Angiotensin-converting enzyme 2

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Angiotensin-converting enzyme 2 topic overview

The analysis highlights Art, Clinical significance and Tissue distribution as prominent areas in the source structure around Angiotensin-converting enzyme 2.

Related topics: 89
Source areas: 5
Connected nodes: 94
Extracted relationships: 136
Concept neighborhoods: 32
Bridge connections: 94

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 28 topics

Overview · 21 topics

Tissue distribution · 19 topics

Structure · 12 topics

Function · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.17.23: ↗
Aliases: ACE2, ACEH, angiotensin I converting enzyme 2, ACE 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SCL, 1R42, 1R4L, 2AJF, 3D0G, 3D0H, 3D0I, 3KBH, 3SCI, 3SCJ, 3SCK
Band: Xp22.2 · X F5|X 76.12 cM
Bgee: mucosa of ileum · gallbladder · jejunal mucosa · duodenum · right testis
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Membrane Cell membrane
Intestines
Kidney
Testis
Gallbladder
Heart
Renin–angiotensin–aldosterone system
Substrate presentation
Hydrolysis
Angiotensin II
Vasoconstrictor
Peptide
Angiotensin (1–7) Angiotensin (1-7)
Vasodilator
Cardiovascular diseases Cardiovascular disease
Coronaviruses
HCoV-NL63
SARS-CoV
SARS-CoV-2
Biological receptor Receptor (biochemistry)

Tissue distribution

Structure

Function

Clinical significance

Coronaviruses Coronavirus
SARS
COVID-19
Spike protein Coronavirus spike protein
Endocytosis
Translocation Protein translocation
Endosomes Endosome
Endothelium
Downregulation Downregulation and upregulation
Myocarditis
TMPRSS2
Glycosylation
ACE inhibitors ACE inhibitor
Angiotensin II receptor blockers Angiotensin II receptor blocker
Systematic review
Meta-analysis
Missense variants Missense mutation
SARS-CoV-2 spike protein
Viral pneumonias Viral pneumonia
Piglet Piglet (animal)
Lipopolysaccharide
Acute respiratory distress syndrome
Blood flow Hemodynamics
Oxygenation Oxygen saturation (medicine)
Vero cells Vero cell
Fc-fusions Fusion protein
Multimers Multimer
Pulmonary arterial hypertension

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Angiotensin-converting enzyme 2 connects Entity context

The extracted context around Angiotensin-converting enzyme 2 shows recurring relationship patterns in the source. For example, Angiotensin-converting enzyme 2 → angiotensin maturation, angiotensin-mediated drinking behavior, blood vessel diameter maintenance, brush border membrane, carboxypeptidase activity, cell surface, cytoplasm, endopeptidase activity, exopeptidase activity, extracellular exosome, extracellular region, extracellular space, hydrolase activity, integral component of membrane, membrane, membrane raft, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity Another extracted example is Angiotensin-converting enzyme 2 → apex of heart, duodenum, epithelium of small intestine, esophagus, gallbladder, human kidney, Ileal epithelium, ileum, intestinal villus, jejunal mucosa, jejunum, left testis, left ventricle, migratory enteric neural crest cell, mucosa of ileum, mucosa of transverse colon, Paneth cell, right testis, stroma of kidney. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 40

Angiotensin-converting enzyme 2 → angiotensin maturation, angiotensin-mediated drinking behavior, blood vessel diameter maintenance, brush border membrane, carboxypeptidase activity, cell surface, cytoplasm, endopeptidase activity, exopeptidase activity, extracellular exosome, extracellular region, extracellular space, hydrolase activity, integral component of membrane, membrane, membrane raft, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity

Bgee · 19

Angiotensin-converting enzyme 2 → apex of heart, duodenum, epithelium of small intestine, esophagus, gallbladder, human kidney, Ileal epithelium, ileum, intestinal villus, jejunal mucosa, jejunum, left testis, left ventricle, migratory enteric neural crest cell, mucosa of ileum, mucosa of transverse colon, Paneth cell, right testis, stroma of kidney

RNA expression pattern · 19

related to Structure · 15

Angiotensin-converting enzyme 2 → ACE2, ADAM17, Aldosterone System, Angiotensin, C-terminal, Excess, II, It, M2, MasR, Membrane, N-terminal, RAAS, Renin, The

related to External links · 12

Angiotensin-converting enzyme 2 → ACE2, Angiotensin-converting, AT1, Human ACE2, Membranome, OPM, PDB, PDBe-KB, Q9BYF1, SARS-CoV-2, UCSC Genome Browser, UniProt

Band · 2

Angiotensin-converting enzyme 2 → X F5|X 76.12 cM, Xp22.2

Chr. · 2

Angiotensin-converting enzyme 2 → X chromosome (human), X chromosome (mouse)

End · 2

Angiotensin-converting enzyme 2 → 15,602,148 bp, 162,971,416 bp

3.4.17.23 · 1

Angiotensin-converting enzyme 2 → ↗

Aliases · 1

Angiotensin-converting enzyme 2 → ACE2, ACEH, angiotensin I converting enzyme 2, ACE 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ace2 mace2 angiotensin enzyme blood sars-cov-2 also pressure protein entry human membrane cells sace2 soluble domain ii covid-19 bp ace

Angiotensin-converting enzyme 2 relationships Subject–Predicate–Object triples

TTTA extracted 136 structured relationships around Angiotensin-converting enzyme 2. Examples in this analysis include Angiotensin-converting enzyme 2 → 3.4.17.23 → ↗ and Angiotensin-converting enzyme 2 → Aliases → ACE2, ACEH, angiotensin I converting enzyme 2, ACE 2. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Angiotensin-converting enzyme 2	3.4.17.23	↗	1.00	infobox
Angiotensin-converting enzyme 2	Aliases	ACE2, ACEH, angiotensin I converting enzyme 2, ACE 2	1.00	infobox
Angiotensin-converting enzyme 2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SCL, 1R42, 1R4L, 2AJF, 3D0G, 3D0H, 3D0I, 3KBH, 3SCI, 3SCJ, 3SCK	1.00	infobox
Angiotensin-converting enzyme 2	Band	Xp22.2	1.00	infobox
Angiotensin-converting enzyme 2	Band	X F5\|X 76.12 cM	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	mucosa of ileum	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	gallbladder	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	jejunal mucosa	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	duodenum	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	right testis	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	left testis	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	left ventricle	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	human kidney	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	mucosa of transverse colon	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	apex of heart	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	ileum	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	jejunum	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	epithelium of small intestine	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	intestinal villus	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	stroma of kidney	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	Ileal epithelium	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	migratory enteric neural crest cell	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	Paneth cell	1.00	infobox
Angiotensin-converting enzyme 2	Bgee	esophagus	1.00	infobox
Angiotensin-converting enzyme 2	BioGPS	More reference expression data	1.00	infobox
Angiotensin-converting enzyme 2	Chr.	X chromosome (human)	1.00	infobox
Angiotensin-converting enzyme 2	Chr.	X chromosome (mouse)	1.00	infobox
Angiotensin-converting enzyme 2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Angiotensin-converting enzyme 2	End	15,602,148 bp	1.00	infobox
Angiotensin-converting enzyme 2	End	162,971,416 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Angiotensin-converting enzyme 2 bring nearby vocabulary together. In this analysis, examples include Enzyme, Cells and Domain. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Angiotensin-converting enzyme 2
- Enzyme
- Cells
- Domain
- Membrane
- Sace2
- Soluble
- Adam17
- Mace2
- Activity
- Sars-cov-2
- Function
- Human
angiotensin-converting enzyme 2
- Enzyme
- Raas
- Domain
- Cells
- Mace2
- Pressure
- Angiotensin
- Renin
- Membrane
- Blood
- System
- Soluble
enzyme
- Raas
- Domain
- Mace2
- Cells
- Pressure
- Angiotensin
- Renin
- Membrane
- Blood
- System
- Soluble
- Adam17
membrane
- Blood
- Soluble
- Pressure
- Angiotensin
- Sace2
- Adam17
- Protein
- Activity
- Band
- Function
- Bp
- Cell
heart
- Mace2
- Binding
- Membrane
- Expression
- Viral
- Blood
- Activity
- Band
- Function
- Bp
- Cell
- Chr
renin–angiotensin–aldosterone system
- Renin
- System
- Pressure
- Ii
- Raas
- Blood
- Soluble
- Angiotensin
- Ace
- Adam17
- Enzyme
- Human
angiotensin ii
- Pressure
- Ii
- Blood
- Raas
- Renin
- System
- Ace
- Enzyme
- Human
- Mace2
- Activity
- Function
angiotensin (1–7)
- Pressure
- Ii
- Blood
- Raas
- Renin
- System
- Ace
- Enzyme
- Human
- Mace2
- Activity
- Function

Connections between topic areas Semantic bridges

For Angiotensin-converting enzyme 2, one of the stronger structural bridges in this analysis connects Angiotensin-converting enzyme 2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Angiotensin-converting enzyme 2 — Clinical significance · splits 66 ⟂ 29

Angiotensin-converting enzyme 2 — Overview · splits 73 ⟂ 22

Angiotensin-converting enzyme 2 — Tissue distribution · splits 75 ⟂ 20

Angiotensin-converting enzyme 2 — Structure · splits 82 ⟂ 13

Angiotensin-converting enzyme 2 — Function · splits 85 ⟂ 10

Map overview Semantic statistics

Angiotensin-converting enzyme 2

Nodes95

Edges94

Triples136

Avg. degree1.98

Density0.021053

Components1

Source & methodology

TTTA analyzes the structure around Angiotensin-converting enzyme 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Angiotensin-converting enzyme 2 · EN edition · Analysis: TopicsToTalkAbout