Major prion protein

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Major prion protein. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Structure

Amino acid sequences Α-helices Antiparallel Β-sheet NH2-terminal

50 related topics

Diseases caused by PrP misfolding

Prion diseases Glutamic acid Lysine Codon Proline

38 related topics

Function

Transgenic Purkinje cells Cerebellum Doppel Circadian rhythm

17 related topics

Overview

Gene Cluster of differentiation Protein Nervous system Isoforms

36 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…
Band: 20p13 · 2 F2|2 64.07 cM
Bgee: Brodmann area 23 · Region I of hippocampus proper · retinal pigment epithelium · orbitofrontal cortex · endothelial cell
BioGPS: More reference expression data
Chr.: Chromosome 20 (human) · Chromosome 2 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Gene

Chromosome 20 Chromosome 20 (human)
Base pair

Interactions

Interaction Protein-protein interaction
Cochaperone
Hop Hop (protein)
Hsp70
Hsp90

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes155

Edges154

Triples149

Avg. degree1.99

Density0.012903

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Major prion protein

Top relations

Gene ontology · 86

Major prion protein → activation of protein kinase activity, amyloid-beta binding, anchored component of external side of plasma membrane, anchored component of membrane, ATP-dependent protein binding, calcium-mediated signaling using intracellular calcium source, cell cycle, cell surface, cellular copper ion homeostasis, cellular response to amyloid-beta, cellular response to copper ion, chaperone binding, copper ion binding, cupric ion binding, cuprous ion binding, cytoplasm, cytosol, dendrite, dendritic spine maintenance, endoplasmic reticulum

Bgee · 19

Major prion protein → amygdala, anterior amygdaloid area, Brodmann area 23, CA3 field, cingulate gyrus, decidua, endothelial cell, entorhinal cortex, Epithelium of choroid plexus, nucleus of stria terminalis, orbitofrontal cortex, pars compacta, perirhinal cortex, pons, Region I of hippocampus proper, retinal pigment epithelium, spinal ganglia, subiculum, trigeminal ganglion

RNA expression pattern · 19

Band · 2

Major prion protein → 2 F2|2 64.07 cM, 20p13

Chr. · 2

Major prion protein → Chromosome 2 (mouse), Chromosome 20 (human)

End · 2

Major prion protein → 131,780,349 bp, 4,701,590 bp

Aliases · 1

Major prion protein → PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein

Available structures · 1

Major prion protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…

BioGPS · 1

Major prion protein → More reference expression data

Databases · 1

Major prion protein → NCBI: entry; OMA: entry

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

prp prnp protein human prpc prpsc gene prion mice citation needed scrapie disease diseases copper function ad cell memory polymorphisms

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Major prion protein	Aliases	PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein	1.00	infobox
Major prion protein	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1,…	1.00	infobox
Major prion protein	Band	20p13	1.00	infobox
Major prion protein	Band	2 F2\|2 64.07 cM	1.00	infobox
Major prion protein	Bgee	Brodmann area 23	1.00	infobox
Major prion protein	Bgee	Region I of hippocampus proper	1.00	infobox
Major prion protein	Bgee	retinal pigment epithelium	1.00	infobox
Major prion protein	Bgee	orbitofrontal cortex	1.00	infobox
Major prion protein	Bgee	endothelial cell	1.00	infobox
Major prion protein	Bgee	spinal ganglia	1.00	infobox
Major prion protein	Bgee	trigeminal ganglion	1.00	infobox
Major prion protein	Bgee	pons	1.00	infobox
Major prion protein	Bgee	Epithelium of choroid plexus	1.00	infobox
Major prion protein	Bgee	pars compacta	1.00	infobox
Major prion protein	Bgee	nucleus of stria terminalis	1.00	infobox
Major prion protein	Bgee	CA3 field	1.00	infobox
Major prion protein	Bgee	entorhinal cortex	1.00	infobox
Major prion protein	Bgee	perirhinal cortex	1.00	infobox
Major prion protein	Bgee	amygdala	1.00	infobox
Major prion protein	Bgee	decidua	1.00	infobox
Major prion protein	Bgee	cingulate gyrus	1.00	infobox
Major prion protein	Bgee	subiculum	1.00	infobox
Major prion protein	Bgee	anterior amygdaloid area	1.00	infobox
Major prion protein	BioGPS	More reference expression data	1.00	infobox
Major prion protein	Chr.	Chromosome 20 (human)	1.00	infobox
Major prion protein	Chr.	Chromosome 2 (mouse)	1.00	infobox
Major prion protein	Databases	NCBI: entry; OMA: entry	1.00	infobox
Major prion protein	End	4,701,590 bp	1.00	infobox
Major prion protein	End	131,780,349 bp	1.00	infobox
Major prion protein	Ensembl	ENSG00000171867	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3