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TMPRSS2: Regions, Clinical significance & Structure

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members are transmembrane proteins which have a serine protease activity. The TMPRSS2 protein is found in high concentration in the cell membranes of epithelial cells of the lung and of the prostate, but also in…

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TMPRSS2 topic overview

The analysis highlights Regions, Clinical significance and Structure as prominent areas in the source structure around TMPRSS2.

Related topics
57
Source areas
5
Connected nodes
62
Extracted relationships
119
Concept neighborhoods
23
Bridge connections
62

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 21 topics
Overview · 14 topics
Structure · 11 topics
Function · 8 topics
Inhibitors · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.122
↗
Aliases
TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 2
Band
21q22.3 · 16 C4|16 57.53 cM
Bgee
mucosa of transverse colon · mucosa of sigmoid colon · body of pancreas · rectum · prostate
BioGPS
More reference expression data
Chr.
Chromosome 21 (human) · Chromosome 16 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Clinical significance

Inhibitors

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TMPRSS2 connects Entity context

The extracted context around TMPRSS2 shows recurring relationship patterns in the source. For example, TMPRSS2 → body of pancreas, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, left colon, medullary collecting duct, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, olfactory zone of nasal mucosa, Paneth cell, parotid gland, prostate, pyloric antrum, pylorus, rectum, transitional epithelium of urinary bladder, yolk sac Another extracted example is TMPRSS2 → endocytosis, extracellular exosome, extracellular region, hydrolase activity, integral component of membrane, integral component of plasma membrane, membrane, peptidase activity, plasma membrane, positive regulation of viral entry into host cell, protein autoprocessing, protein binding, proteolysis, receptor-mediated endocytosis, scavenger receptor activity, serine-type endopeptidase activity, serine-type peptidase activity, vesicle-mediated transport. Use these groups to spot repeated connection types before inspecting the individual relationships.

TMPRSS2

Top relations

Bgee · 19
TMPRSS2 → body of pancreas, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, left colon, medullary collecting duct, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, olfactory zone of nasal mucosa, Paneth cell, parotid gland, prostate, pyloric antrum, pylorus, rectum, transitional epithelium of urinary bladder, yolk sac
RNA expression pattern · 19
TMPRSS2 → body of pancreas, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, left colon, medullary collecting duct, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, olfactory zone of nasal mucosa, Paneth cell, parotid gland, prostate, pyloric antrum, pylorus, rectum, transitional epithelium of urinary bladder, yolk sac
Gene ontology · 18
TMPRSS2 → endocytosis, extracellular exosome, extracellular region, hydrolase activity, integral component of membrane, integral component of plasma membrane, membrane, peptidase activity, plasma membrane, positive regulation of viral entry into host cell, protein autoprocessing, protein binding, proteolysis, receptor-mediated endocytosis, scavenger receptor activity, serine-type endopeptidase activity, serine-type peptidase activity, vesicle-mediated transport
related to Structure · 15
TMPRSS2 → As, Asp345, C-terminal, Experimental, His296, II, Interestingly, LDLRA, N-terminal, S1/S2, SARS-CoV-2, Ser441, SP, SRCR, This
related to Coronaviruses · 9
TMPRSS2 → ACE2, Cleavage, Hydroxychloroquine, MERS-CoV, SARS-CoV, SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 S2, Some
related to Function · 6
TMPRSS2 → Gene, II, Serine, The, The TMPRSS2, This
related to Inhibitors · 5
TMPRSS2 → Camostat, COVID-19, It, N-0385, SARS-CoV-2
related to In prostate cancer · 4
TMPRSS2 → ERG, ETS, ETV1, TMPRSS2-ERG
Band · 2
TMPRSS2 → 16 C4|16 57.53 cM, 21q22.3
Chr. · 2
TMPRSS2 → Chromosome 16 (mouse), Chromosome 21 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protease prostate sars-cov-2 gene activity protein serine bp domain transmembrane chr human band cells cancer receptor cell function 21 chromosome

TMPRSS2 relationships Subject–Predicate–Object triples

TTTA extracted 119 structured relationships around TMPRSS2. Examples in this analysis include TMPRSS2 → 3.4.21.122 → ↗ and TMPRSS2 → Aliases → TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TMPRSS23.4.21.122↗1.00infobox
TMPRSS2AliasesTMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 21.00infobox
TMPRSS2Band21q22.31.00infobox
TMPRSS2Band16 C4|16 57.53 cM1.00infobox
TMPRSS2Bgeemucosa of transverse colon1.00infobox
TMPRSS2Bgeemucosa of sigmoid colon1.00infobox
TMPRSS2Bgeebody of pancreas1.00infobox
TMPRSS2Bgeerectum1.00infobox
TMPRSS2Bgeeprostate1.00infobox
TMPRSS2Bgeeparotid gland1.00infobox
TMPRSS2Bgeeduodenum1.00infobox
TMPRSS2Bgeemucosa of ileum1.00infobox
TMPRSS2Bgeeolfactory zone of nasal mucosa1.00infobox
TMPRSS2Bgeepylorus1.00infobox
TMPRSS2BgeePaneth cell1.00infobox
TMPRSS2Bgeetransitional epithelium of urinary bladder1.00infobox
TMPRSS2Bgeeleft colon1.00infobox
TMPRSS2Bgeecrypt of lieberkuhn of small intestine1.00infobox
TMPRSS2Bgeeepithelium of stomach1.00infobox
TMPRSS2Bgeeyolk sac1.00infobox
TMPRSS2Bgeemucous cell of stomach1.00infobox
TMPRSS2Bgeemedullary collecting duct1.00infobox
TMPRSS2Bgeepyloric antrum1.00infobox
TMPRSS2BioGPSMore reference expression data1.00infobox
TMPRSS2Chr.Chromosome 21 (human)1.00infobox
TMPRSS2Chr.Chromosome 16 (mouse)1.00infobox
TMPRSS2DatabasesNCBI: entry; OMA: entry1.00infobox
TMPRSS2End41,531,116 bp1.00infobox
TMPRSS2End97,412,395 bp1.00infobox
TMPRSS2EnsemblENSG000001840121.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TMPRSS2 bring nearby vocabulary together. In this analysis, examples include Sars-cov-2, Prostate and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TMPRSS2
    • Sars-cov-2
    • Prostate
    • Gene
    • Activity
    • Function
    • Protein
    • Entry
    • Inhibitor
    • Cell
    • Cleavage
    • Ace2
    • Use
  • tmprss2
    • Sars-cov-2
    • Prostate
    • Gene
    • Activity
    • Function
    • Protein
    • Entry
    • Inhibitor
    • Cell
    • Cleavage
    • Ace2
    • Use
  • gene
    • Prostate
    • Location
    • Chromosome
    • Human
    • Bp
    • Cancer
    • Chr
    • Function
    • Tmprss2
    • Humans
    • Mouse
    • Serine
  • transmembrane proteins
    • Protease
    • Encoded
    • Serine
    • Enzyme
    • Activity
    • Domain
    • Belongs
    • Family
    • Gene
    • Humans
    • Location
    • Scavenger
  • serine protease
    • Serine
    • Activity
    • Transmembrane
    • Protein
    • Tmprss2
    • Belongs
    • Family
    • Domain
    • Receptor
    • Enzyme
    • Gene
    • Location
  • cell membranes
    • Protein
    • Entry
    • Found
    • Cells
    • Tmprss2
    • Family
    • Mouse
    • Process
    • Infection
    • Location
    • Prostate
    • Protease
  • prostate cancer
    • Cancer
    • Prostate
    • Function
    • Gene
    • Tmprss2
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Enzyme
    • Infection
  • androgen-independent prostate cancer
    • Cancer
    • Prostate
    • Function
    • Gene
    • Tmprss2
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Enzyme
    • Infection

Connections between topic areas Semantic bridges

For TMPRSS2, one of the stronger structural bridges in this analysis connects TMPRSS2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TMPRSS2 — Clinical significance · splits 41 ⟂ 22
TMPRSS2 — Overview · splits 48 ⟂ 15
TMPRSS2 — Structure · splits 51 ⟂ 12
TMPRSS2 — Function · splits 54 ⟂ 9
TMPRSS2 — Inhibitors · splits 59 ⟂ 4

Map overview Semantic statistics

TMPRSS2

Nodes63
Edges62
Triples119
Avg. degree1.97
Density0.031746
Components1

Source & methodology

TTTA analyzes the structure around TMPRSS2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TMPRSS2 · EN edition · Analysis: TopicsToTalkAbout

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