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Mad2: Works & Standards

Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons.…

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Mad2 topic overview

The analysis highlights Works and Standards as prominent areas in the source structure around Mad2.

Related topics
19
Source areas
4
Connected nodes
23
Extracted relationships
50
Concept neighborhoods
15
Bridge connections
23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 10 topics
Mad2 conformers · 4 topics
Future work · 3 topics
Metaphase-to-anaphase transition · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
YJL030W
Chromosome
X: 0.39 - 0.39 Mb
Domains
InterPro
Entrez
853422
Organism
S. cerevisiae S288c
Orthologs
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Metaphase-to-anaphase transition

Mad2 conformers

Future work

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mad2 connects Entity context

The extracted context around Mad2 shows recurring relationship patterns in the source. For example, Mad2 → Bub1, Bub3, BubR1, Cdc20, Closed Mad2, De Antoni, It, Mad1, Mad2 Template, Mad2-Cdc20, Much, Open Mad2, Testing Another extracted example is Mad2 → Cdc20, Closed Mad2, Closed-Mad2-Mad1, Given, In, Mad, Mad1, Mad1-Mad2, Open Mad2, SAC, Since, This Mad1, When. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mad2

Top relations

related to Future work · 13
Mad2 → Bub1, Bub3, BubR1, Cdc20, Closed Mad2, De Antoni, It, Mad1, Mad2 Template, Mad2-Cdc20, Much, Open Mad2, Testing
related to Mad2 activation in the spindle assembly checkpoint · 13
Mad2 → Cdc20, Closed Mad2, Closed-Mad2-Mad1, Given, In, Mad, Mad1, Mad1-Mad2, Open Mad2, SAC, Since, This Mad1, When
related to Mad2 conformers · 8
Mad2 → Binding, C-terminal, Cdc20, In, Mad1, Open Mad2, This, Upon
Alt. symbols · 1
Mad2 → YJL030W
Chromosome · 1
Mad2 → X: 0.39 - 0.39 Mb
Domains · 1
Mad2 → InterPro
Entrez · 1
Mad2 → 853422
Organism · 1
Mad2 → S. cerevisiae S288c
Orthologs · 1
Mad2 → NCBI: entry; OMA: entry
RefSeq (mRNA) · 1
Mad2 → NM_001181464

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cdc20 checkpoint mad1 spindle protein binding transition open microtubule metaphase-to-anaphase anaphase kinetochores complex closed first cerevisiae sister bound proteins bind

Mad2 relationships Subject–Predicate–Object triples

TTTA extracted 50 structured relationships around Mad2. Examples in this analysis include Mad2 → Alt. symbols → YJL030W and Mad2 → Chromosome → X: 0.39 - 0.39 Mb. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mad2Alt. symbolsYJL030W1.00infobox
Mad2ChromosomeX: 0.39 - 0.39 Mb1.00infobox
Mad2DomainsInterPro1.00infobox
Mad2Entrez8534221.00infobox
Mad2OrganismS. cerevisiae S288c1.00infobox
Mad2OrthologsNCBI: entry; OMA: entry1.00infobox
Mad2RefSeq (mRNA)NM_0011814641.00infobox
Mad2RefSeq (Prot)NP_0125041.00infobox
Mad2Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Mad2StructuresSwiss-model1.00infobox
Mad2SymbolMad21.00infobox
Mad2UniProtP409581.00infobox
Mad2is astable complex and Cdc20 and Mad1 bind Mad 2 in the very same binding site0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mad2 bring nearby vocabulary together. In this analysis, examples include Cdc20, Mad1 and Binding. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Mad2
    • Cdc20
    • Mad1
    • Binding
    • Open
    • Closed
    • Bind
    • First
    • Complexes
    • Proteins
    • Complex
    • Kinetochores
    • Checkpoint
  • mad2
    • Cdc20
    • Mad1
    • Binding
    • Open
    • Closed
    • Bind
    • First
    • Complexes
    • Proteins
    • Complex
    • Kinetochores
    • Checkpoint
  • mad2 conformers
    • Cdc20
    • Mad1
    • Binding
    • Open
    • Closed
    • Bind
    • First
    • Complexes
    • Proteins
    • Complex
    • Kinetochores
    • Checkpoint
  • spindle checkpoint
    • Spindle
    • Assembly
    • Transition
    • Anaphase
    • Sister
    • Mitotic
    • Metaphase-to-anaphase
    • Cerevisiae
    • Search
    • Become
    • Metaphase
    • Remains
  • protein
    • Microtubule
    • Human
    • Kinetochore
    • Nocodazole
    • Search
    • Would
    • Yeast
    • Belt
    • First
    • Safety
    • Securin
    • Unattached
  • anaphase
    • Spindle
    • Assembly
    • Become
    • Sister
    • Checkpoint
    • Transition
    • Cerevisiae
    • Search
    • Activated
    • Cdc20
    • Metaphase
    • Sac
  • metaphase-to-anaphase transition
    • Transition
    • Anaphase
    • Spindle
    • Cerevisiae
    • Kinetochore
    • Nocodazole
    • Search
    • Assembly
    • Metaphase
    • Microtubule
    • Unattached
    • Complexes
  • s. cerevisiae
    • Search
    • Would
    • Yeast
    • Assembly
    • First
    • Metaphase
    • Microtubule
    • Metaphase-to-anaphase
    • Sister
    • Transition
    • Anaphase
    • Spindle

Connections between topic areas Semantic bridges

For Mad2, one of the stronger structural bridges in this analysis connects Mad2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Mad2 — Overview · splits 13 ⟂ 11
Mad2 — Mad2 conformers · splits 19 ⟂ 5
Mad2 — Future work · splits 20 ⟂ 4
Mad2 — Metaphase-to-anaphase transition · splits 21 ⟂ 3

Map overview Semantic statistics

Mad2

Nodes24
Edges23
Triples50
Avg. degree1.92
Density0.083333
Components1

Source & methodology

TTTA analyzes the structure around Mad2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Works & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mad2 · EN edition · Analysis: TopicsToTalkAbout

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