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Rex1: Embryo Development, P38 MAPK & Mesenchymal Stem Cells & Discovery

Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells. In addition to being a marker for pluripotency, its regulation is also critical in maintaining a pluripotent state. As the cells begin to differentiate, Rex1 is severely and abruptly downregulated.

Language: English [EN]
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Rex1 topic overview

The analysis highlights Embryo Development, P38 MAPK & Mesenchymal Stem Cells and Discovery as prominent areas in the source structure around Rex1.

Related topics
40
Source areas
7
Connected nodes
47
Extracted relationships
115
Related term clusters
21
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Embryo Development · 13 topics
P38 MAPK & Mesenchymal Stem Cells · 8 topics
Discovery · 7 topics
Expression in Adult Tissues · 4 topics
Overview · 3 topics
Rex1 Interactions with Other Transcription Factors · 3 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ZFP42, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein
Band
4q35.2 · 8 A4|8 23.89 cM
Bgee
buccal mucosa cell · gonad · amniotic fluid · sperm · testicle
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Rex1
3Pluripotency · Embryonic stem cell · Cellular differentiation
7Murinae · Stem cells · Inner cell mass
4Testicles · In situ hybridization · Spermatocytes

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Structure

P38 MAPK & Mesenchymal Stem Cells

Embryo Development

Expression in Adult Tissues

Rex1 Interactions with Other Transcription Factors

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Rex1 connects Entity context

The extracted context around Rex1 shows recurring relationship patterns in the source. For example, Rex1 → cytoplasm, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, female gonad development, male gonad development, meiosis, metal ion binding, negative regulation of transcription by RNA polymerase II, nucleic acid binding, nucleus, PcG protein complex, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription regulator complex, transcription, DNA-templated Another extracted example is Rex1 → amniotic fluid, blastocyst, buccal mucosa cell, embryo, gonad, left testis, male human body, male reproductive system, morula, placenta, right testis, skin of thigh, sperm, spermatocyte, testicle, ureter, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Rex1

Top relations

Gene ontology · 19
Rex1 → cytoplasm, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, female gonad development, male gonad development, meiosis, metal ion binding, negative regulation of transcription by RNA polymerase II, nucleic acid binding, nucleus, PcG protein complex, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription regulator complex, transcription, DNA-templated
Bgee · 17
Rex1 → amniotic fluid, blastocyst, buccal mucosa cell, embryo, gonad, left testis, male human body, male reproductive system, morula, placenta, right testis, skin of thigh, sperm, spermatocyte, testicle, ureter, ventricular zone
RNA expression pattern · 17
Rex1 → amniotic fluid, blastocyst, buccal mucosa cell, embryo, gonad, left testis, male human body, male reproductive system, morula, placenta, right testis, skin of thigh, sperm, spermatocyte, testicle, ureter, ventricular zone
related to p38 MAPK & Mesenchymal Stem Cells · 10
Rex1 → Activated, MAPK, MKK3, MSC, NOTCH, Proliferation, STAT3, The MSCs, Therefore, Thus
related to Discovery · 5
Rex1 → BA, F9, Hosler, ICM, RA
related to Gene Control · 5
Rex1 → DNA, Nespas, PEG3, Studies, YY1
related to Nanog · 5
Rex1 → C-terminus, Knockdown, Nanog, Rex-1, The Nanog
related to Sox2 · 3
Rex1 → Cooperative, Nanog, Sox2
related to Tissue Derivation · 3
Rex1 → Also, ICM, Oct3/4
Band · 2
Rex1 → 4q35.2, 8 A4|8 23.89 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells expression found levels gene oct3 stem protein high bp chr human band transcription nanog peg3 differentiation chromosome p38 mapk

Rex1 relationships Subject–Predicate–Object triples

TTTA extracted 115 structured relationships around Rex1. Examples in this analysis include Rex1 → Aliases → ZFP42, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein and Rex1 → Band → 4q35.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Rex1AliasesZFP42, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein1.00infobox
Rex1Band4q35.21.00infobox
Rex1Band8 A4|8 23.89 cM1.00infobox
Rex1Bgeebuccal mucosa cell1.00infobox
Rex1Bgeegonad1.00infobox
Rex1Bgeeamniotic fluid1.00infobox
Rex1Bgeesperm1.00infobox
Rex1Bgeetesticle1.00infobox
Rex1Bgeeplacenta1.00infobox
Rex1Bgeeright testis1.00infobox
Rex1Bgeeleft testis1.00infobox
Rex1Bgeeskin of thigh1.00infobox
Rex1Bgeeventricular zone1.00infobox
Rex1Bgeeblastocyst1.00infobox
Rex1Bgeemorula1.00infobox
Rex1Bgeespermatocyte1.00infobox
Rex1Bgeeureter1.00infobox
Rex1Bgeeembryo1.00infobox
Rex1Bgeemale human body1.00infobox
Rex1Bgeemale reproductive system1.00infobox
Rex1BioGPSMore reference expression data1.00infobox
Rex1Chr.Chromosome 4 (human)1.00infobox
Rex1Chr.Chromosome 8 (mouse)1.00infobox
Rex1DatabasesNCBI: entry; OMA: entry1.00infobox
Rex1End188,005,046 bp1.00infobox
Rex1End43,760,017 bp1.00infobox
Rex1EnsemblENSG000001790591.00infobox
Rex1Entrez1326251.00infobox
Rex1External IDsOMIM: 614572; MGI: 99187; GeneCards: ZFP421.00infobox
Rex1Gene location (Human)Gene location (Human)Chr.Chromosome 4 (human)Band4q35.2Start187,995,771 bpEnd188,005,046 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Rex1 bring nearby vocabulary together. In this analysis, examples include Expression, Cells and Levels. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Rex1
    • Expression
    • Cells
    • Levels
    • High
    • Oct3
    • Protein
    • Differentiation
    • Transcription
    • Stem
    • Gene
    • Express
    • Expressed
  • rex1
    • Expression
    • Cells
    • Levels
    • High
    • Oct3
    • Protein
    • Differentiation
    • Transcription
    • Stem
    • Gene
    • Express
    • Expressed
  • embryonic stem cells
    • Stem
    • Rex1
    • Oct3
    • Found
    • Mouse
    • Zfp42
    • Expressed
    • Icm
    • Differentiate
    • Cell
    • Express
    • Transcription
  • stem cells
    • Stem
    • Rex1
    • Oct3
    • Found
    • Mouse
    • Zfp42
    • Expressed
    • Icm
    • Differentiate
    • Cell
    • Express
    • Transcription
  • gene
    • Location
    • Zfp42
    • Chromosome
    • Human
    • Bp
    • Chr
    • Protein
    • Mouse
    • Band
    • Peg3
    • Transcription
    • Stem
  • mesenchymal stem cells
    • Stem
    • Rex1
    • Oct3
    • Found
    • Mouse
    • Zfp42
    • Expressed
    • Icm
    • Differentiate
    • Cell
    • Express
    • Transcription
  • p38 mapk & mesenchymal stem cells
    • P38
    • Stem
    • Rex1
    • Oct3
    • Proliferation
    • Found
    • Expression
    • Mouse
    • Zfp42
    • Expressed
    • Icm
    • Differentiate
  • expression in adult tissues
    • Rex1
    • Levels
    • Mapk
    • P38
    • Transcription
    • Found
    • Protein
    • High
    • Factors
    • Inhibit
    • Proliferation
    • Thus

Connections between topic areas Semantic bridges

For Rex1, one of the stronger structural bridges in this analysis connects Rex1 with Embryo Development. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Rex1 — Embryo Development · splits 34 ⟂ 14
Rex1 — P38 MAPK & Mesenchymal Stem Cells · splits 39 ⟂ 9
Rex1 — Discovery · splits 40 ⟂ 8
Rex1 — Expression in Adult Tissues · splits 43 ⟂ 5
Rex1 — Overview · splits 44 ⟂ 4
Rex1 — Rex1 Interactions with Other Transcription Factors · splits 44 ⟂ 4
Rex1 — Structure · splits 45 ⟂ 3

Map overview Semantic statistics

Rex1

Nodes48
Edges47
Triples115
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around Rex1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Embryo Development, P38 MAPK & Mesenchymal Stem Cells & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Rex1 · EN edition · Analysis: TopicsToTalkAbout

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