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Prostaglandin E2

Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. In babies it is used in those with congenital heart defects…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G02AD02 (WHO)
CAS Number
363-24-6 Y
ChEBI
CHEBI:15551 N
ChEMBL
ChEMBL548 N

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Overview

Physiological effects

Medical uses

Mechanism of action

Contraindications

Pharmacokinetics

History

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Map overview Semantic statistics

Prostaglandin E2

Nodes82
Edges81
Triples140
Avg. degree1.98
Density0.02439
Components1

How this topic connects Entity context

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Prostaglandin E2

Top relations

has effect · 29
Prostaglandin E2 → Activation, Additionally, Administration, As, C-section, Ca2, Care, Conversely, COX-2, COX-2-derived, COX-2-derived PGE2, E2, EP, EP1, EP2, EP3, EP4, Fever, GFR, In
related to history · 16
Prostaglandin E2 → American, British, Corey, E2, Essential Medicines, Euler, FDA, Goldblatt, Prostaglandins, Sune Bergström, Swedish, The, This, Ulf, United States, World Health Organization's List
related to Mechanism of action · 15
Prostaglandin E2 → ADH-mediated, As, EP1, EP2, EP3, EP4, GPCRs, Henle, In, Loop, Na, NSAIDs, PGE2, TAL, Thick Ascending Limb
related to Toxicity · 12
Prostaglandin E2 → C-section, Cervidil, E2, If, Institute, PGE2, Prostin E2, Safe Medication Practices, The, There, This, When
related to Immunity · 10
Prostaglandin E2 → As, E2, EP2, In, PGE2, T-cell, T-lymphocyte, T-lymphocytes, TH1, When
related to Cervical ripening · 8
Prostaglandin E2 → Cervidil, In, PGE2, Pharmacological, Prepidil, Results, The, There
related to Administration · 7
Prostaglandin E2 → Cervidil, For, In, Once, PGE2, The, UK
related to Contraindications · 5
Prostaglandin E2 → Caution, Contraindications, Dinoprostone, PGE2, The
related to Pharmacokinetics · 4
Prostaglandin E2 → E2, NAD, PGE2, The
Legal status · 3
Prostaglandin E2 → EU: Rx-only, UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

pge2 prostaglandin e2 also used dinoprostone prostaglandins blood effects receptors use within babies vaginal smooth administration labor uterine inflammation muscle

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Prostaglandin E23D model (JSmol)Interactive image1.00infobox
Prostaglandin E2AHFS/Drugs.comMonograph1.00infobox
Prostaglandin E2ATC codeG02AD02 (WHO)1.00infobox
Prostaglandin E2CAS Number363-24-6 Y1.00infobox
Prostaglandin E2ChEBICHEBI:15551 N1.00infobox
Prostaglandin E2ChEMBLChEMBL548 N1.00infobox
Prostaglandin E2ChemSpider4444059 N1.00infobox
Prostaglandin E2CompTox Dashboard (EPA)DTXSID40229471.00infobox
Prostaglandin E2DrugBankDB00917 N1.00infobox
Prostaglandin E2ECHA InfoCard100.006.0521.00infobox
Prostaglandin E2FormulaC20H32O51.00infobox
Prostaglandin E2IUPHAR/BPS18831.00infobox
Prostaglandin E2KEGGD000791.00infobox
Prostaglandin E2Legal statusUK: POM (Prescription only)1.00infobox
Prostaglandin E2Legal statusUS: ℞-only1.00infobox
Prostaglandin E2Legal statusEU: Rx-only1.00infobox
Prostaglandin E2License dataEU EMA: by INN1.00infobox
Prostaglandin E2License dataUS DailyMed: Dinoprostone1.00infobox
Prostaglandin E2MedlinePlusa6825121.00infobox
Prostaglandin E2Molar mass352.471 g·mol−11.00infobox
Prostaglandin E2Other namesPGE2, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid1.00infobox
Prostaglandin E2Pregnancy categoryAU: C1.00infobox
Prostaglandin E2PubChem CID52803601.00infobox
Prostaglandin E2Routes of administrationIntravaginal, IV1.00infobox
Prostaglandin E2Trade namesProstin E2, Cervidil, Propess, others1.00infobox
Prostaglandin E2UNIIK7Q1JQR04M1.00infobox

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