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Connexin

Connexins (Cx) (TC# 1.A.24), or gap junction proteins, are structurally related transmembrane proteins that assemble to form vertebrate gap junctions. An entirely different family of proteins, the innexins, forms gap junctions in invertebrates. Each gap junction channel is composed of two hemichannels, or connexons, which consist of homo- or…

Function, Biosynthesis and internalization & Human connexins and clinical significance

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Function

VertebratesInnexinInvertebrateChordatesPannexins
18 related topics

Biosynthesis and internalization

MyometriumEROligomerizationERGICCadherins
6 related topics

Human connexins and clinical significance

IsoformsOculodentodigital dysplasiaPelizaeus-MerzbacherLymphedemaAtrial fibrillation
5 related topics

Structure

Transmembrane segmentsHuman genomeAmino acids
3 related topics

Key facts & relationships

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AlphaFold
IPR013092 · PF00029
Available protein structures:
IPR013092 · PF00029
InterPro
IPR013092
OPM protein
2zw3
OPM superfamily
194
PDB
IPR013092 PF00029 (ECOD; PDBsum)

Topics to explore

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Overview

Nomenclature

Structure

Biosynthesis and internalization

Function

Human connexins and clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Connexin

Nodes49
Edges48
Triples84
Avg. degree1.96
Density0.040816
Components1

How this topic connects Entity context

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Connexin

Top relations

related to From the nucleus to the membrane · 12
Connexin → After, As, Cx26, EL-1, EL-2, ER, ERGIC, Golgi, However, It, The, UR-Golgi
related to Nomenclature · 10
Connexin → Connexins, Cx26, Cx43, Elsinore, Following, Gap Junction Conference, GJ, GJA, GJA1, GJB
related to Human connexins and clinical significance · 9
Connexin → Cx37, Cx40, Cx43, Cx47, For, Gap, Mutations, Pelizaeus-Merzbacher-like, While
related to Substrate specificity · 9
Connexin → ADP, AMP, ATP, Cx32, Cx43, Different, For, This, Thus
related to Function · 8
Connexin → By, Cell, Chordates, CNS, In, Innexin, Instead, Within
related to Structure · 8
Connexin → CL, Connexins, Cx26, EL-1, EL-2, GJB2, The, TMSs
related to Sources · 7
Connexin → All, As, Creative Commons Attribution-ShareAlike, Family, GFDL, The Gap Junction-forming Connexin, Unported License
related to External links · 6
Connexin → Media, Medicine Medical Subject Headings, MeSH, National Library, Wikimedia CommonsConnexins, Wiktionary-logo-en-v2
AlphaFold · 2
Connexin → IPR013092, PF00029
Available protein structures: · 2
Connexin → IPR013092, PF00029

Important terminology Word statistics

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Important terminology

connexins gap junction proteins junctions cell hemichannels membrane transmembrane six channels channel two four er formed may different processes development

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ConnexinAlphaFoldIPR0130921.00infobox
ConnexinAlphaFoldPF000291.00infobox
ConnexinAvailable protein structures:IPR0130921.00infobox
ConnexinAvailable protein structures:PF000291.00infobox
ConnexinInterProIPR0130921.00infobox
ConnexinOPM protein2zw31.00infobox
ConnexinOPM superfamily1941.00infobox
ConnexinPDBIPR013092 PF00029 (ECOD; PDBsum)1.00infobox
ConnexinPfamPF000291.00infobox
ConnexinPROSITEPDOC003411.00infobox
ConnexinSymbolConnexin1.00infobox
ConnexinTCDB1.A.241.00infobox

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    Min side: 3
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