Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Factor XII

Coagulation factor XII, also known as Hageman factor, is a plasma protein involved in coagulation. It is the zymogen form of factor XIIa (EC 3.4.21.38), an enzyme of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by F12 gene.

History & Products

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Factor XII. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.38
Aliases
F12, HAE3, HAEX, HAF, coagulation factor XII
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BDW, 4BDX, 4XDE, 4XE4
Band
5q35.3 · 13|13 B1
Bgee
right lobe of liver · gingival epithelium · mucosa of transverse colon · testicle · endothelial cell
BioGPS
More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Genetics

Structure

Function

Clinical significance

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Factor XII

Nodes53
Edges52
Triples161
Avg. degree1.96
Density0.037736
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Factor XII

Top relations

Gene ontology · 29
Factor XII → blood coagulation, blood coagulation, intrinsic pathway, calcium ion binding, collagen-containing extracellular matrix, extracellular exosome, extracellular region, extracellular space, Factor XII activation, fibrinolysis, hemostasis, hydrolase activity, innate immune response, misfolded protein binding, peptidase activity, plasma kallikrein-kinin cascade, plasma membrane, positive regulation of blood coagulation, positive regulation of fibrinolysis, positive regulation of plasminogen activation, protein autoprocessing
Bgee · 20
Factor XII → abdominal wall, caudate nucleus, embryo, endothelial cell, epithelium of esophagus, fetal liver hematopoietic progenitor cell, gingival epithelium, granulocyte, human fetus, left lobe of liver, lobe of liver, middle temporal gyrus, morula, mucosa of transverse colon, nucleus accumbens, putamen, right lobe of liver, sexually immature organism, spermatid, testicle
RNA expression pattern · 20
Factor XII → abdominal wall, caudate nucleus, embryo, endothelial cell, epithelium of esophagus, fetal liver hematopoietic progenitor cell, gingival epithelium, granulocyte, human fetus, left lobe of liver, lobe of liver, middle temporal gyrus, morula, mucosa of transverse colon, nucleus accumbens, putamen, right lobe of liver, sexually immature organism, spermatid, testicle
related to External links · 17
Factor XII → Archived, Coagulation, Factor, Medicine Medical Subject Headings, MeSH, National Library, October, Overview, P00748, PDB, PDBe-KB, S01, Summary, The MEROPS, UniProt, XII, XIIa
related to history · 17
Factor XII → Also, Currently, Hageman, Hageman's, Hepatocytes, However, John Hageman, Oscar Ratnoff, Paradoxically, QuikClot, Ratnoff, Since, The, These, This, TV, XII
related to Structure · 12
Factor XII → Arg334, Arg353, Crystal, FnI-EGF-like, FXII, FXIIa, Human Factor XII, II, It, The, X-ray, XII
related to Function · 9
Factor XII → Activated, FXII, FXIIa, Hageman, In, It, Polyphosphates, Various, XI
related to Clinical significance · 8
Factor XII → All, As, Fletcher, Mice, The, Unlike, XI, XII
Band · 2
Factor XII → 13|13 B1, 5q35.3
Chr. · 2
Factor XII → Chromosome 13 (mouse), Chromosome 5 (human)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

factor xii coagulation fxii gene bp human also blood chr chromosome band thrombosis deficiency time hageman mouse f12 quikclot activated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Factor XII3.4.21.381.00infobox
Factor XIIAliasesF12, HAE3, HAEX, HAF, coagulation factor XII1.00infobox
Factor XIIAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BDW, 4BDX, 4XDE, 4XE41.00infobox
Factor XIIBand5q35.31.00infobox
Factor XIIBand13|13 B11.00infobox
Factor XIIBgeeright lobe of liver1.00infobox
Factor XIIBgeegingival epithelium1.00infobox
Factor XIIBgeemucosa of transverse colon1.00infobox
Factor XIIBgeetesticle1.00infobox
Factor XIIBgeeendothelial cell1.00infobox
Factor XIIBgeemiddle temporal gyrus1.00infobox
Factor XIIBgeeepithelium of esophagus1.00infobox
Factor XIIBgeenucleus accumbens1.00infobox
Factor XIIBgeecaudate nucleus1.00infobox
Factor XIIBgeeputamen1.00infobox
Factor XIIBgeelobe of liver1.00infobox
Factor XIIBgeeleft lobe of liver1.00infobox
Factor XIIBgeegranulocyte1.00infobox
Factor XIIBgeemorula1.00infobox
Factor XIIBgeeembryo1.00infobox
Factor XIIBgeefetal liver hematopoietic progenitor cell1.00infobox
Factor XIIBgeespermatid1.00infobox
Factor XIIBgeesexually immature organism1.00infobox
Factor XIIBgeeabdominal wall1.00infobox
Factor XIIBgeehuman fetus1.00infobox
Factor XIIBioGPSMore reference expression data1.00infobox
Factor XIIChr.Chromosome 5 (human)1.00infobox
Factor XIIChr.Chromosome 13 (mouse)1.00infobox
Factor XIIDatabasesNCBI: entry; OMA: entry1.00infobox
Factor XIIEnd177,416,583 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.