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VDAC2

Voltage-dependent anion-selective channel protein 2 is a protein that in humans is encoded by the VDAC2 gene on chromosome 10. This protein is a voltage-dependent anion channel and shares high structural homology with the other VDAC isoforms. VDACs are generally involved in the regulation of cell metabolism, mitochondrial apoptosis, and spermatogenesis.…

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Aliases
VDAC2, POR, voltage dependent anion channel 2
Band
10q22.2 · 14 A3|14 11.91 cM
Bgee
mucosa of esophagus · gastrocnemius muscle · left ventricle · ganglionic eminence · right auricle of heart
BioGPS
n/a
Chr.
Chromosome 10 (human) · Chromosome 14 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Function

Clinical significance

Interactions

  • Interact Protein-protein interaction
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  • Parkin Parkin (ligase)
  • ENOS ENOS?action=edit&redlink=1

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Map overview Semantic statistics

VDAC2

Nodes39
Edges38
Triples119
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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VDAC2

Top relations

Gene ontology · 27
VDAC2 → acrosomal vesicle, anion transmembrane transport, anion transport, binding of sperm to zona pellucida, extracellular exosome, inorganic anion transport, integral component of membrane, ion transport, membrane, membrane raft, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial outer membrane, mitochondrion, myelin sheath, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of protein polymerization, nucleotide binding, nucleus, pore complex
Bgee · 20
VDAC2 → apex of heart, atrioventricular valve, endocardial cushion, epithelium of stomach, ganglionic eminence, gastrocnemius muscle, left ventricle, migratory enteric neural crest cell, mucosa of esophagus, mucous cell of stomach, muscle layer of sigmoid colon, muscle of thigh, pyloric antrum, rectum, right auricle of heart, right ventricle, seminiferous tubule, spermatid, vagina, vastus lateralis muscle
RNA expression pattern · 20
VDAC2 → apex of heart, atrioventricular valve, endocardial cushion, epithelium of stomach, ganglionic eminence, gastrocnemius muscle, left ventricle, migratory enteric neural crest cell, mucosa of esophagus, mucous cell of stomach, muscle layer of sigmoid colon, muscle of thigh, pyloric antrum, rectum, right auricle of heart, right ventricle, seminiferous tubule, spermatid, vagina, vastus lateralis muscle
related to Clinical significance · 13
VDAC2 → Although, An, Apoptosis, DNA, In, It, Programmed, ROS, The, The VDAC, The VDAC2, These, This
related to Function · 6
VDAC2 → ATP, Bcl-2, In, MPTP, VDAC, VDACs
related to Structure · 5
VDAC2 → In, N-terminal, The, VDAC, VDACs
related to External links · 3
VDAC2 → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
VDAC2 → 10q22.2, 14 A3|14 11.91 cM
Chr. · 2
VDAC2 → Chromosome 10 (human), Chromosome 14 (mouse)
End · 2
VDAC2 → 21,895,947 bp, 75,231,448 bp

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Important terminology

mitochondrial apoptosis cell protein human bp also death vdacs channel chromosome 10 membrane chr band gene apoptotic pathway vdac isoforms

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
VDAC2AliasesVDAC2, POR, voltage dependent anion channel 21.00infobox
VDAC2Band10q22.21.00infobox
VDAC2Band14 A3|14 11.91 cM1.00infobox
VDAC2Bgeemucosa of esophagus1.00infobox
VDAC2Bgeegastrocnemius muscle1.00infobox
VDAC2Bgeeleft ventricle1.00infobox
VDAC2Bgeeganglionic eminence1.00infobox
VDAC2Bgeeright auricle of heart1.00infobox
VDAC2Bgeemuscle of thigh1.00infobox
VDAC2Bgeeapex of heart1.00infobox
VDAC2Bgeemuscle layer of sigmoid colon1.00infobox
VDAC2Bgeerectum1.00infobox
VDAC2Bgeevagina1.00infobox
VDAC2Bgeeepithelium of stomach1.00infobox
VDAC2Bgeespermatid1.00infobox
VDAC2Bgeeendocardial cushion1.00infobox
VDAC2Bgeeatrioventricular valve1.00infobox
VDAC2Bgeeseminiferous tubule1.00infobox
VDAC2Bgeemucous cell of stomach1.00infobox
VDAC2Bgeepyloric antrum1.00infobox
VDAC2Bgeeright ventricle1.00infobox
VDAC2Bgeemigratory enteric neural crest cell1.00infobox
VDAC2Bgeevastus lateralis muscle1.00infobox
VDAC2BioGPSn/a1.00infobox
VDAC2Chr.Chromosome 10 (human)1.00infobox
VDAC2Chr.Chromosome 14 (mouse)1.00infobox
VDAC2DatabasesNCBI: entry; OMA: entry1.00infobox
VDAC2End75,231,448 bp1.00infobox
VDAC2End21,895,947 bp1.00infobox
VDAC2EnsemblENSG000001656371.00infobox

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