicle, trabecular bone, ventricular zone
RNA expression pattern · 20
BUB1 → abdominal wall, bone marrow cell, dermis, epiblast, ganglionic eminence, genital tubercle, gonad, left testis, mandibular prominence, maxillary prominence, mucosa of transverse colon, otic placode, primitive streak, right testis, secondary oocyte, spermatid, tail of embryo, testicle, trabecular bone, ventricular zone
related to Function · 12
BUB1 → At, BUB3, Figure, In, Mad1, MAD2, MAD3/BubR1, Metaphase-to-anaphase, Mps1, SAC, Several, The
related to Implications in cancer · 10
BUB1 → Disturbed, For, HeLa, In, Indications, Loss-of-function, More, Moreover, SV-40, Whether
related to Structure · 10
BUB1 → AF15q14, Bub1p, C-terminal, Hs-BUB1, N-terminal, SAC, The, The ATP, The N-terminal, TPR
related to Link to caspase-independent mitotic death (CIMD) · 9
BUB1 → BubR1, CIMD, Depletion, Direct, However, It, Recently Bub1, SAC, The
related to Subcellular location · 4
BUB1 → During, G1, G2/M, In
Band · 2
BUB1 → 2 F1|2 62.1 cM, 2q13
Chr. · 2
BUB1 → Chromosome 2 (human), Chromosome 2 (mouse)

Important terminology Word statistics

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Important terminology

kinase mitotic checkpoint human chromosome kinetochore also sac bp gene protein identified serine spindle chr band location activity phosphorylation aneuploidy

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BUB12.7.11.11.00infobox
BUB1AliasesBUB1, BUB1A, BUB1L, hBUB1 mitotic checkpoint serine/threonine kinase1.00infobox
BUB1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LAH, 4A1G, 4QPM, 4R8Q, 5DMZ1.00infobox
BUB1Band2q131.00infobox
BUB1Band2 F1|2 62.1 cM1.00infobox
BUB1Bgeeventricular zone1.00infobox
BUB1Bgeegonad1.00infobox
BUB1Bgeeganglionic eminence1.00infobox
BUB1Bgeeright testis1.00infobox
BUB1Bgeeleft testis1.00infobox
BUB1Bgeesecondary oocyte1.00infobox
BUB1Bgeetesticle1.00infobox
BUB1Bgeebone marrow cell1.00infobox
BUB1Bgeemucosa of transverse colon1.00infobox
BUB1Bgeetrabecular bone1.00infobox
BUB1Bgeetail of embryo1.00infobox
BUB1Bgeegenital tubercle1.00infobox
BUB1Bgeeabdominal wall1.00infobox
BUB1Bgeeepiblast1.00infobox
BUB1Bgeeprimitive streak1.00infobox
BUB1Bgeeotic placode1.00infobox
BUB1Bgeemandibular prominence1.00infobox
BUB1Bgeedermis1.00infobox
BUB1Bgeemaxillary prominence1.00infobox
BUB1Bgeespermatid1.00infobox
BUB1BioGPSMore reference expression data1.00infobox
BUB1Chr.Chromosome 2 (human)1.00infobox
BUB1Chr.Chromosome 2 (mouse)1.00infobox
BUB1DatabasesNCBI: entry; OMA: entry1.00infobox
BUB1End110,678,063 bp1.00infobox

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