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Prostacyclin: History & Applications

Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator.

Language: English [EN]
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Prostacyclin topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Prostacyclin.

Related topics
55
Source areas
8
Connected nodes
63
Extracted relationships
75
Concept neighborhoods
25
Bridge connections
63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 13 topics
Mechanism · 10 topics
Synthesis · 10 topics
Function · 8 topics
History · 5 topics
Overview · 4 topics
Medical uses · 3 topics
Degradation · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B01AC09 (WHO)
CAS Number
35121-78-9 Y
ChEMBL
ChEMBL1139 N
ChemSpider
102770 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Medical uses

Degradation

Mechanism

Pharmacology

Synthesis

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Prostacyclin connects Entity context

The extracted context around Prostacyclin shows recurring relationship patterns in the source. For example, Prostacyclin → During, PG-X, Professor John Vane, Royal College, Salvador Moncada, Surgeons, The Wellcome Foundation, They, This, Thromboxane A2, UK, Vane, Working Another extracted example is Prostacyclin → Although, COX, COX-2, EPA, H2, I2, PGH2, PGH3, PGI2, PGI3, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Prostacyclin

Top relations

related to history · 13
Prostacyclin → During, PG-X, Professor John Vane, Royal College, Salvador Moncada, Surgeons, The Wellcome Foundation, They, This, Thromboxane A2, UK, Vane, Working
related to Biosynthesis · 12
Prostacyclin → Although, COX, COX-2, EPA, H2, I2, PGH2, PGH3, PGI2, PGI3, The, This
related to Mechanism · 9
Prostacyclin → A2, As, Gs, It, PGI2, PKA, The, This, TXA2
related to Medical uses · 6
Prostacyclin → III, In, It, IV PAH, PAH, Prostacyclins
related to Function · 5
Prostacyclin → Both, It, Prostacyclin's, These, TXA2
related to Artificial synthesis · 3
Prostacyclin → After, Because, F2α
related to Degradation · 3
Prostacyclin → Even, F1α, PGF1
related to Pharmacology · 3
Prostacyclin → PPH, Raynaud's, Synthetic
KEGG · 2
Prostacyclin → as salt: D01337, D00106
Legal status · 2
Prostacyclin → AU: S4 (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

platelet pgi2 also epoprostenol used thromboxane prostaglandin drug endothelial prostaglandins eicosanoid vasodilator activation cells camp txa2 team synthesis acid derived

Prostacyclin relationships Subject–Predicate–Object triples

TTTA extracted 75 structured relationships around Prostacyclin. Examples in this analysis include Prostacyclin → 3D model (JSmol) → Interactive image and Prostacyclin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Prostacyclin3D model (JSmol)Interactive image1.00infobox
ProstacyclinAHFS/Drugs.comMonograph1.00infobox
ProstacyclinATC codeB01AC09 (WHO)1.00infobox
ProstacyclinCAS Number35121-78-9 Y1.00infobox
ProstacyclinChEMBLChEMBL1139 N1.00infobox
ProstacyclinChemSpider102770 N1.00infobox
ProstacyclinCompTox Dashboard (EPA)DTXSID50229881.00infobox
ProstacyclinDrugBankDB01240 N1.00infobox
ProstacyclinElimination half-life42 seconds1.00infobox
ProstacyclinFormulaC20H32O51.00infobox
ProstacyclinIUPHAR/BPS19151.00infobox
ProstacyclinKEGGD001061.00infobox
ProstacyclinKEGGas salt: D013371.00infobox
ProstacyclinLegal statusAU: S4 (Prescription only)1.00infobox
ProstacyclinLegal statusUS: ℞-only1.00infobox
ProstacyclinLicense dataUS DailyMed: Epoprostenol_sodium1.00infobox
ProstacyclinMolar mass352.471 g·mol−11.00infobox
ProstacyclinPregnancy categoryAU: B11.00infobox
ProstacyclinPubChem CID52824111.00infobox
ProstacyclinTrade namesFlolan, others1.00infobox
ProstacyclinUNIIDCR9Z582X01.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Prostacyclin bring nearby vocabulary together. In this analysis, examples include Prostaglandin, Endothelial and Pgi2. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Prostacyclin
    • Prostaglandin
    • Endothelial
    • Pgi2
    • Cells
    • Thromboxane
    • Used
    • Platelet
    • Levels
    • Acid
    • Eicosanoid
    • Synthesis
    • Vasodilator
  • prostacyclin
    • Prostaglandin
    • Endothelial
    • Pgi2
    • Cells
    • Thromboxane
    • Used
    • Platelet
    • Levels
    • Acid
    • Eicosanoid
    • Synthesis
    • Vasodilator
  • prostacyclin receptors
    • Prostaglandin
    • Endothelial
    • Pgi2
    • Cells
    • Thromboxane
    • Used
    • Platelet
    • Levels
    • Acid
    • Eicosanoid
    • Synthesis
    • Vasodilator
  • prostacyclin synthase
    • Prostaglandin
    • Endothelial
    • Pgi2
    • Cells
    • Thromboxane
    • Used
    • Platelet
    • Levels
    • Acid
    • Eicosanoid
    • Synthesis
    • Vasodilator
  • platelet plug
    • Aggregation
    • Thromboxane
    • Effect
    • Levels
    • Acid
    • Epoprostenol
    • Prostacyclin
    • Arachidonic
    • Camp
    • Enzymes
    • Nsaids
    • Work
  • platelet
    • Aggregation
    • Thromboxane
    • Effect
    • Levels
    • Acid
    • Epoprostenol
    • Prostacyclin
    • Arachidonic
    • Camp
    • Enzymes
    • Nsaids
    • Work
  • eicosanoid
    • Thromboxane
    • Prostaglandin
    • Lipid
    • Molecules
    • Aggregation
    • Effect
    • Enzymes
    • Nsaids
    • Cox
    • Pgi2
    • Prostaglandins
    • Txa2
  • nsaids
    • Enzymes
    • Aggregation
    • Effect
    • Pulmonary
    • Cox
    • Vasodilator
    • Thromboxane
    • Used
    • Platelet
    • Pgi2
    • Prostacyclin

Connections between topic areas Semantic bridges

For Prostacyclin, one of the stronger structural bridges in this analysis connects Prostacyclin with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ProstacyclinPharmacology · splits 50 ⟂ 14
ProstacyclinMechanism · splits 53 ⟂ 11
ProstacyclinSynthesis · splits 53 ⟂ 11
ProstacyclinFunction · splits 55 ⟂ 9
ProstacyclinHistory · splits 58 ⟂ 6
ProstacyclinOverview · splits 59 ⟂ 5
ProstacyclinMedical uses · splits 60 ⟂ 4
ProstacyclinDegradation · splits 61 ⟂ 3

Map overview Semantic statistics

Prostacyclin

Nodes64
Edges63
Triples75
Avg. degree1.97
Density0.03125
Components1

Source & methodology

TTTA analyzes the structure around Prostacyclin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Prostacyclin · EN edition · Analysis: TopicsToTalkAbout

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