Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Connexin: Function, Biosynthesis and internalization & Human connexins and clinical significance

Connexins (Cx) (TC# 1.A.24), or gap junction proteins, are structurally related transmembrane proteins that assemble to form vertebrate gap junctions. An entirely different family of proteins, the innexins, forms gap junctions in invertebrates. Each gap junction channel is composed of two hemichannels, or connexons, which consist of homo- or…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Connexin topic overview

The analysis highlights Function, Biosynthesis and internalization and Human connexins and clinical significance as prominent areas in the source structure around Connexin.

Related topics
42
Source areas
6
Connected nodes
48
Extracted relationships
84
Concept neighborhoods
17
Bridge connections
48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 18 topics
Overview · 8 topics
Biosynthesis and internalization · 6 topics
Human connexins and clinical significance · 5 topics
Structure · 3 topics
Nomenclature · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR013092 · PF00029
Available protein structures:
IPR013092 · PF00029
InterPro
IPR013092
OPM protein
2zw3
OPM superfamily
194
PDB
IPR013092 PF00029 (ECOD; PDBsum)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Nomenclature

Structure

Biosynthesis and internalization

Function

Human connexins and clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Connexin connects Entity context

The extracted context around Connexin shows recurring relationship patterns in the source. For example, Connexin → After, As, Cx26, EL-1, EL-2, ER, ERGIC, Golgi, However, It, The, UR-Golgi Another extracted example is Connexin → Connexins, Cx26, Cx43, Elsinore, Following, Gap Junction Conference, GJ, GJA, GJA1, GJB. Use these groups to spot repeated connection types before inspecting the individual relationships.

Connexin

Top relations

related to From the nucleus to the membrane · 12
Connexin → After, As, Cx26, EL-1, EL-2, ER, ERGIC, Golgi, However, It, The, UR-Golgi
related to Nomenclature · 10
Connexin → Connexins, Cx26, Cx43, Elsinore, Following, Gap Junction Conference, GJ, GJA, GJA1, GJB
related to Human connexins and clinical significance · 9
Connexin → Cx37, Cx40, Cx43, Cx47, For, Gap, Mutations, Pelizaeus-Merzbacher-like, While
related to Substrate specificity · 9
Connexin → ADP, AMP, ATP, Cx32, Cx43, Different, For, This, Thus
related to Function · 8
Connexin → By, Cell, Chordates, CNS, In, Innexin, Instead, Within
related to Structure · 8
Connexin → CL, Connexins, Cx26, EL-1, EL-2, GJB2, The, TMSs
related to Sources · 7
Connexin → All, As, Creative Commons Attribution-ShareAlike, Family, GFDL, The Gap Junction-forming Connexin, Unported License
related to External links · 6
Connexin → Media, Medicine Medical Subject Headings, MeSH, National Library, Wikimedia CommonsConnexins, Wiktionary-logo-en-v2
AlphaFold · 2
Connexin → IPR013092, PF00029
Available protein structures: · 2
Connexin → IPR013092, PF00029

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

connexins gap junction proteins junctions cell hemichannels membrane transmembrane six channels channel two four er formed may different processes development

Connexin relationships Subject–Predicate–Object triples

TTTA extracted 84 structured relationships around Connexin. Examples in this analysis include Connexin → AlphaFold → IPR013092 and Connexin → AlphaFold → PF00029. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ConnexinAlphaFoldIPR0130921.00infobox
ConnexinAlphaFoldPF000291.00infobox
ConnexinAvailable protein structures:IPR0130921.00infobox
ConnexinAvailable protein structures:PF000291.00infobox
ConnexinInterProIPR0130921.00infobox
ConnexinOPM protein2zw31.00infobox
ConnexinOPM superfamily1941.00infobox
ConnexinPDBIPR013092 PF00029 (ECOD; PDBsum)1.00infobox
ConnexinPfamPF000291.00infobox
ConnexinPROSITEPDOC003411.00infobox
ConnexinSymbolConnexin1.00infobox
ConnexinTCDB1.A.241.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Connexin bring nearby vocabulary together. In this analysis, examples include Gap, Proteins and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Connexin
    • Gap
    • Proteins
    • Protein
    • Essential
    • Family
    • Coupling
    • Human
    • May
    • Six
    • Connexins
    • Hemichannels
    • Junctions
  • connexin
    • Gap
    • Proteins
    • Protein
    • Essential
    • Family
    • Coupling
    • Human
    • May
    • Six
    • Connexins
    • Hemichannels
    • Junctions
  • gap junction
    • Junction
    • Junctions
    • Proteins
    • Nomenclature
    • Human
    • Channel
    • Membrane
    • Connexin
    • Composed
    • Connexons
    • Cell
    • Hemichannels
  • gap junction protein
    • Junction
    • Junctions
    • Proteins
    • Nomenclature
    • Human
    • Channel
    • Membrane
    • Connexin
    • Composed
    • Connexons
    • Cell
    • Hemichannels
  • human connexins and clinical significance
    • Nomenclature
    • Junction
    • Gap
    • Two
    • Different
    • Er
    • Protein
    • May
    • Membrane
    • Formed
    • Cell
    • Hemichannels
  • proteins
    • Channels
    • Transmembrane
    • Innexins
    • Connexin
    • Junctions
    • Pannexins
    • Different
    • Membrane
    • Six
    • Hemichannels
    • Composed
    • Cytoskeleton
  • adherens junctions
    • Innexins
    • Microvasculature
    • Essential
    • Physiological
    • Proteins
    • Development
    • Different
    • Processes
    • Connexin
    • Family
    • Functional
    • Also
  • plasma membrane
    • Six
    • Proteins
    • Nomenclature
    • Er
    • Four
    • Human
    • Two
    • Transmembrane
    • Connexin

Connections between topic areas Semantic bridges

For Connexin, one of the stronger structural bridges in this analysis connects Connexin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Connexin — Function · splits 30 ⟂ 19
Connexin — Overview · splits 40 ⟂ 9
Connexin — Biosynthesis and internalization · splits 42 ⟂ 7
Connexin — Human connexins and clinical significance · splits 43 ⟂ 6
Connexin — Structure · splits 45 ⟂ 4
Connexin — Nomenclature · splits 46 ⟂ 3

Map overview Semantic statistics

Connexin

Nodes49
Edges48
Triples84
Avg. degree1.96
Density0.040816
Components1

Source & methodology

TTTA analyzes the structure around Connexin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Biosynthesis and internalization & Human connexins and clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Connexin · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.