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Activity-regulated cytoskeleton-associated protein

Activity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene. The gene is believed to derive from a retrotransposon. The protein is found in the neurons of tetrapods and other animals where it can form virus-like capsids that transport RNA between neurons.

Gene, Signaling & Protein

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Aliases
ARC, Arg3.1, activity-regulated cytoskeleton-associated protein, activity regulated cytoskeleton associated protein, hArc
Band
8q24.3 · 15 D3|15 34.25 cM
Bgee
anterior pituitary · right frontal lobe · prefrontal cortex · cingulate gyrus · anterior cingulate cortex
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 15 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Gene

Trafficking

Protein

Knockouts

Signaling

Behavioral effects

Arc in insects

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Activity-regulated cytoskeleton-associated protein

Nodes95
Edges94
Triples111
Avg. degree1.98
Density0.021053
Components1

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Activity-regulated cytoskeleton-associated protein

Top relations

Gene ontology · 46
Activity-regulated cytoskeleton-associated protein → acrosomal vesicle, actin cytoskeleton, anterior/posterior pattern specification, cell cortex, cell junction, cell migration, cell projection, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytoskeleton organization, dendrite, dendritic spine, dendritic spine morphogenesis, early endosome membrane, endocytosis, endoderm development, endosome, extracellular vesicle, glutamatergic synapse
Bgee · 19
Activity-regulated cytoskeleton-associated protein → anterior cingulate cortex, anterior pituitary, Brodmann area 9, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, ganglionic eminence, hippocampus proper, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, seminiferous tubule, spermatid, spermatocyte, striatum of neuraxis, superior frontal gyrus, testicle, ventricular zone
RNA expression pattern · 19
Activity-regulated cytoskeleton-associated protein → anterior cingulate cortex, anterior pituitary, Brodmann area 9, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, ganglionic eminence, hippocampus proper, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, seminiferous tubule, spermatid, spermatocyte, striatum of neuraxis, superior frontal gyrus, testicle, ventricular zone
Band · 2
Activity-regulated cytoskeleton-associated protein → 15 D3|15 34.25 cM, 8q24.3
Chr. · 2
Activity-regulated cytoskeleton-associated protein → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
Activity-regulated cytoskeleton-associated protein → 142,614,479 bp, 74,544,419 bp
Aliases · 1
Activity-regulated cytoskeleton-associated protein → ARC, Arg3.1, activity-regulated cytoskeleton-associated protein, activity regulated cytoskeleton associated protein, hArc
BioGPS · 1
Activity-regulated cytoskeleton-associated protein → n/a
Databases · 1
Activity-regulated cytoskeleton-associated protein → NCBI: entry; OMA: entry
Ensembl · 1
Activity-regulated cytoskeleton-associated protein → ENSG00000198576

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Important terminology

arc protein gene mrna human activity bp band factor chr chromosome sites translated activated important signaling neuronal synaptic regulation location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Activity-regulated cytoskeleton-associated proteinAliasesARC, Arg3.1, activity-regulated cytoskeleton-associated protein, activity regulated cytoskeleton associated protein, hArc1.00infobox
Activity-regulated cytoskeleton-associated proteinBand8q24.31.00infobox
Activity-regulated cytoskeleton-associated proteinBand15 D3|15 34.25 cM1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeanterior pituitary1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeright frontal lobe1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeprefrontal cortex1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeecingulate gyrus1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeanterior cingulate cortex1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeetesticle1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeedorsolateral prefrontal cortex1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeganglionic eminence1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeventricular zone1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeBrodmann area 91.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeprimary visual cortex1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeesuperior frontal gyrus1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeseminiferous tubule1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeespermatid1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeeprimary motor cortex1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeedentate gyrus of hippocampal formation granule cell1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeespermatocyte1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeehippocampus proper1.00infobox
Activity-regulated cytoskeleton-associated proteinBgeestriatum of neuraxis1.00infobox
Activity-regulated cytoskeleton-associated proteinBioGPSn/a1.00infobox
Activity-regulated cytoskeleton-associated proteinChr.Chromosome 8 (human)1.00infobox
Activity-regulated cytoskeleton-associated proteinChr.Chromosome 15 (mouse)1.00infobox
Activity-regulated cytoskeleton-associated proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Activity-regulated cytoskeleton-associated proteinEnd142,614,479 bp1.00infobox
Activity-regulated cytoskeleton-associated proteinEnd74,544,419 bp1.00infobox
Activity-regulated cytoskeleton-associated proteinEnsemblENSG000001985761.00infobox
Activity-regulated cytoskeleton-associated proteinEntrez232371.00infobox

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