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Sickle cell disease

Sickle cell disease (SCD), also simply called sickle cell, is a group of inherited hemoglobin-related blood disorders. Sickle cell disease is caused by an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to the red blood cells adopting an abnormal sickle-like shape under certain circumstances. With this shape…

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Causes
Genetic: inherited HBB gene mutation
Complications
Chronic pain, stroke, aseptic bone necrosis, gallstones, leg ulcers, priapism, pulmonary hypertension, vision problems, kidney problems
Deaths
34,000 p.a. (a contributory factor to a further 376,000 p.a.)
Diagnostic method
Blood test
Frequency
7.7 million (2021)
Other names
Sickle cell disorder; drepanocytosis (dated)

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Overview

Signs and symptoms

Genetics

Pathophysiology

Diagnosis

Genetic counselling

Treatment

Stem cell treatments

Prognosis

Epidemiology

United States

History

Society and culture

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Sickle cell disease

Nodes272
Edges271
Triples339
Avg. degree1.99
Density0.007353
Components1

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Sickle cell disease

Top relations

related to history · 42
Sickle cell disease → African, African-American, Beet, Case, Catholic, Chicago, Chicago Presbyterian Hospital, Childhood, December, Ernest, George's, Grenada, HbS, HbSC, He, Herrick, In, Irons, James, Lemuel Diggs
related to United States · 30
Sickle cell disease → African American, African Americans, African-American, African-Americans, Americans, An, Approximately, As, Black Panther Party, Daniel Cressy, Due, Elliott Vichinsky, Hispanic-American, In, In June, In September, Louisiana, Most, Over, Overall
related to Complications · 26
Sickle cell disease → About, An, Avascular, Cholelithiasis, Chronic, Daily, Diastolic, During, Even, Evidence, Haemophilus, If, In, Leg, Osteomyelitis, Patients, Priapism, Pulmonary, Salmonella, Sickle
related to Gene therapy · 24
Sickle cell disease → April, BCL11A, Both Casgevy, Casgevy, Children's National Hospital, CRISPR, DNA, England, Exa-cel, Gene, HbF, However, HSCs, In, Kendric Cromer, Lyfgenia, Medicine, National Health Service, New England Journal, NHS
related to Media and arts representation of sickle cell disease · 20
Sickle cell disease → American, British, Dr, Dream Runner, ER, Haitian-American, Hertz Nazaire, Justice, Lady, Lake, Michael, Noah Wyle, Obstruction, Popular, Representations, Robby, Robinavitch, Separation Anxiety, Supacell, The Pitt
related to France · 16
Sickle cell disease → African-Caribbean, Arabic, As, August, France, French, Greece, Indian, Mediterranean, North, North Africa, Saharan Africa, Sickle, Since, South Italy, Turkey
related to Africa · 15
Sickle cell disease → Africa, Baamba, Ghana, In, In Nigeria, In Uganda, Nigeria, North African, One, South Africa, The, Three-quarters, Uganda, West African, World Health Organization
related to Epidemiology · 14
Sickle cell disease → About, Europe, European, In, India, Middle East, Migration, Saharan, Saharan Africa, Sickle, Sub-Saharan Africa, The, The HbS, Where
related to United Kingdom · 14
Sickle cell disease → As, Casgevy, Donors, Due, England, In, In England, NHS, Other, The National Health Service, These, UK, United Kingdom, Voxelotor
has treatment · 10
Sickle cell disease → All, CRISPR, Haematopoietic, HbS, HSC, HSCs, More, Since, There, This

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Important terminology

cell sickle disease blood haemoglobin cells people gene red also pain carriers may abnormal symptoms malaria anaemia trait normal africa

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Sickle cell diseaseCausesGenetic: inherited HBB gene mutation1.00infobox
Sickle cell diseaseComplicationsChronic pain, stroke, aseptic bone necrosis, gallstones, leg ulcers, priapism, pulmonary hypertension, vision problems, kidney problems1.00infobox
Sickle cell diseaseDeaths34,000 p.a. (a contributory factor to a further 376,000 p.a.)1.00infobox
Sickle cell diseaseDiagnostic methodBlood test1.00infobox
Sickle cell diseaseFrequency7.7 million (2021)1.00infobox
Sickle cell diseaseOther namesSickle cell disorder; drepanocytosis (dated)1.00infobox
Sickle cell diseasePrognosisLife expectancy 40–60 years (developed world)1.00infobox
Sickle cell diseaseRisk factorsAncestry from sub-Saharan Africa, India, the Arab Gulf states or Sicily1.00infobox
Sickle cell diseaseSpecialtyHaematology, medical genetics1.00infobox
Sickle cell diseaseSymptomsAttacks of pain, anaemia, swelling in the hands and feet, bacterial infections, stroke1.00infobox
Sickle cell diseaseTreatmentVaccination, antibiotics, high fluid intake, folic acid supplementation, pain medication, blood transfusions1.00infobox
Sickle cell diseaseUsual onset5–6 months of age1.00infobox
Sickle cell diseaseis amost common genetic disorder among African Americans0.90text
Sickle cell diseaseis agenetic disease0.90text

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