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Factor VII: Applications & Products

Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is a protein involved in coagulation and, in humans, is encoded by gene F7. It is an enzyme of the serine protease class. Once bound to tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor…

Language: English [EN]
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Factor VII topic overview

The analysis highlights Applications and Products as prominent areas in the source structure around Factor VII.

Related topics
30
Source areas
6
Connected nodes
36
Extracted relationships
160
Concept neighborhoods
19
Bridge connections
36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 15 topics
Physiology · 8 topics
Medical uses · 3 topics
Role in disease · 2 topics
Genetics · 1 topics
Interactions · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.21
Aliases
F7, SPCA, coagulation factor VII
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YT7, 1BF9, 1CVW, 1DAN, 1DVA, 1F7E, 1F7M, 1FAK, 1FF7, 1FFM, 1J9C, 1JBU, 1KLI, 1KLJ, 1O5D, 1QFK, 1W0Y, 1W2K,…
Band
13q34 · 8 A1.1|8 5.73 cM
Bgee
right lobe of liver · tendon of biceps brachii · testicle · ventral tegmental area · secondary oocyte
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Physiology

Genetics

Role in disease

Medical uses

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Factor VII connects Entity context

The extracted context around Factor VII shows recurring relationship patterns in the source. For example, Factor VII → animal organ regeneration, blood coagulation, blood coagulation, extrinsic pathway, calcium ion binding, circadian rhythm, collagen-containing extracellular matrix, endopeptidase activity, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, extracellular region, extracellular space, Golgi lumen, hemostasis, hydrolase activity, peptidase activity, plasma membrane, positive regulation of blood coagulation, positive regulation of cell migration, positive regulation of leukocyte chemotaxis, positive regulation of platelet-derived growth factor receptor signaling pathway Another extracted example is Factor VII → carotid body, choroid plexus of fourth ventricle, decidua, deltoid muscle, embryo, entorhinal cortex, Ileal epithelium, jejunum, left lobe of liver, pancreatic ductal cell, retinal pigment epithelium, right lobe of liver, right lung lobe, secondary oocyte, stroma of bone marrow, tendon of biceps brachii, testicle, ventral tegmental area, visceral pleura, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Factor VII

Top relations

Gene ontology · 48
Factor VII → animal organ regeneration, blood coagulation, blood coagulation, extrinsic pathway, calcium ion binding, circadian rhythm, collagen-containing extracellular matrix, endopeptidase activity, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, extracellular region, extracellular space, Golgi lumen, hemostasis, hydrolase activity, peptidase activity, plasma membrane, positive regulation of blood coagulation, positive regulation of cell migration, positive regulation of leukocyte chemotaxis, positive regulation of platelet-derived growth factor receptor signaling pathway
Bgee · 20
Factor VII → carotid body, choroid plexus of fourth ventricle, decidua, deltoid muscle, embryo, entorhinal cortex, Ileal epithelium, jejunum, left lobe of liver, pancreatic ductal cell, retinal pigment epithelium, right lobe of liver, right lung lobe, secondary oocyte, stroma of bone marrow, tendon of biceps brachii, testicle, ventral tegmental area, visceral pleura, yolk sac
RNA expression pattern · 20
Factor VII → carotid body, choroid plexus of fourth ventricle, decidua, deltoid muscle, embryo, entorhinal cortex, Ileal epithelium, jejunum, left lobe of liver, pancreatic ductal cell, retinal pigment epithelium, right lobe of liver, right lung lobe, secondary oocyte, stroma of bone marrow, tendon of biceps brachii, testicle, ventral tegmental area, visceral pleura, yolk sac
related to Physiology · 19
Factor VII → FVII, FVIIa, FVIIa-TF, IIa, IX, IXa, K-dependent, Once, TF, TF/factor III, TFPI, The, Tissue, Upon, Use, VII, VIIa, Xa, XIIa
related to Medical uses · 12
Factor VII → AryoSeven, Factor VIII, However, In, Israeli, It, IX, NovoSeven, Recombinant, Risks, The, VIIa
related to External links · 7
Factor VII → Archived, Comprehensive Health Education Services, LLC, MEROPS, Official, S01, Wayback MachineCHES
related to Role in disease · 6
Factor VII → AryoSeven, FVII, Gene, It, NovoSeven, VIIa
Band · 2
Factor VII → 13q34, 8 A1.1|8 5.73 cM
Chr. · 2
Factor VII → Chromosome 13 (human), Chromosome 8 (mouse)
End · 2
Factor VII → 113,120,685 bp, 13,085,809 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

factor vii coagulation gene tissue bp human eptacog chr band protein viia recombinant chromosome 13 activated ix fvii bleeding xa

Factor VII relationships Subject–Predicate–Object triples

TTTA extracted 160 structured relationships around Factor VII. Examples in this analysis include Factor VII → 3.4.21.21 → ↗ and Factor VII → Aliases → F7, SPCA, coagulation factor VII. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Factor VII3.4.21.211.00infobox
Factor VIIAliasesF7, SPCA, coagulation factor VII1.00infobox
Factor VIIAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YT7, 1BF9, 1CVW, 1DAN, 1DVA, 1F7E, 1F7M, 1FAK, 1FF7, 1FFM, 1J9C, 1JBU, 1KLI, 1KLJ, 1O5D, 1QFK, 1W0Y, 1W2K,…1.00infobox
Factor VIIBand13q341.00infobox
Factor VIIBand8 A1.1|8 5.73 cM1.00infobox
Factor VIIBgeeright lobe of liver1.00infobox
Factor VIIBgeetendon of biceps brachii1.00infobox
Factor VIIBgeetesticle1.00infobox
Factor VIIBgeeventral tegmental area1.00infobox
Factor VIIBgeesecondary oocyte1.00infobox
Factor VIIBgeevisceral pleura1.00infobox
Factor VIIBgeepancreatic ductal cell1.00infobox
Factor VIIBgeedeltoid muscle1.00infobox
Factor VIIBgeejejunum1.00infobox
Factor VIIBgeeretinal pigment epithelium1.00infobox
Factor VIIBgeeleft lobe of liver1.00infobox
Factor VIIBgeeright lung lobe1.00infobox
Factor VIIBgeeyolk sac1.00infobox
Factor VIIBgeedecidua1.00infobox
Factor VIIBgeeembryo1.00infobox
Factor VIIBgeeentorhinal cortex1.00infobox
Factor VIIBgeestroma of bone marrow1.00infobox
Factor VIIBgeecarotid body1.00infobox
Factor VIIBgeeIleal epithelium1.00infobox
Factor VIIBgeechoroid plexus of fourth ventricle1.00infobox
Factor VIIBioGPSMore reference expression data1.00infobox
Factor VIIChr.Chromosome 13 (human)1.00infobox
Factor VIIChr.Chromosome 8 (mouse)1.00infobox
Factor VIIDatabasesNCBI: entry; OMA: entry1.00infobox
Factor VIIEnd113,120,685 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Factor VII bring nearby vocabulary together. In this analysis, examples include Vii, Tissue and Recombinant. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Factor VII
    • Vii
    • Tissue
    • Recombinant
    • Viia
    • Blood
    • Complex
    • Ix
    • Role
    • Xa
    • Gene
    • Aryoseven
    • F7
  • factor vii
    • Vii
    • Tissue
    • Role
    • Recombinant
    • Viia
    • Chromosome
    • Human
    • Blood
    • Complex
    • Ix
    • Xa
    • Gene
  • coagulation
    • Factor
    • F7
    • Pathway
    • Role
    • Gene
    • Vii
    • Tissue
    • Enzyme
    • Location
    • Used
    • Blood
    • Hemorrhage
  • tissue factor
    • Blood
    • Vii
    • Tissue
    • Pathway
    • Receptor
    • Recombinant
    • Viia
    • Complex
    • Ix
    • Role
    • Xa
    • Gene
  • factor ix
    • Vii
    • Viia
    • Tissue
    • Recombinant
    • Blood
    • Complex
    • Ix
    • Role
    • Xa
    • Aryoseven
    • Gene
    • Novoseven
  • factor x
    • Vii
    • Tissue
    • Recombinant
    • Viia
    • Blood
    • Complex
    • Ix
    • Role
    • Xa
    • Gene
    • Aryoseven
    • F7
  • recombinant factor viia
    • Aryoseven
    • Novoseven
    • Vii
    • Viia
    • Tissue
    • Hemorrhage
    • Role
    • Recombinant
    • Blood
    • Complex
    • Ix
    • Xa
  • tissue factor pathway inhibitor
    • Blood
    • Vii
    • Tissue
    • Pathway
    • Receptor
    • Recombinant
    • Viia
    • Complex
    • Location
    • Ix
    • Role
    • Xa

Connections between topic areas Semantic bridges

For Factor VII, one of the stronger structural bridges in this analysis connects Factor VII with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Factor VIIOverview · splits 21 ⟂ 16
Factor VIIPhysiology · splits 28 ⟂ 9
Factor VIIMedical uses · splits 33 ⟂ 4
Factor VIIRole in disease · splits 34 ⟂ 3

Map overview Semantic statistics

Factor VII

Nodes37
Edges36
Triples160
Avg. degree1.95
Density0.054054
Components1

Source & methodology

TTTA analyzes the structure around Factor VII to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Factor VII · EN edition · Analysis: TopicsToTalkAbout

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