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Hydroxyprogesterone caproate: History, Community, Culture & Applications

Hydroxyprogesterone caproate, sold under the brand name Delalutin among others, is a medication used to reduce the risk of preterm birth in women pregnant with one baby who have a history of spontaneous preterm birth. In March 2023, the manufacturer, Covis Pharma, agreed to withdraw the drug from the US market. The approval of this drug substance was…

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Hydroxyprogesterone caproate topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Hydroxyprogesterone caproate.

Related topics
241
Source areas
11
Connected nodes
253
Extracted relationships
141
Related term clusters
46
Bridge connections
253

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 162 topics
Medical uses · 26 topics
Chemistry · 13 topics
Side effects · 12 topics
Contraindications · 10 topics
History · 6 topics
Society and culture · 6 topics
Overdose · 2 topics
Research · 2 topics
Interactions · 1 topics
Veterinary uses · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
G03DA03 (WHO) G03FA02 (WHO)
Bioavailability
Oral: Very low (~3% in rats) Intramuscular: 100% (in rats)
CAS Number
630-56-8 Y
ChEBI
CHEBI:5812
ChEMBL
ChEMBL1200848

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Chemistry

History

Society and culture

Research

Veterinary uses

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Hydroxyprogesterone caproate connects Entity context

The extracted context around Hydroxyprogesterone caproate shows recurring relationship patterns in the source. For example, Hydroxyprogesterone caproate → Based, Drug Administration, FDA, Furthermore, Guidelines, Health, Hydroxyprogesterone, III, IM, Level, Maternal Fetal Medicine Clinic, May, National Institutes, NIH, One, Society, Three, US Food Another extracted example is Hydroxyprogesterone caproate → Along, Delalutin, Due, FDA, FDA Accelerated Approval Programs, February, Japan, Karl Junkmann, KV Pharmaceutical, Makena, NIH-sponsored, PROLONG, Renewed, Schering AG, Squibb, The FDA, United States. Use these groups to spot repeated connection types before inspecting the individual relationships.

Hydroxyprogesterone caproate

Top relations

related to Preterm birth · 18
Hydroxyprogesterone caproate → Based, Drug Administration, FDA, Furthermore, Guidelines, Health, Hydroxyprogesterone, III, IM, Level, Maternal Fetal Medicine Clinic, May, National Institutes, NIH, One, Society, Three, US Food
related to history · 17
Hydroxyprogesterone caproate → Along, Delalutin, Due, FDA, FDA Accelerated Approval Programs, February, Japan, Karl Junkmann, KV Pharmaceutical, Makena, NIH-sponsored, PROLONG, Renewed, Schering AG, Squibb, The FDA, United States
related to Availability · 14
Hydroxyprogesterone caproate → Asia, Australia, Canada, Central, China, Europe, Hydroxyprogesterone, Japan, Mexico, New Zealand, South Africa, South America, United Kingdom, United States
related to Available forms · 9
Hydroxyprogesterone caproate → Chinese Injectable No, EP Hormone Depot, Gravibinon, Hydroxyprogesterone, Japan, Makena, OHPC, Primosiston, Proluton
related to Economics · 7
Hydroxyprogesterone caproate → FDA, Hydroxyprogesterone, KV Pharmaceutical, Makena, The FDA, United States, US
related to Names · 7
Hydroxyprogesterone caproate → BANMTooltip British Approved Name, Hydroxyprogesterone, INNTooltip International Nonproprietary Name, JANTooltip Japanese Accepted Name, Name, OHPC, USANTooltip United States Adopted
has effect · 4
Hydroxyprogesterone caproate → Hydroxyprogesterone, Injection, Numerically, Side
is a · 3
Hydroxyprogesterone caproate → much more potent progestogen than 17α-hydroxyprogesterone, progestin, progestin medication which was used to prevent preterm birth in pregnant women with a history of the condition and to treat gynecological disorders
related to Chemistry · 3
Hydroxyprogesterone caproate → Analogues, C17α, Hydroxyprogesterone
related to Interactions · 3
Hydroxyprogesterone caproate → Drug, Hydroxyprogesterone, P450

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

caproate hydroxyprogesterone progesterone intramuscular women injection mg found used birth medication 17α-hydroxyprogesterone study also brand pregnant effects preterm activity name

Hydroxyprogesterone caproate relationships Subject–Predicate–Object triples

TTTA extracted 141 structured relationships around Hydroxyprogesterone caproate. Examples in this analysis include Hydroxyprogesterone caproate → 3D model (JSmol) → Interactive image and Hydroxyprogesterone caproate → ATC code → G03DA03 (WHO) G03FA02 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Hydroxyprogesterone caproate3D model (JSmol)Interactive image1.00infobox
Hydroxyprogesterone caproateATC codeG03DA03 (WHO) G03FA02 (WHO)1.00infobox
Hydroxyprogesterone caproateBioavailabilityOral: Very low (~3% in rats) Intramuscular: 100% (in rats)1.00infobox
Hydroxyprogesterone caproateCAS Number630-56-8 Y1.00infobox
Hydroxyprogesterone caproateChEBICHEBI:58121.00infobox
Hydroxyprogesterone caproateChEMBLChEMBL12008481.00infobox
Hydroxyprogesterone caproateChemSpider148552 Y1.00infobox
Hydroxyprogesterone caproateCompTox Dashboard (EPA)DTXSID60439151.00infobox
Hydroxyprogesterone caproateDrug classProgestogen; Progestin; Progestogen ester; Antigonadotropin1.00infobox
Hydroxyprogesterone caproateDrugBankDB06789 Y1.00infobox
Hydroxyprogesterone caproateECHA InfoCard100.010.1271.00infobox
Hydroxyprogesterone caproateElimination half-lifeNon-pregnant: 7.8 days Singlet: 16–17 days Twins: 10 days1.00infobox
Hydroxyprogesterone caproateExcretionFeces: 50% Urine: 30%1.00infobox
Hydroxyprogesterone caproateFormulaC27H40O41.00infobox
Hydroxyprogesterone caproateKEGGD009491.00infobox
Hydroxyprogesterone caproateLegal statusUS: withdrawn1.00infobox
Hydroxyprogesterone caproateMetabolismReduction and hydroxylation (via CYP3A4, CYP3A5, CYP3A7) and conjugation (glucuronidation, sulfation, acetylation)1.00infobox
Hydroxyprogesterone caproateMolar mass428.613 g·mol−11.00infobox
Hydroxyprogesterone caproateOther namesOHPC; Hydroxyprogesterone capronate; Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate; 17α-OHPC; 17-Hydroxyprogesterone caproate; 17-OHPC; 17-HPC; 17α-HPC; HPC; L…1.00infobox
Hydroxyprogesterone caproateProtein bindingExtensive (to albumin, not to CBGTooltip corticosteroid-binding globulin or (likely) SHBGTooltip sex hormone-binding globulin)1.00infobox
Hydroxyprogesterone caproatePubChem CID1698701.00infobox
Hydroxyprogesterone caproateRoutes of administrationIntramuscular injection, subcutaneous autoinjection1.00infobox
Hydroxyprogesterone caproateTrade namesDelalutin, Proluton, Makena, others1.00infobox
Hydroxyprogesterone caproateUNII276F2O42F51.00infobox
Hydroxyprogesterone caproateis aprogestin medication which was used to prevent preterm birth in pregnant women with a history of the condition and to treat gynecological disorders0.90text
Hydroxyprogesterone caproateis aprogestin0.90text
Hydroxyprogesterone caproateis amuch more potent progestogen than 17α-hydroxyprogesterone0.90text

Related concept clusters Related term clusters

The concept neighborhoods around Hydroxyprogesterone caproate bring nearby vocabulary together. In this analysis, examples include Hydroxyprogesterone, Injection and Intramuscular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Hydroxyprogesterone caproate
    • Hydroxyprogesterone
    • Injection
    • Intramuscular
    • Women
    • Mg
    • Progesterone
    • Found
    • Used
    • Study
    • 17α-hydroxyprogesterone
    • Effects
    • Pregnant
  • injectable birth control
    • Preterm
    • Risk
    • Marketed
    • Medication
    • Women
    • Name
    • Study
    • Pregnant
    • Drug
    • Makena
    • Fda
    • Brand
  • premature birth
    • Preterm
    • Risk
    • Medication
    • Women
    • Name
    • Study
    • Pregnant
    • Drug
    • Makena
    • Fda
    • Brand
    • Used
  • hydroxyprogesterone caproate
    • Hydroxyprogesterone
    • Injection
    • Intramuscular
    • Women
    • Mg
    • Found
    • Progesterone
    • Used
    • 17α-hydroxyprogesterone
    • Study
    • Effects
    • Pregnant
  • food and drug administration
    • Fda
    • Makena
    • Risk
    • Medication
    • Effects
    • Women
    • Pregnancy
    • Progestogen
    • Days
    • May
    • States
    • United
  • preterm delivery
    • Risk
    • Pregnant
    • Women
    • Used
    • Pregnancy
    • Progestogen
    • Study
    • Makena
    • May
    • Use
    • Progesterone
    • Activity
  • intramuscular injection
    • Intramuscular
    • Mg
    • Women
    • Found
    • Levels
    • Days
    • Effect
    • Study
    • Pregnancy
    • Use
    • Cancer
    • Makena
  • side effects
    • Pregnancy
    • Use
    • Activity
    • Progesterone
    • Makena
    • May
    • Hydroxyprogesterone
    • Preterm
    • Risk
    • Injection
    • Found
    • Women

Connections between topic areas Semantic bridges

For Hydroxyprogesterone caproate, one of the stronger structural bridges in this analysis connects Hydroxyprogesterone caproate with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Hydroxyprogesterone caproate — Overview · splits 90 ⟂ 164
Hydroxyprogesterone caproate — Medical uses · splits 227 ⟂ 27
Hydroxyprogesterone caproate — Chemistry · splits 240 ⟂ 14
Hydroxyprogesterone caproate — Side effects · splits 241 ⟂ 13
Hydroxyprogesterone caproate — Contraindications · splits 243 ⟂ 11
Hydroxyprogesterone caproate — History · splits 247 ⟂ 7
Hydroxyprogesterone caproate — Society and culture · splits 247 ⟂ 7
Hydroxyprogesterone caproate — Overdose · splits 251 ⟂ 3
Hydroxyprogesterone caproate — Research · splits 251 ⟂ 3

Map overview Semantic statistics

Hydroxyprogesterone caproate

Nodes254
Edges253
Triples141
Avg. degree1.99
Density0.007874
Components1

Source & methodology

TTTA analyzes the structure around Hydroxyprogesterone caproate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Hydroxyprogesterone caproate · EN edition · Analysis: TopicsToTalkAbout

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