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Prostacyclin

Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator.

History & Applications

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B01AC09 (WHO)
CAS Number
35121-78-9 Y
ChEMBL
ChEMBL1139 N
ChemSpider
102770 N

Topics to explore

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Overview

Function

Medical uses

Degradation

Mechanism

Pharmacology

Synthesis

History

Advanced semantic analysis

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Map overview Semantic statistics

Prostacyclin

Nodes64
Edges63
Triples75
Avg. degree1.97
Density0.03125
Components1

How this topic connects Entity context

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Prostacyclin

Top relations

related to history · 13
Prostacyclin → During, PG-X, Professor John Vane, Royal College, Salvador Moncada, Surgeons, The Wellcome Foundation, They, This, Thromboxane A2, UK, Vane, Working
related to Biosynthesis · 12
Prostacyclin → Although, COX, COX-2, EPA, H2, I2, PGH2, PGH3, PGI2, PGI3, The, This
related to Mechanism · 9
Prostacyclin → A2, As, Gs, It, PGI2, PKA, The, This, TXA2
related to Medical uses · 6
Prostacyclin → III, In, It, IV PAH, PAH, Prostacyclins
related to Function · 5
Prostacyclin → Both, It, Prostacyclin's, These, TXA2
related to Artificial synthesis · 3
Prostacyclin → After, Because, F2α
related to Degradation · 3
Prostacyclin → Even, F1α, PGF1
related to Pharmacology · 3
Prostacyclin → PPH, Raynaud's, Synthetic
KEGG · 2
Prostacyclin → as salt: D01337, D00106
Legal status · 2
Prostacyclin → AU: S4 (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

platelet pgi2 also epoprostenol used thromboxane prostaglandin drug endothelial prostaglandins eicosanoid vasodilator activation cells camp txa2 team synthesis acid derived

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Prostacyclin3D model (JSmol)Interactive image1.00infobox
ProstacyclinAHFS/Drugs.comMonograph1.00infobox
ProstacyclinATC codeB01AC09 (WHO)1.00infobox
ProstacyclinCAS Number35121-78-9 Y1.00infobox
ProstacyclinChEMBLChEMBL1139 N1.00infobox
ProstacyclinChemSpider102770 N1.00infobox
ProstacyclinCompTox Dashboard (EPA)DTXSID50229881.00infobox
ProstacyclinDrugBankDB01240 N1.00infobox
ProstacyclinElimination half-life42 seconds1.00infobox
ProstacyclinFormulaC20H32O51.00infobox
ProstacyclinIUPHAR/BPS19151.00infobox
ProstacyclinKEGGD001061.00infobox
ProstacyclinKEGGas salt: D013371.00infobox
ProstacyclinLegal statusAU: S4 (Prescription only)1.00infobox
ProstacyclinLegal statusUS: ℞-only1.00infobox
ProstacyclinLicense dataUS DailyMed: Epoprostenol_sodium1.00infobox
ProstacyclinMolar mass352.471 g·mol−11.00infobox
ProstacyclinPregnancy categoryAU: B11.00infobox
ProstacyclinPubChem CID52824111.00infobox
ProstacyclinTrade namesFlolan, others1.00infobox
ProstacyclinUNIIDCR9Z582X01.00infobox

Related concept clusters Concept neighborhoods

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