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Rex1

Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells. In addition to being a marker for pluripotency, its regulation is also critical in maintaining a pluripotent state. As the cells begin to differentiate, Rex1 is severely and abruptly downregulated.

Embryo Development, P38 MAPK & Mesenchymal Stem Cells & Discovery

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Embryo Development

13 related topics

P38 MAPK & Mesenchymal Stem Cells

8 related topics

Discovery

7 related topics

Expression in Adult Tissues

4 related topics

Key facts & relationships

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Aliases
ZFP42, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein
Band
4q35.2 · 8 A4|8 23.89 cM
Bgee
buccal mucosa cell · gonad · amniotic fluid · sperm · testicle
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Discovery

Structure

P38 MAPK & Mesenchymal Stem Cells

Embryo Development

Expression in Adult Tissues

Rex1 Interactions with Other Transcription Factors

Advanced semantic analysis

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Map overview Semantic statistics

Rex1

Nodes48
Edges47
Triples126
Avg. degree1.96
Density0.041667
Components1

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Rex1

Top relations

Gene ontology · 19
Rex1 → cytoplasm, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, female gonad development, male gonad development, meiosis, metal ion binding, negative regulation of transcription by RNA polymerase II, nucleic acid binding, nucleus, PcG protein complex, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription regulator complex, transcription, DNA-templated
Bgee · 17
Rex1 → amniotic fluid, blastocyst, buccal mucosa cell, embryo, gonad, left testis, male human body, male reproductive system, morula, placenta, right testis, skin of thigh, sperm, spermatocyte, testicle, ureter, ventricular zone
RNA expression pattern · 17
Rex1 → amniotic fluid, blastocyst, buccal mucosa cell, embryo, gonad, left testis, male human body, male reproductive system, morula, placenta, right testis, skin of thigh, sperm, spermatocyte, testicle, ureter, ventricular zone
related to p38 MAPK & Mesenchymal Stem Cells · 11
Rex1 → Activated, Both, MAPK, MKK3, MSC, NOTCH, Proliferation, STAT3, The MSCs, Therefore, Thus
related to Discovery · 6
Rex1 → BA, F9, Hosler, ICM, RA, They
related to Tissue Derivation · 6
Rex1 → Also, As, During, ICM, Oct3/4, The
related to Gene Control · 5
Rex1 → DNA, Nespas, PEG3, Studies, YY1
related to Nanog · 5
Rex1 → C-terminus, Knockdown, Nanog, Rex-1, The Nanog
related to Oct3/4 · 5
Rex1 → At, However, In, Oct3/4, This
related to Expression in Adult Tissues · 4
Rex1 → It, The, Thus, Using

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Important terminology

cells expression found levels gene oct3 stem protein high bp chr human band transcription nanog peg3 differentiation chromosome p38 mapk

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Rex1AliasesZFP42, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein1.00infobox
Rex1Band4q35.21.00infobox
Rex1Band8 A4|8 23.89 cM1.00infobox
Rex1Bgeebuccal mucosa cell1.00infobox
Rex1Bgeegonad1.00infobox
Rex1Bgeeamniotic fluid1.00infobox
Rex1Bgeesperm1.00infobox
Rex1Bgeetesticle1.00infobox
Rex1Bgeeplacenta1.00infobox
Rex1Bgeeright testis1.00infobox
Rex1Bgeeleft testis1.00infobox
Rex1Bgeeskin of thigh1.00infobox
Rex1Bgeeventricular zone1.00infobox
Rex1Bgeeblastocyst1.00infobox
Rex1Bgeemorula1.00infobox
Rex1Bgeespermatocyte1.00infobox
Rex1Bgeeureter1.00infobox
Rex1Bgeeembryo1.00infobox
Rex1Bgeemale human body1.00infobox
Rex1Bgeemale reproductive system1.00infobox
Rex1BioGPSMore reference expression data1.00infobox
Rex1Chr.Chromosome 4 (human)1.00infobox
Rex1Chr.Chromosome 8 (mouse)1.00infobox
Rex1DatabasesNCBI: entry; OMA: entry1.00infobox
Rex1End188,005,046 bp1.00infobox
Rex1End43,760,017 bp1.00infobox
Rex1EnsemblENSG000001790591.00infobox
Rex1Entrez1326251.00infobox
Rex1External IDsOMIM: 614572; MGI: 99187; GeneCards: ZFP421.00infobox
Rex1Gene location (Human)Gene location (Human)Chr.Chromosome 4 (human)Band4q35.2Start187,995,771 bpEnd188,005,046 bp1.00infobox

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