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Coagulation factor XII, also known as Hageman factor, is a plasma protein involved in coagulation. It is the zymogen form of factor XIIa (EC 3.4.21.38), an enzyme of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by F12 gene.
The analysis highlights History and Products as prominent areas in the source structure around Factor XII.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Factor XII shows recurring relationship patterns in the source. For example, Factor XII → blood coagulation, blood coagulation, intrinsic pathway, calcium ion binding, collagen-containing extracellular matrix, extracellular exosome, extracellular region, extracellular space, Factor XII activation, fibrinolysis, hemostasis, hydrolase activity, innate immune response, misfolded protein binding, peptidase activity, plasma kallikrein-kinin cascade, plasma membrane, positive regulation of blood coagulation, positive regulation of fibrinolysis, positive regulation of plasminogen activation, protein autoprocessing Another extracted example is Factor XII → abdominal wall, caudate nucleus, embryo, endothelial cell, epithelium of esophagus, fetal liver hematopoietic progenitor cell, gingival epithelium, granulocyte, human fetus, left lobe of liver, lobe of liver, middle temporal gyrus, morula, mucosa of transverse colon, nucleus accumbens, putamen, right lobe of liver, sexually immature organism, spermatid, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
factor xii coagulation fxii gene bp human also blood chr chromosome band thrombosis deficiency time hageman mouse f12 quikclot activated
TTTA extracted 161 structured relationships around Factor XII. Examples in this analysis include Factor XII → 3.4.21.38 → ↗ and Factor XII → Aliases → F12, HAE3, HAEX, HAF, coagulation factor XII. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Factor XII | 3.4.21.38 | ↗ | 1.00 | infobox |
| Factor XII | Aliases | F12, HAE3, HAEX, HAF, coagulation factor XII | 1.00 | infobox |
| Factor XII | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BDW, 4BDX, 4XDE, 4XE4 | 1.00 | infobox |
| Factor XII | Band | 5q35.3 | 1.00 | infobox |
| Factor XII | Band | 13|13 B1 | 1.00 | infobox |
| Factor XII | Bgee | right lobe of liver | 1.00 | infobox |
| Factor XII | Bgee | gingival epithelium | 1.00 | infobox |
| Factor XII | Bgee | mucosa of transverse colon | 1.00 | infobox |
| Factor XII | Bgee | testicle | 1.00 | infobox |
| Factor XII | Bgee | endothelial cell | 1.00 | infobox |
| Factor XII | Bgee | middle temporal gyrus | 1.00 | infobox |
| Factor XII | Bgee | epithelium of esophagus | 1.00 | infobox |
| Factor XII | Bgee | nucleus accumbens | 1.00 | infobox |
| Factor XII | Bgee | caudate nucleus | 1.00 | infobox |
| Factor XII | Bgee | putamen | 1.00 | infobox |
| Factor XII | Bgee | lobe of liver | 1.00 | infobox |
| Factor XII | Bgee | left lobe of liver | 1.00 | infobox |
| Factor XII | Bgee | granulocyte | 1.00 | infobox |
| Factor XII | Bgee | morula | 1.00 | infobox |
| Factor XII | Bgee | embryo | 1.00 | infobox |
| Factor XII | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| Factor XII | Bgee | spermatid | 1.00 | infobox |
| Factor XII | Bgee | sexually immature organism | 1.00 | infobox |
| Factor XII | Bgee | abdominal wall | 1.00 | infobox |
| Factor XII | Bgee | human fetus | 1.00 | infobox |
| Factor XII | BioGPS | More reference expression data | 1.00 | infobox |
| Factor XII | Chr. | Chromosome 5 (human) | 1.00 | infobox |
| Factor XII | Chr. | Chromosome 13 (mouse) | 1.00 | infobox |
| Factor XII | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Factor XII | End | 177,416,583 bp | 1.00 | infobox |
The concept neighborhoods around Factor XII bring nearby vocabulary together. In this analysis, examples include Xii, Deficiency and Clotting. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Factor XII, one of the stronger structural bridges in this analysis connects Factor XII with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Factor XII to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Factor XII · EN edition · Analysis: TopicsToTalkAbout