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Cyclooxygenase-2

Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene. In humans it is one of three cyclooxygenases. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, which is expressed in inflammation.

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1.14.99.1
↗
Aliases
PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
Band
1q31.1 · 1 G1|1 63.84 cM
Bgee
seminal vesicula · cartilage tissue · mucosa of urinary bladder · beta cell · periodontal fiber
BioGPS
More reference expression data

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Cyclooxygenase-2

Nodes109
Edges108
Triples173
Avg. degree1.98
Density0.018349
Components1

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Cyclooxygenase-2

Top relations

Gene ontology · 101
Cyclooxygenase-2 → ageing, angiogenesis, arachidonate 15-lipoxygenase activity, bone mineralization, brown fat cell differentiation, caveola, cellular oxidant detoxification, cellular response to ATP, cellular response to fluid shear stress, cellular response to heat, cellular response to hypoxia, cellular response to lead ion, cellular response to mechanical stimulus, cellular response to non-ionic osmotic stress, cellular response to UV, cyclooxygenase pathway, cytokine-mediated signaling pathway, cytoplasm, decidualization, dioxygenase activity
Bgee · 20
Cyclooxygenase-2 → beta cell, calvaria, cartilage tissue, cumulus cell, decidua, dentate gyrus, endothelial cell of lymphatic vessel, gallbladder, gastrula, granulocyte, mucosa of paranasal sinus, mucosa of urinary bladder, periodontal fiber, right lung lobe, saphenous vein, seminal vesicula, stroma of bone marrow, subdivision of hippocampus, vena cava, visceral pleura
RNA expression pattern · 20
Cyclooxygenase-2 → beta cell, calvaria, cartilage tissue, cumulus cell, decidua, dentate gyrus, endothelial cell of lymphatic vessel, gallbladder, gastrula, granulocyte, mucosa of paranasal sinus, mucosa of urinary bladder, periodontal fiber, right lung lobe, saphenous vein, seminal vesicula, stroma of bone marrow, subdivision of hippocampus, vena cava, visceral pleura
Band · 2
Cyclooxygenase-2 → 1 G1|1 63.84 cM, 1q31.1
Chr. · 2
Cyclooxygenase-2 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
Cyclooxygenase-2 → 149,983,978 bp, 186,680,922 bp
1.14.99.1 · 1
Cyclooxygenase-2 → ↗
Aliases · 1
Cyclooxygenase-2 → PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2
Available structures · 1
Cyclooxygenase-2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
BioGPS · 1
Cyclooxygenase-2 → More reference expression data

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Important terminology

ptgs2 cox-2 acid human prostaglandins prostaglandin arachidonic gene expression inhibitors bp inflammation ptgs cox cells peroxidase pgg2 radical also two

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cyclooxygenase-21.14.99.1↗1.00infobox
Cyclooxygenase-2AliasesPTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 21.00infobox
Cyclooxygenase-2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR1.00infobox
Cyclooxygenase-2Band1q31.11.00infobox
Cyclooxygenase-2Band1 G1|1 63.84 cM1.00infobox
Cyclooxygenase-2Bgeeseminal vesicula1.00infobox
Cyclooxygenase-2Bgeecartilage tissue1.00infobox
Cyclooxygenase-2Bgeemucosa of urinary bladder1.00infobox
Cyclooxygenase-2Bgeebeta cell1.00infobox
Cyclooxygenase-2Bgeeperiodontal fiber1.00infobox
Cyclooxygenase-2Bgeevena cava1.00infobox
Cyclooxygenase-2Bgeevisceral pleura1.00infobox
Cyclooxygenase-2Bgeesaphenous vein1.00infobox
Cyclooxygenase-2Bgeemucosa of paranasal sinus1.00infobox
Cyclooxygenase-2Bgeegallbladder1.00infobox
Cyclooxygenase-2Bgeegranulocyte1.00infobox
Cyclooxygenase-2Bgeedecidua1.00infobox
Cyclooxygenase-2Bgeegastrula1.00infobox
Cyclooxygenase-2Bgeestroma of bone marrow1.00infobox
Cyclooxygenase-2Bgeedentate gyrus1.00infobox
Cyclooxygenase-2Bgeecumulus cell1.00infobox
Cyclooxygenase-2Bgeeendothelial cell of lymphatic vessel1.00infobox
Cyclooxygenase-2Bgeeright lung lobe1.00infobox
Cyclooxygenase-2Bgeecalvaria1.00infobox
Cyclooxygenase-2Bgeesubdivision of hippocampus1.00infobox
Cyclooxygenase-2BioGPSMore reference expression data1.00infobox
Cyclooxygenase-2Chr.Chromosome 1 (human)1.00infobox
Cyclooxygenase-2Chr.Chromosome 1 (mouse)1.00infobox
Cyclooxygenase-2DatabasesNCBI: entry; OMA: entry1.00infobox
Cyclooxygenase-2End186,680,922 bp1.00infobox

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