TMPRSS2

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Explore the main themes, entities and connections around TMPRSS2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Clinical significance

ETS transcription factors ERG ETV1 Gene fusion Androgen receptor

21 related topics

Structure

Protease N-terminal domain Transmembrane domain C-terminal Catalytic triad

11 related topics

Function

Domain Low density lipoprotein receptor class A domain Scavenger receptor cysteine-rich domain Pathological processes Androgenic hormones

8 related topics

Overview

Enzyme Gene TMPRSS Transmembrane proteins Serine protease

14 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.122: ↗
Aliases: TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 2
Band: 21q22.3 · 16 C4|16 57.53 cM
Bgee: mucosa of transverse colon · mucosa of sigmoid colon · body of pancreas · rectum · prostate
BioGPS: More reference expression data
Chr.: Chromosome 21 (human) · Chromosome 16 (mouse)

Topics to explore

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Inhibitors

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Map overview Semantic statistics

Nodes63

Edges62

Triples119

Avg. degree1.97

Density0.031746

Components1

How this topic connects Entity context

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TMPRSS2

Top relations

Bgee · 19

TMPRSS2 → body of pancreas, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, left colon, medullary collecting duct, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, olfactory zone of nasal mucosa, Paneth cell, parotid gland, prostate, pyloric antrum, pylorus, rectum, transitional epithelium of urinary bladder, yolk sac

RNA expression pattern · 19

Gene ontology · 18

TMPRSS2 → endocytosis, extracellular exosome, extracellular region, hydrolase activity, integral component of membrane, integral component of plasma membrane, membrane, peptidase activity, plasma membrane, positive regulation of viral entry into host cell, protein autoprocessing, protein binding, proteolysis, receptor-mediated endocytosis, scavenger receptor activity, serine-type endopeptidase activity, serine-type peptidase activity, vesicle-mediated transport

related to Structure · 15

TMPRSS2 → As, Asp345, C-terminal, Experimental, His296, II, Interestingly, LDLRA, N-terminal, S1/S2, SARS-CoV-2, Ser441, SP, SRCR, This

related to Coronaviruses · 9

TMPRSS2 → ACE2, Cleavage, Hydroxychloroquine, MERS-CoV, SARS-CoV, SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 S2, Some

related to Function · 6

TMPRSS2 → Gene, II, Serine, The, The TMPRSS2, This

related to Inhibitors · 5

TMPRSS2 → Camostat, COVID-19, It, N-0385, SARS-CoV-2

related to In prostate cancer · 4

TMPRSS2 → ERG, ETS, ETV1, TMPRSS2-ERG

Band · 2

TMPRSS2 → 16 C4|16 57.53 cM, 21q22.3

Chr. · 2

TMPRSS2 → Chromosome 16 (mouse), Chromosome 21 (human)

Important terminology Word statistics

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Important terminology

protease prostate sars-cov-2 gene activity protein serine bp domain transmembrane chr human band cells cancer receptor cell function 21 chromosome

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
TMPRSS2	3.4.21.122	↗	1.00	infobox
TMPRSS2	Aliases	TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 2	1.00	infobox
TMPRSS2	Band	21q22.3	1.00	infobox
TMPRSS2	Band	16 C4\|16 57.53 cM	1.00	infobox
TMPRSS2	Bgee	mucosa of transverse colon	1.00	infobox
TMPRSS2	Bgee	mucosa of sigmoid colon	1.00	infobox
TMPRSS2	Bgee	body of pancreas	1.00	infobox
TMPRSS2	Bgee	rectum	1.00	infobox
TMPRSS2	Bgee	prostate	1.00	infobox
TMPRSS2	Bgee	parotid gland	1.00	infobox
TMPRSS2	Bgee	duodenum	1.00	infobox
TMPRSS2	Bgee	mucosa of ileum	1.00	infobox
TMPRSS2	Bgee	olfactory zone of nasal mucosa	1.00	infobox
TMPRSS2	Bgee	pylorus	1.00	infobox
TMPRSS2	Bgee	Paneth cell	1.00	infobox
TMPRSS2	Bgee	transitional epithelium of urinary bladder	1.00	infobox
TMPRSS2	Bgee	left colon	1.00	infobox
TMPRSS2	Bgee	crypt of lieberkuhn of small intestine	1.00	infobox
TMPRSS2	Bgee	epithelium of stomach	1.00	infobox
TMPRSS2	Bgee	yolk sac	1.00	infobox
TMPRSS2	Bgee	mucous cell of stomach	1.00	infobox
TMPRSS2	Bgee	medullary collecting duct	1.00	infobox
TMPRSS2	Bgee	pyloric antrum	1.00	infobox
TMPRSS2	BioGPS	More reference expression data	1.00	infobox
TMPRSS2	Chr.	Chromosome 21 (human)	1.00	infobox
TMPRSS2	Chr.	Chromosome 16 (mouse)	1.00	infobox
TMPRSS2	Databases	NCBI: entry; OMA: entry	1.00	infobox
TMPRSS2	End	41,531,116 bp	1.00	infobox
TMPRSS2	End	97,412,395 bp	1.00	infobox
TMPRSS2	Ensembl	ENSG00000184012	1.00	infobox

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