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Thermolysin: Applications, Structure & Synthesis

Thermolysin (EC 3.4.24.27, Bacillus thermoproteolyticus neutral proteinase, thermoase, thermoase Y10, TLN) is a thermostable neutral metalloproteinase enzyme produced by the Gram-positive bacteria Bacillus thermoproteolyticus. It requires one zinc ion for enzyme activity and four calcium ions for structural stability. Thermolysin specifically catalyzes…

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Thermolysin topic overview

The analysis highlights Applications, Structure and Synthesis as prominent areas in the source structure around Thermolysin.

Related topics
34
Source areas
4
Connected nodes
38
Extracted relationships
42
Concept neighborhoods
22
Bridge connections
38

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 13 topics
Overview · 11 topics
Synthesis · 8 topics
Applications · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
9073-78-3
EC no.
3.4.24.27
ExPASy
NiceZyme view
KEGG
enzyme entry
MetaCyc
metabolic pathway

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Synthesis

Structure

Applications

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Thermolysin connects Entity context

The extracted context around Thermolysin shows recurring relationship patterns in the source. For example, Thermolysin → At, Bacillus, C-terminal, Changing, Da, F63, However, In, Its, N-terminal, P69, Preventing, Studies, T50, The, These, TLP, TLP-ste Another extracted example is Thermolysin → M04, Medicine Medical Subject Headings, MeSH, National Library, The MEROPS. Use these groups to spot repeated connection types before inspecting the individual relationships.

Thermolysin

Top relations

related to Structure · 18
Thermolysin → At, Bacillus, C-terminal, Changing, Da, F63, However, In, Its, N-terminal, P69, Preventing, Studies, T50, The, These, TLP, TLP-ste
related to External links · 5
Thermolysin → M04, Medicine Medical Subject Headings, MeSH, National Library, The MEROPS
has application · 3
Thermolysin → Determining, FASTpp, In
related to Synthesis · 3
Thermolysin → In, Like, The
BRENDA · 1
Thermolysin → enzyme data
CAS no. · 1
Thermolysin → 9073-78-3
EC no. · 1
Thermolysin → 3.4.24.27
ExPASy · 1
Thermolysin → NiceZyme view
KEGG · 1
Thermolysin → enzyme entry
MetaCyc · 1
Thermolysin → metabolic pathway

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

stability bacillus enzyme amino peptide calcium acids produced structure hydrolysis stable family also proteins 24 27 thermoproteolyticus signal mature molecule

Thermolysin relationships Subject–Predicate–Object triples

TTTA extracted 42 structured relationships around Thermolysin. Examples in this analysis include Thermolysin → BRENDA → enzyme data and Thermolysin → CAS no. → 9073-78-3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ThermolysinBRENDAenzyme data1.00infobox
ThermolysinCAS no.9073-78-31.00infobox
ThermolysinEC no.3.4.24.271.00infobox
ThermolysinExPASyNiceZyme view1.00infobox
ThermolysinKEGGenzyme entry1.00infobox
ThermolysinMetaCycmetabolic pathway1.00infobox
ThermolysinNCBIproteins1.00infobox
ThermolysinPDB structuresRCSB PDB PDBe PDBsum1.00infobox
ThermolysinPMCarticles1.00infobox
ThermolysinPubMedarticles1.00infobox
ThermolysinRheareactions1.00infobox
ThermolysinSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox
Thermolysinis amost stable member of a family of metalloproteinases produced by various Bacillus species0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Thermolysin bring nearby vocabulary together. In this analysis, examples include Amino, Stability and Proteins. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Thermolysin
    • Amino
    • Stability
    • Proteins
    • Calcium
    • Enzyme
    • Produced
    • Acids
    • Peptide
    • Also
    • However
    • Hydrolysis
    • Member
  • thermolysin
    • Amino
    • Stability
    • Proteins
    • Calcium
    • Enzyme
    • Produced
    • Acids
    • Peptide
    • Also
    • However
    • Hydrolysis
    • Member
  • enzyme
    • Pre-proenzyme
    • Gram-positive
    • Metalloproteinase
    • Thermostable
    • Activity
    • Bacterial
    • Extracellular
    • Ion
    • Proteinase
    • Thermoproteolyticus
    • Mature
    • Proteins
  • hydrophobic amino acids
    • Acids
    • Amino
    • Stability
    • Peptide
    • Thermolysin
    • Domains
    • However
    • Hydrolysis
    • Pre-proenzyme
    • Proteinase
    • Mature
    • Proteins
  • bacillus
    • Produced
    • Proteinase
    • Thermoproteolyticus
    • Stable
    • Gram-positive
    • Metalloproteinase
    • Thermostable
    • Member
    • Synthesis
    • Family
    • Structure
    • Thermolysin
  • peptide bonds
    • Acts
    • Bond
    • Mature
    • Signal
    • Acids
    • Amino
    • Also
    • Bacterial
    • However
    • Molecular
    • Pre-proenzyme
    • Pre-prothermolysin
  • signal peptide
    • Pre-prothermolysin
    • Acts
    • Bond
    • Mature
    • Signal
    • Acids
    • Amino
    • Also
    • Bacterial
    • However
    • Molecular
    • Pre-proenzyme
  • calcium ions
    • Ion
    • Stability
    • Molecule
    • However
    • Proteins
    • Thermolysin
    • Enzyme
    • Acids
    • Amino

Connections between topic areas Semantic bridges

For Thermolysin, one of the stronger structural bridges in this analysis connects Thermolysin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ThermolysinStructure · splits 25 ⟂ 14
ThermolysinOverview · splits 27 ⟂ 12
ThermolysinSynthesis · splits 30 ⟂ 9
ThermolysinApplications · splits 36 ⟂ 3

Map overview Semantic statistics

Thermolysin

Nodes39
Edges38
Triples42
Avg. degree1.95
Density0.051282
Components1

Source & methodology

TTTA analyzes the structure around Thermolysin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Structure & Synthesis, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thermolysin · EN edition · Analysis: TopicsToTalkAbout

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