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SORBS2: Function, Interactions & Structure

ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene. ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains. ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at…

Language: English [EN]
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SORBS2 topic overview

The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around SORBS2.

Related topics
37
Source areas
5
Connected nodes
42
Extracted relationships
89
Concept neighborhoods
14
Bridge connections
42

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics
Interactions · 7 topics
Overview · 7 topics
Structure · 6 topics
Clinical Significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ
Band
4q35.1 · 8|8 B1.1
Bgee
right ventricle · popliteal artery · tibial arteries · myocardium of left ventricle · right coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 8 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical Significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SORBS2 connects Entity context

The extracted context around SORBS2 shows recurring relationship patterns in the source. For example, SORBS2 → actin cytoskeleton, actin filament organization, apical plasma membrane, biological process, cell growth involved in cardiac muscle cell development, cell junction, cell projection, cytoplasm, cytoskeletal anchor activity, focal adhesion, lamellipodium, membrane, Notch signaling pathway, nucleic acid binding, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, protein binding, RNA binding Another extracted example is SORBS2 → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, decidua, gastrula, left adrenal cortex, left ventricle, myocardium of left ventricle, myocardium of ventricle, otolith organ, parotid gland, piriform cortex, popliteal artery, retinal pigment epithelium, right adrenal cortex, right coronary artery, right ventricle, tibial arteries, utricle. Use these groups to spot repeated connection types before inspecting the individual relationships.

SORBS2

Top relations

Gene ontology · 23
SORBS2 → actin cytoskeleton, actin filament organization, apical plasma membrane, biological process, cell growth involved in cardiac muscle cell development, cell junction, cell projection, cytoplasm, cytoskeletal anchor activity, focal adhesion, lamellipodium, membrane, Notch signaling pathway, nucleic acid binding, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, protein binding, RNA binding
Bgee · 20
SORBS2 → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, decidua, gastrula, left adrenal cortex, left ventricle, myocardium of left ventricle, myocardium of ventricle, otolith organ, parotid gland, piriform cortex, popliteal artery, retinal pigment epithelium, right adrenal cortex, right coronary artery, right ventricle, tibial arteries, utricle
RNA expression pattern · 20
SORBS2 → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, decidua, gastrula, left adrenal cortex, left ventricle, myocardium of left ventricle, myocardium of ventricle, otolith organ, parotid gland, piriform cortex, popliteal artery, retinal pigment epithelium, right adrenal cortex, right coronary artery, right ventricle, tibial arteries, utricle
related to Clinical Significance · 3
SORBS2 → ArgBP2, Chromosome, Elevated
Band · 2
SORBS2 → 4q35.1, 8|8 B1.1
Chr. · 2
SORBS2 → Chromosome 4 (human), Chromosome 8 (mouse)
End · 2
SORBS2 → 185,956,652 bp, 46,280,943 bp
Aliases · 1
SORBS2 → SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2
Available structures · 1
SORBS2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ
BioGPS · 1
SORBS2 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

argbp2 cardiac bp sorbin chr human band chromosome gene sh3 muscle cells signaling abl flotillin family soho domains protein actin

SORBS2 relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around SORBS2. Examples in this analysis include SORBS2 → Aliases → SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2 and SORBS2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SORBS2AliasesSORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 21.00infobox
SORBS2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4IGZ1.00infobox
SORBS2Band4q35.11.00infobox
SORBS2Band8|8 B1.11.00infobox
SORBS2Bgeeright ventricle1.00infobox
SORBS2Bgeepopliteal artery1.00infobox
SORBS2Bgeetibial arteries1.00infobox
SORBS2Bgeemyocardium of left ventricle1.00infobox
SORBS2Bgeeright coronary artery1.00infobox
SORBS2Bgeecardiac muscle tissue of right atrium1.00infobox
SORBS2Bgeeretinal pigment epithelium1.00infobox
SORBS2Bgeeright adrenal cortex1.00infobox
SORBS2Bgeeleft adrenal cortex1.00infobox
SORBS2Bgeeapex of heart1.00infobox
SORBS2Bgeeotolith organ1.00infobox
SORBS2Bgeeutricle1.00infobox
SORBS2Bgeegastrula1.00infobox
SORBS2Bgeemyocardium of ventricle1.00infobox
SORBS2Bgeeatrioventricular valve1.00infobox
SORBS2Bgeedecidua1.00infobox
SORBS2Bgeeatrium1.00infobox
SORBS2Bgeeparotid gland1.00infobox
SORBS2Bgeepiriform cortex1.00infobox
SORBS2Bgeeleft ventricle1.00infobox
SORBS2BioGPSMore reference expression data1.00infobox
SORBS2Chr.Chromosome 4 (human)1.00infobox
SORBS2Chr.Chromosome 8 (mouse)1.00infobox
SORBS2DatabasesNCBI: entry; OMA: entry1.00infobox
SORBS2End185,956,652 bp1.00infobox
SORBS2End46,280,943 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SORBS2 bring nearby vocabulary together. In this analysis, examples include Search, Location and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Actin
    • Gene
    • Sorbs2
    • Muscle
    • Signaling
    • Cardiac
    • Expressed
    • Fibers
    • Function
    • Mouse
    • Nucleus
    • Search
  • cardiac muscle
    • Muscle
    • May
    • Cells
    • Signaling
    • Expressed
    • Fibers
    • Nucleus
    • Stress
    • Flotillin
    • Protein
    • Sorbs2
    • Chromosome
  • actin
    • Expressed
    • Fibers
    • Nucleus
    • Stress
    • Muscle
    • Protein
    • Cardiac
    • Cells
    • Signaling
    • Function
    • Mouse
    • Search
  • cardiac
    • Muscle
    • May
    • Cells
    • Signaling
    • Expressed
    • Fibers
    • Nucleus
    • Stress
    • Flotillin
    • Protein
    • Sorbs2
    • Chromosome
  • gene
    • Location
    • Human
    • Sorbs2
    • Bp
    • Chr
    • Chromosome
    • Function
    • Mouse
    • Search
    • Protein
    • Band
    • Sh3
  • sh3 domains
    • Homology
    • Sorbin
    • Soho
    • Domains
    • Proteins
    • Sh3
    • Small
    • Domain
    • Family
    • Sorbs2
    • Adaptor
    • Belongs
  • skeletal muscle
    • May
    • Signaling
    • Expressed
    • Fibers
    • Nucleus
    • Stress
    • Flotillin
    • Protein
    • Function
    • Mouse
    • Search
    • Structures
  • function
    • Search
    • Location
    • Gene
    • Human
    • Sorbs2
    • Bp
    • Chr
    • Chromosome
    • Mouse
    • Nucleus
    • Structures
    • Cytoskeletal

Connections between topic areas Semantic bridges

For SORBS2, one of the stronger structural bridges in this analysis connects SORBS2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SORBS2Function · splits 28 ⟂ 15
SORBS2Overview · splits 35 ⟂ 8
SORBS2Interactions · splits 35 ⟂ 8
SORBS2Structure · splits 36 ⟂ 7
SORBS2Clinical Significance · splits 39 ⟂ 4

Map overview Semantic statistics

SORBS2

Nodes43
Edges42
Triples89
Avg. degree1.95
Density0.046512
Components1

Source & methodology

TTTA analyzes the structure around SORBS2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SORBS2 · EN edition · Analysis: TopicsToTalkAbout

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