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UBQLN2: Function, Interactions & Similarity to other proteins

Ubiquilin-2 is a protein that in humans is encoded by the UBQLN2 gene.

Language: English [EN]
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UBQLN2 topic overview

The analysis highlights Function, Interactions and Similarity to other proteins as prominent areas in the source structure around UBQLN2.

Related topics
18
Source areas
5
Connected nodes
23
Extracted relationships
91
Concept neighborhoods
10
Bridge connections
23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 9 topics
Interactions · 3 topics
Clinical significance · 2 topics
Overview · 2 topics
Similarity to other proteins · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
UBQLN2, ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J8C
Band
Xp11.21 · X|X F3
Bgee
cerebellar vermis · pons · postcentral gyrus · endothelial cell · Brodmann area 23
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Similarity to other proteins

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How UBQLN2 connects Entity context

The extracted context around UBQLN2 shows recurring relationship patterns in the source. For example, UBQLN2 → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, cerebellar vermis, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, habenula, median eminence, middle temporal gyrus, paraventricular nucleus of hypothalamus, pons, postcentral gyrus, retinal pigment epithelium, seminal vesicula, subiculum, superior vestibular nucleus, ventral tegmental area, ventromedial nucleus Another extracted example is UBQLN2 → autophagosome, autophagosome assembly, autophagy, cytoplasm, cytoplasmic vesicle, cytosol, membrane, negative regulation of clathrin-dependent endocytosis, negative regulation of G protein-coupled receptor internalization, nucleus, plasma membrane, polyubiquitin modification-dependent protein binding, positive regulation of ER-associated ubiquitin-dependent protein catabolic process, protein binding, regulation of autophagosome assembly, regulation of macroautophagy, ubiquitin-dependent ERAD pathway, ubiquitin-dependent protein catabolic process. Use these groups to spot repeated connection types before inspecting the individual relationships.

UBQLN2

Top relations

Bgee · 19
UBQLN2 → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, cerebellar vermis, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, habenula, median eminence, middle temporal gyrus, paraventricular nucleus of hypothalamus, pons, postcentral gyrus, retinal pigment epithelium, seminal vesicula, subiculum, superior vestibular nucleus, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 19
UBQLN2 → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, cerebellar vermis, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, habenula, median eminence, middle temporal gyrus, paraventricular nucleus of hypothalamus, pons, postcentral gyrus, retinal pigment epithelium, seminal vesicula, subiculum, superior vestibular nucleus, ventral tegmental area, ventromedial nucleus
Gene ontology · 18
UBQLN2 → autophagosome, autophagosome assembly, autophagy, cytoplasm, cytoplasmic vesicle, cytosol, membrane, negative regulation of clathrin-dependent endocytosis, negative regulation of G protein-coupled receptor internalization, nucleus, plasma membrane, polyubiquitin modification-dependent protein binding, positive regulation of ER-associated ubiquitin-dependent protein catabolic process, protein binding, regulation of autophagosome assembly, regulation of macroautophagy, ubiquitin-dependent ERAD pathway, ubiquitin-dependent protein catabolic process
related to Clinical significance · 7
UBQLN2 → ALS, C9ORF72, In, TDP-43, The, This, Ubiquilin
related to Similarity to other proteins · 3
UBQLN2 → Human UBQLN2, UBQLN1, UBQLN4
Band · 2
UBQLN2 → Xp11.21, X|X F3
Chr. · 2
UBQLN2 → X chromosome (human), X chromosome (mouse)
End · 2
UBQLN2 → 152,284,566 bp, 56,567,868 bp
related to Interactions · 2
UBQLN2 → HERPUD1, UBE3A
Aliases · 1
UBQLN2 → UBQLN2, ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene human chr band protein ubiquilin chromosome location similarity mouse function search 567 868 end 56 284 566 proteins

UBQLN2 relationships Subject–Predicate–Object triples

TTTA extracted 91 structured relationships around UBQLN2. Examples in this analysis include UBQLN2 → Aliases → UBQLN2, ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 2 and UBQLN2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J8C. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
UBQLN2AliasesUBQLN2, ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 21.00infobox
UBQLN2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J8C1.00infobox
UBQLN2BandXp11.211.00infobox
UBQLN2BandX|X F31.00infobox
UBQLN2Bgeecerebellar vermis1.00infobox
UBQLN2Bgeepons1.00infobox
UBQLN2Bgeepostcentral gyrus1.00infobox
UBQLN2Bgeeendothelial cell1.00infobox
UBQLN2BgeeBrodmann area 231.00infobox
UBQLN2Bgeeretinal pigment epithelium1.00infobox
UBQLN2Bgeeentorhinal cortex1.00infobox
UBQLN2Bgeesuperior vestibular nucleus1.00infobox
UBQLN2Bgeeseminal vesicula1.00infobox
UBQLN2Bgeemiddle temporal gyrus1.00infobox
UBQLN2Bgeehabenula1.00infobox
UBQLN2Bgeeventral tegmental area1.00infobox
UBQLN2Bgeearcuate nucleus1.00infobox
UBQLN2Bgeemedian eminence1.00infobox
UBQLN2Bgeesubiculum1.00infobox
UBQLN2Bgeeparaventricular nucleus of hypothalamus1.00infobox
UBQLN2Bgeeanterior amygdaloid area1.00infobox
UBQLN2Bgeeventromedial nucleus1.00infobox
UBQLN2Bgeedorsomedial hypothalamic nucleus1.00infobox
UBQLN2BioGPSMore reference expression data1.00infobox
UBQLN2Chr.X chromosome (human)1.00infobox
UBQLN2Chr.X chromosome (mouse)1.00infobox
UBQLN2DatabasesNCBI: entry; OMA: entry1.00infobox
UBQLN2End56,567,868 bp1.00infobox
UBQLN2End152,284,566 bp1.00infobox
UBQLN2EnsemblENSG000001880211.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around UBQLN2 bring nearby vocabulary together. In this analysis, examples include Gene, Similarity and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • UBQLN2
    • Gene
    • Similarity
    • Human
    • Ubiquilin
    • Degree
    • Function
    • High
    • Including
    • Related
    • Search
    • Shares
    • Location
  • ubqln2
    • Gene
    • Similarity
    • Human
    • Ubiquilin
    • Degree
    • Function
    • High
    • Including
    • Related
    • Search
    • Shares
    • Location
  • protein
    • Gene
    • Ubiquilin
    • Encoded
    • Humans
    • Ubiquilin-2
    • Ubqln2
    • Degree
    • Domain
    • End
    • Function
    • High
    • Mouse
  • gene
    • Location
    • Ubqln2
    • Chromosome
    • Bp
    • Chr
    • Human
    • Ubiquilin
    • End
    • Function
    • Mouse
    • Search
    • Similarity
  • ubiquitin-like protein
    • Domain
    • Shares
    • Ubiquilins
    • Gene
    • Ubiquilin
    • Encoded
    • Humans
    • Ubiquilin-2
    • Ubqln2
    • Degree
    • End
    • Function
  • function
    • Search
    • Location
    • Similarity
    • Chromosome
    • Clinical
    • Interactions
    • Reading
    • References
    • Significance
    • Bp
    • Chr
    • Gene
  • similarity to other proteins
    • Degree
    • High
    • Related
    • Search
    • Shares
    • Human
    • Interactions
    • Location
    • Reading
    • References
    • Significance
    • Ubqln2
  • clinical significance
    • Interactions
    • Reading
    • References
    • Significance
    • Function
    • Proteins
    • Search
    • Location
    • Similarity
    • Chromosome
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For UBQLN2, one of the stronger structural bridges in this analysis connects UBQLN2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
UBQLN2Function · splits 14 ⟂ 10
UBQLN2Interactions · splits 20 ⟂ 4
UBQLN2Overview · splits 21 ⟂ 3
UBQLN2Similarity to other proteins · splits 21 ⟂ 3
UBQLN2Clinical significance · splits 21 ⟂ 3

Map overview Semantic statistics

UBQLN2

Nodes24
Edges23
Triples91
Avg. degree1.92
Density0.083333
Components1

Source & methodology

TTTA analyzes the structure around UBQLN2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Similarity to other proteins, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — UBQLN2 · EN edition · Analysis: TopicsToTalkAbout

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