SORBS2

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Explore the main themes, entities and connections around SORBS2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Cbl C-Abl Pyk2 Skeletal muscle T-tubules

14 related topics

Interactions

Interact ABL ABL2 ACTC1 CBL

7 related topics

Structure

SH3 domains CAP/ponsin Vinexin C-terminal N-terminal

6 related topics

Clinical Significance

Myocardial Myocardial infarction Pericentric inversion

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ
Band: 4q35.1 · 8|8 B1.1
Bgee: right ventricle · popliteal artery · tibial arteries · myocardium of left ventricle · right coronary artery
BioGPS: More reference expression data
Chr.: Chromosome 4 (human) · Chromosome 8 (mouse)

Topics to explore

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Overview

Structure

SH3 domains SH3 domain
CAP/ponsin SORBS1
Vinexin SORBS3
C-terminal C-terminus
N-terminal N-terminus
Flotillin FLOT1

Function

Cbl Cbl gene
C-Abl ABL1
Pyk2
Skeletal muscle
T-tubules T-tubule
Sarcoplasmic reticular Sarcoplasmic reticulum
Cardiac
Alpha actinin-2 Actinin, alpha 2
Vinculin
Spectrin SPEC
Paxillin
Myofibril
Hypertrophic Cardiac hypertrophy
PDLIM5

Clinical Significance

Myocardial Myocardium
Myocardial infarction
Pericentric inversion Chromosomal inversion

Interactions

Interact Protein-protein interaction
ABL ABL (gene)
ABL2
ACTC1
CBL CBL (gene)
PTK2B
PLDN

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes43

Edges42

Triples89

Avg. degree1.95

Density0.046512

Components1

How this topic connects Entity context

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SORBS2

Top relations

Gene ontology · 23

SORBS2 → actin cytoskeleton, actin filament organization, apical plasma membrane, biological process, cell growth involved in cardiac muscle cell development, cell junction, cell projection, cytoplasm, cytoskeletal anchor activity, focal adhesion, lamellipodium, membrane, Notch signaling pathway, nucleic acid binding, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, protein binding, RNA binding

Bgee · 20

SORBS2 → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, decidua, gastrula, left adrenal cortex, left ventricle, myocardium of left ventricle, myocardium of ventricle, otolith organ, parotid gland, piriform cortex, popliteal artery, retinal pigment epithelium, right adrenal cortex, right coronary artery, right ventricle, tibial arteries, utricle

RNA expression pattern · 20

related to Clinical Significance · 3

SORBS2 → ArgBP2, Chromosome, Elevated

Band · 2

SORBS2 → 4q35.1, 8|8 B1.1

Chr. · 2

SORBS2 → Chromosome 4 (human), Chromosome 8 (mouse)

End · 2

SORBS2 → 185,956,652 bp, 46,280,943 bp

Aliases · 1

SORBS2 → SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2

Available structures · 1

SORBS2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ

BioGPS · 1

SORBS2 → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

argbp2 cardiac bp sorbin chr human band chromosome gene sh3 muscle cells signaling abl flotillin family soho domains protein actin

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
SORBS2	Aliases	SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2	1.00	infobox
SORBS2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ	1.00	infobox
SORBS2	Band	4q35.1	1.00	infobox
SORBS2	Band	8\|8 B1.1	1.00	infobox
SORBS2	Bgee	right ventricle	1.00	infobox
SORBS2	Bgee	popliteal artery	1.00	infobox
SORBS2	Bgee	tibial arteries	1.00	infobox
SORBS2	Bgee	myocardium of left ventricle	1.00	infobox
SORBS2	Bgee	right coronary artery	1.00	infobox
SORBS2	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
SORBS2	Bgee	retinal pigment epithelium	1.00	infobox
SORBS2	Bgee	right adrenal cortex	1.00	infobox
SORBS2	Bgee	left adrenal cortex	1.00	infobox
SORBS2	Bgee	apex of heart	1.00	infobox
SORBS2	Bgee	otolith organ	1.00	infobox
SORBS2	Bgee	utricle	1.00	infobox
SORBS2	Bgee	gastrula	1.00	infobox
SORBS2	Bgee	myocardium of ventricle	1.00	infobox
SORBS2	Bgee	atrioventricular valve	1.00	infobox
SORBS2	Bgee	decidua	1.00	infobox
SORBS2	Bgee	atrium	1.00	infobox
SORBS2	Bgee	parotid gland	1.00	infobox
SORBS2	Bgee	piriform cortex	1.00	infobox
SORBS2	Bgee	left ventricle	1.00	infobox
SORBS2	BioGPS	More reference expression data	1.00	infobox
SORBS2	Chr.	Chromosome 4 (human)	1.00	infobox
SORBS2	Chr.	Chromosome 8 (mouse)	1.00	infobox
SORBS2	Databases	NCBI: entry; OMA: entry	1.00	infobox
SORBS2	End	185,956,652 bp	1.00	infobox
SORBS2	End	46,280,943 bp	1.00	infobox

Related concept clusters Concept neighborhoods

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Connections between topic areas Semantic bridges

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