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Mad2

Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons.…

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Future work

3 related topics

Mad2 conformers

4 related topics

Metaphase-to-anaphase transition

2 related topics

Overview

10 related topics

Key facts & relationships

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Alt. symbols
YJL030W
Chromosome
X: 0.39 - 0.39 Mb
Domains
InterPro
Entrez
853422
Organism
S. cerevisiae S288c
Orthologs
NCBI: entry; OMA: entry

Topics to explore

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Overview

Metaphase-to-anaphase transition

Mad2 conformers

Future work

Advanced semantic analysis

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Map overview Semantic statistics

Mad2

Nodes24
Edges23
Triples50
Avg. degree1.92
Density0.083333
Components1

How this topic connects Entity context

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Mad2

Top relations

related to Future work · 13
Mad2 → Bub1, Bub3, BubR1, Cdc20, Closed Mad2, De Antoni, It, Mad1, Mad2 Template, Mad2-Cdc20, Much, Open Mad2, Testing
related to Mad2 activation in the spindle assembly checkpoint · 13
Mad2 → Cdc20, Closed Mad2, Closed-Mad2-Mad1, Given, In, Mad, Mad1, Mad1-Mad2, Open Mad2, SAC, Since, This Mad1, When
related to Mad2 conformers · 8
Mad2 → Binding, C-terminal, Cdc20, In, Mad1, Open Mad2, This, Upon
Alt. symbols · 1
Mad2 → YJL030W
Chromosome · 1
Mad2 → X: 0.39 - 0.39 Mb
Domains · 1
Mad2 → InterPro
Entrez · 1
Mad2 → 853422
Organism · 1
Mad2 → S. cerevisiae S288c
Orthologs · 1
Mad2 → NCBI: entry; OMA: entry
RefSeq (mRNA) · 1
Mad2 → NM_001181464

Important terminology Word statistics

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Important terminology

cdc20 checkpoint mad1 spindle protein binding transition open microtubule metaphase-to-anaphase anaphase kinetochores complex closed first cerevisiae sister bound proteins bind

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mad2Alt. symbolsYJL030W1.00infobox
Mad2ChromosomeX: 0.39 - 0.39 Mb1.00infobox
Mad2DomainsInterPro1.00infobox
Mad2Entrez8534221.00infobox
Mad2OrganismS. cerevisiae S288c1.00infobox
Mad2OrthologsNCBI: entry; OMA: entry1.00infobox
Mad2RefSeq (mRNA)NM_0011814641.00infobox
Mad2RefSeq (Prot)NP_0125041.00infobox
Mad2Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Mad2StructuresSwiss-model1.00infobox
Mad2SymbolMad21.00infobox
Mad2UniProtP409581.00infobox
Mad2is astable complex and Cdc20 and Mad1 bind Mad 2 in the very same binding site0.90text

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    Min side: 3
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