Fibroblast growth factor 21

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Fibroblast growth factor 21. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Regulation

Glycerol-3-phosphate Carbohydrate-responsive element-binding protein Glycerol kinase Glycerol-3-phosphate dehydrogenase Brown adipose tissue

15 related topics

Function

Glucose Adipocytes Insulin Phosphorylation FRS2

13 related topics

Overview

Protein Gene Fibroblast growth factor Agonist FGF21 receptor

19 related topics

Animal studies

PGC-1α Gluconeogenesis Ketogenesis ERK1/2 PPAR-gamma

8 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: FGF21, fibroblast growth factor 21
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E
Band: 19q13.33 · 7|7 B3
Bgee: right lobe of liver · pancreatic ductal cell · muscle of thigh · female breast · mammary gland
BioGPS: More reference expression data
Chr.: Chromosome 19 (human) · Chromosome 7 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Fibroblast growth factor
Agonist Receptor agonist
FGF21 receptor FGF21 receptor?action=edit&redlink=1
FGF receptor FGFR
Β-Klotho
Embryonic development Embryogenesis
Morphogenesis
Hepatokine Proteins produced and secreted by the liver
Hormone
Liver
Simple sugar
Hypothalamus
Dopamine
Neurotransmission
Nucleus accumbens
Single-nucleotide polymorphism
Behavioral phenotype

Regulation

Glycerol-3-phosphate Glycerol 3-phosphate
Carbohydrate-responsive element-binding protein
Glycerol kinase
Glycerol-3-phosphate dehydrogenase
Brown adipose tissue
White adipose tissue
Pancreas
Peroxisome proliferator-activated receptor alpha
ATF4
NRF NRF1
Blood-brain barrier Blood–brain barrier
Central nervous system
Hindbrain
Carbohydrate
Ketogenic diet

Function

Clinical significance

Type 2 diabetes mellitus

Animal studies

PGC-1α PPARGC1A
Gluconeogenesis
Ketogenesis
ERK1/2 Extracellular signal-regulated kinases
PPAR-gamma Peroxisome proliferator-activated receptor gamma
Methionine
AMPK AMP-activated protein kinase
Histone 3

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes62

Edges61

Triples96

Avg. degree1.97

Density0.032258

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Fibroblast growth factor 21

Top relations

Gene ontology · 26

Fibroblast growth factor 21 → cell-cell signaling, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to low-density lipoprotein particle stimulus, endoplasmic reticulum unfolded protein response, endothelial cell apoptotic process, extracellular region, extracellular space, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, negative regulation of endothelial cell apoptotic process, negative regulation of neuron death, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of triglyceride catabolic process, protein binding

Bgee · 20

Fibroblast growth factor 21 → axial skeleton, blood, calvaria, cornea, embryo, female breast, gastrocnemius muscle, head, islet of Langerhans, lactiferous gland, left lobe of liver, liver, mammary gland, mouth, muscle of thigh, pancreatic ductal cell, pyloric antrum, right lobe of liver, spermatid, thymus

RNA expression pattern · 20

Band · 2

Fibroblast growth factor 21 → 19q13.33, 7|7 B3

Chr. · 2

Fibroblast growth factor 21 → Chromosome 19 (human), Chromosome 7 (mouse)

End · 2

Fibroblast growth factor 21 → 45,264,914 bp, 48,758,333 bp

Aliases · 1

Fibroblast growth factor 21 → FGF21, fibroblast growth factor 21

Available structures · 1

Fibroblast growth factor 21 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E

BioGPS · 1

Fibroblast growth factor 21 → More reference expression data

Databases · 1

Fibroblast growth factor 21 → NCBI: entry; OMA: entry

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fgf21 liver expression protein glucose levels gene growth fgf response factor receptor also mice induced including fibroblast bp regulation humans

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Fibroblast growth factor 21	Aliases	FGF21, fibroblast growth factor 21	1.00	infobox
Fibroblast growth factor 21	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E	1.00	infobox
Fibroblast growth factor 21	Band	19q13.33	1.00	infobox
Fibroblast growth factor 21	Band	7\|7 B3	1.00	infobox
Fibroblast growth factor 21	Bgee	right lobe of liver	1.00	infobox
Fibroblast growth factor 21	Bgee	pancreatic ductal cell	1.00	infobox
Fibroblast growth factor 21	Bgee	muscle of thigh	1.00	infobox
Fibroblast growth factor 21	Bgee	female breast	1.00	infobox
Fibroblast growth factor 21	Bgee	mammary gland	1.00	infobox
Fibroblast growth factor 21	Bgee	lactiferous gland	1.00	infobox
Fibroblast growth factor 21	Bgee	gastrocnemius muscle	1.00	infobox
Fibroblast growth factor 21	Bgee	head	1.00	infobox
Fibroblast growth factor 21	Bgee	mouth	1.00	infobox
Fibroblast growth factor 21	Bgee	blood	1.00	infobox
Fibroblast growth factor 21	Bgee	pyloric antrum	1.00	infobox
Fibroblast growth factor 21	Bgee	embryo	1.00	infobox
Fibroblast growth factor 21	Bgee	thymus	1.00	infobox
Fibroblast growth factor 21	Bgee	calvaria	1.00	infobox
Fibroblast growth factor 21	Bgee	liver	1.00	infobox
Fibroblast growth factor 21	Bgee	islet of Langerhans	1.00	infobox
Fibroblast growth factor 21	Bgee	left lobe of liver	1.00	infobox
Fibroblast growth factor 21	Bgee	axial skeleton	1.00	infobox
Fibroblast growth factor 21	Bgee	cornea	1.00	infobox
Fibroblast growth factor 21	Bgee	spermatid	1.00	infobox
Fibroblast growth factor 21	BioGPS	More reference expression data	1.00	infobox
Fibroblast growth factor 21	Chr.	Chromosome 19 (human)	1.00	infobox
Fibroblast growth factor 21	Chr.	Chromosome 7 (mouse)	1.00	infobox
Fibroblast growth factor 21	Databases	NCBI: entry; OMA: entry	1.00	infobox
Fibroblast growth factor 21	End	48,758,333 bp	1.00	infobox
Fibroblast growth factor 21	End	45,264,914 bp	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3