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Tissue transglutaminase: Clinical significance, Function & Structure

Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family). Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an…

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Tissue transglutaminase topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around Tissue transglutaminase.

Related topics
92
Source areas
8
Connected nodes
100
Extracted relationships
101
Related term clusters
20
Bridge connections
100

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 28 topics
Overview · 19 topics
Function · 12 topics
Structure · 11 topics
Regulation · 8 topics
Erp57 · 6 topics
Mechanism · 5 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.13
↗
3.5.1.44
↗
Aliases
TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S
Band
20q11.23 · 2 H1|2 78.72 cM
Bgee
beta cell · right coronary artery · left coronary artery · canal of the cervix · popliteal artery

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Mechanism

Regulation

Function

Clinical significance

Interactions

Erp57

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Tissue transglutaminase connects Entity context

The extracted context around Tissue transglutaminase shows recurring relationship patterns in the source. For example, Tissue transglutaminase → acyltransferase activity, apoptotic cell clearance, blood vessel remodeling, branching involved in salivary gland morphogenesis, collagen-containing extracellular matrix, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, extracellular matrix, focal adhesion, GTP binding, intrinsic component of plasma membrane, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, metal ion binding, mitochondrion, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, plasma membrane Another extracted example is Tissue transglutaminase → ascending aorta, beta cell, canal of the cervix, carotid body, ciliary body, conjunctival fornix, decidua, efferent ductule, external carotid artery, left coronary artery, mesenteric lymph nodes, Paneth cell, popliteal artery, right auricle of heart, right coronary artery, right lung lobe, right uterine tube, tibial arteries, tunica media of zone of aorta, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tissue transglutaminase

Top relations

Gene ontology · 33
Tissue transglutaminase → acyltransferase activity, apoptotic cell clearance, blood vessel remodeling, branching involved in salivary gland morphogenesis, collagen-containing extracellular matrix, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, extracellular matrix, focal adhesion, GTP binding, intrinsic component of plasma membrane, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, metal ion binding, mitochondrion, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, plasma membrane
Bgee · 20
Tissue transglutaminase → ascending aorta, beta cell, canal of the cervix, carotid body, ciliary body, conjunctival fornix, decidua, efferent ductule, external carotid artery, left coronary artery, mesenteric lymph nodes, Paneth cell, popliteal artery, right auricle of heart, right coronary artery, right lung lobe, right uterine tube, tibial arteries, tunica media of zone of aorta, upper lobe of left lung
RNA expression pattern · 20
Tissue transglutaminase → ascending aorta, beta cell, canal of the cervix, carotid body, ciliary body, conjunctival fornix, decidua, efferent ductule, external carotid artery, left coronary artery, mesenteric lymph nodes, Paneth cell, popliteal artery, right auricle of heart, right coronary artery, right lung lobe, right uterine tube, tibial arteries, tunica media of zone of aorta, upper lobe of left lung
Band · 2
Tissue transglutaminase → 2 H1|2 78.72 cM, 20q11.23
Chr. · 2
Tissue transglutaminase → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
Tissue transglutaminase → 157,988,356 bp, 38,166,578 bp
2.3.2.13 · 1
Tissue transglutaminase → ↗
3.5.1.44 · 1
Tissue transglutaminase → ↗
Aliases · 1
Tissue transglutaminase → TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG
Available structures · 1
Tissue transglutaminase → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ttg activity tg2 extracellular protein also enzyme disulfide disease proteins transglutaminase including calcium cell human gtp bond crosslinking diseases binding

Tissue transglutaminase relationships Subject–Predicate–Object triples

TTTA extracted 101 structured relationships around Tissue transglutaminase. Examples in this analysis include Tissue transglutaminase → 2.3.2.13 → ↗ and Tissue transglutaminase → Aliases → TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tissue transglutaminase2.3.2.13↗1.00infobox
Tissue transglutaminase3.5.1.44↗1.00infobox
Tissue transglutaminaseAliasesTGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG1.00infobox
Tissue transglutaminaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S1.00infobox
Tissue transglutaminaseBand20q11.231.00infobox
Tissue transglutaminaseBand2 H1|2 78.72 cM1.00infobox
Tissue transglutaminaseBgeebeta cell1.00infobox
Tissue transglutaminaseBgeeright coronary artery1.00infobox
Tissue transglutaminaseBgeeleft coronary artery1.00infobox
Tissue transglutaminaseBgeecanal of the cervix1.00infobox
Tissue transglutaminaseBgeepopliteal artery1.00infobox
Tissue transglutaminaseBgeetibial arteries1.00infobox
Tissue transglutaminaseBgeeright auricle of heart1.00infobox
Tissue transglutaminaseBgeeright uterine tube1.00infobox
Tissue transglutaminaseBgeeupper lobe of left lung1.00infobox
Tissue transglutaminaseBgeedecidua1.00infobox
Tissue transglutaminaseBgeeconjunctival fornix1.00infobox
Tissue transglutaminaseBgeePaneth cell1.00infobox
Tissue transglutaminaseBgeetunica media of zone of aorta1.00infobox
Tissue transglutaminaseBgeeascending aorta1.00infobox
Tissue transglutaminaseBgeeright lung lobe1.00infobox
Tissue transglutaminaseBgeeciliary body1.00infobox
Tissue transglutaminaseBgeemesenteric lymph nodes1.00infobox
Tissue transglutaminaseBgeeefferent ductule1.00infobox
Tissue transglutaminaseBgeecarotid body1.00infobox
Tissue transglutaminaseBgeeexternal carotid artery1.00infobox
Tissue transglutaminaseBioGPSMore reference expression data1.00infobox
Tissue transglutaminaseChr.Chromosome 20 (human)1.00infobox
Tissue transglutaminaseChr.Chromosome 2 (mouse)1.00infobox
Tissue transglutaminaseDatabasesNCBI: entry; OMA: entry1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Tissue transglutaminase bring nearby vocabulary together. In this analysis, examples include Tg2, Enzyme and Many. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tissue transglutaminase
    • Tg2
    • Enzyme
    • Many
    • Intracellular
    • Regulation
    • Response
    • Protein
    • Binding
    • Diseases
    • Including
    • Disulfide
    • Ttg
  • tissue transglutaminase
    • Tg2
    • Enzyme
    • Many
    • Intracellular
    • Regulation
    • Response
    • Protein
    • Binding
    • Diseases
    • Including
    • Disulfide
    • Ttg
  • enzyme
    • Bond
    • Transglutaminase
    • Tg2
    • Disulfide
    • Regulation
    • Celiac
    • Diseases
    • Crosslinking
    • Disease
    • Protein
    • Chromosome
    • Gene
  • transglutaminase
    • Tg2
    • Enzyme
    • Many
    • Intracellular
    • Regulation
    • Response
    • Protein
    • Binding
    • Diseases
    • Including
    • Disulfide
    • Ttg
  • celiac disease
    • Disease
    • Gluten
    • Small
    • Response
    • Ttg
    • Enzyme
    • Activity
    • Extracellular
    • Chromosome
    • Gene
    • Bp
    • Chr
  • extracellular matrix
    • Small
    • Cellular
    • Protein
    • Ttg
    • Tg2
    • Cell
    • Disulfide
    • Many
    • Found
    • Intracellular
    • Regulation
    • Response
  • cell adhesion
    • Types
    • Gtp
    • Including
    • Gene
    • Ttg
    • Activity
    • Many
    • Cellular
    • Extracellular
    • Regulation
    • Response
    • Calcium
  • calcium
    • Gtp
    • Cell
    • Ttg
    • Extracellular
    • Chromosome
    • Gene
    • Chr
    • Different
    • Interactions
    • Peptide
    • Cellular
    • Glutamine

Connections between topic areas Semantic bridges

For Tissue transglutaminase, one of the stronger structural bridges in this analysis connects Tissue transglutaminase with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tissue transglutaminase — Clinical significance · splits 72 ⟂ 29
Tissue transglutaminase — Overview · splits 81 ⟂ 20
Tissue transglutaminase — Function · splits 88 ⟂ 13
Tissue transglutaminase — Structure · splits 89 ⟂ 12
Tissue transglutaminase — Regulation · splits 92 ⟂ 9
Tissue transglutaminase — Erp57 · splits 94 ⟂ 7
Tissue transglutaminase — Mechanism · splits 95 ⟂ 6
Tissue transglutaminase — Interactions · splits 97 ⟂ 4

Map overview Semantic statistics

Tissue transglutaminase

Nodes101
Edges100
Triples101
Avg. degree1.98
Density0.019802
Components1

Source & methodology

TTTA analyzes the structure around Tissue transglutaminase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tissue transglutaminase · EN edition · Analysis: TopicsToTalkAbout

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