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Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family). Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an…
The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around Tissue transglutaminase.
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The extracted context around Tissue transglutaminase shows recurring relationship patterns in the source. For example, Tissue transglutaminase → acyltransferase activity, apoptotic cell clearance, blood vessel remodeling, branching involved in salivary gland morphogenesis, collagen-containing extracellular matrix, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, extracellular matrix, focal adhesion, GTP binding, intrinsic component of plasma membrane, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, metal ion binding, mitochondrion, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, plasma membrane Another extracted example is Tissue transglutaminase → ascending aorta, beta cell, canal of the cervix, carotid body, ciliary body, conjunctival fornix, decidua, efferent ductule, external carotid artery, left coronary artery, mesenteric lymph nodes, Paneth cell, popliteal artery, right auricle of heart, right coronary artery, right lung lobe, right uterine tube, tibial arteries, tunica media of zone of aorta, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.
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ttg activity tg2 extracellular protein also enzyme disulfide disease proteins transglutaminase including calcium cell human gtp bond crosslinking diseases binding
TTTA extracted 101 structured relationships around Tissue transglutaminase. Examples in this analysis include Tissue transglutaminase → 2.3.2.13 → ↗ and Tissue transglutaminase → Aliases → TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Tissue transglutaminase | 2.3.2.13 | ↗ | 1.00 | infobox |
| Tissue transglutaminase | 3.5.1.44 | ↗ | 1.00 | infobox |
| Tissue transglutaminase | Aliases | TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG | 1.00 | infobox |
| Tissue transglutaminase | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S | 1.00 | infobox |
| Tissue transglutaminase | Band | 20q11.23 | 1.00 | infobox |
| Tissue transglutaminase | Band | 2 H1|2 78.72 cM | 1.00 | infobox |
| Tissue transglutaminase | Bgee | beta cell | 1.00 | infobox |
| Tissue transglutaminase | Bgee | right coronary artery | 1.00 | infobox |
| Tissue transglutaminase | Bgee | left coronary artery | 1.00 | infobox |
| Tissue transglutaminase | Bgee | canal of the cervix | 1.00 | infobox |
| Tissue transglutaminase | Bgee | popliteal artery | 1.00 | infobox |
| Tissue transglutaminase | Bgee | tibial arteries | 1.00 | infobox |
| Tissue transglutaminase | Bgee | right auricle of heart | 1.00 | infobox |
| Tissue transglutaminase | Bgee | right uterine tube | 1.00 | infobox |
| Tissue transglutaminase | Bgee | upper lobe of left lung | 1.00 | infobox |
| Tissue transglutaminase | Bgee | decidua | 1.00 | infobox |
| Tissue transglutaminase | Bgee | conjunctival fornix | 1.00 | infobox |
| Tissue transglutaminase | Bgee | Paneth cell | 1.00 | infobox |
| Tissue transglutaminase | Bgee | tunica media of zone of aorta | 1.00 | infobox |
| Tissue transglutaminase | Bgee | ascending aorta | 1.00 | infobox |
| Tissue transglutaminase | Bgee | right lung lobe | 1.00 | infobox |
| Tissue transglutaminase | Bgee | ciliary body | 1.00 | infobox |
| Tissue transglutaminase | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| Tissue transglutaminase | Bgee | efferent ductule | 1.00 | infobox |
| Tissue transglutaminase | Bgee | carotid body | 1.00 | infobox |
| Tissue transglutaminase | Bgee | external carotid artery | 1.00 | infobox |
| Tissue transglutaminase | BioGPS | More reference expression data | 1.00 | infobox |
| Tissue transglutaminase | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| Tissue transglutaminase | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Tissue transglutaminase | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
The concept neighborhoods around Tissue transglutaminase bring nearby vocabulary together. In this analysis, examples include Tg2, Enzyme and Many. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Tissue transglutaminase, one of the stronger structural bridges in this analysis connects Tissue transglutaminase with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Tissue transglutaminase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Tissue transglutaminase · EN edition · Analysis: TopicsToTalkAbout